Preferential Regulation of Γ‐Secretase‐Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease [PDF]
Advanced Science, 2023 A hallmark of Alzheimer's disease (AD) is the senile plaque, which contains β‐amyloid peptides (Aβ). Ganglioside GM1 is the most common brain ganglioside. However, the mechanism of GM1 in modulating Aβ processing is rarely known.
Xiaotong Wang +2 more
exaly +3 more sources
Pathophysiology of Ganglioside GM1 in Ischemic Stroke: Ganglioside GM1: A Critical Review [PDF]
Cell Transplantation, 2019 Ganglioside GM1 is a member of the ganglioside family which has been used in many countries and is thought of as a promising alternative treatment for preventing several neurological diseases, including cerebral ischemic injury.
Wenchao Zhang +2 more
exaly +3 more sources
Effects of ganglioside GM1 and erythropoietin on spinal cord injury in mice: Functional and immunohistochemical assessments [PDF]
Clinics, 2022 Objectives: To evaluate the functional and immunohistochemical effects of ganglioside GM1 and erythropoietin following experimental spinal cord injury. Methods: Thirty-two male BALB/c mice were subjected to experimental spinal cord injury using the NYU ...
Alessandro Gonzalez Torelli +6 more
doaj +3 more sources
The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation [PDF]
Membranes, 2020 Ganglioside GM1 is the most common brain ganglioside enriched in plasma membrane regions known as lipid rafts or membrane microdomains. GM1 participates in many modulatory and communication functions associated with the development, differentiation, and ...
Vladimir Rudajev, Jiri Novotny
doaj +2 more sources
Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 gangliosidosis
Journal of Lipid Research, 2023 GM1 gangliosidosis is a neurodegenerative disorder caused by mutations in the GLB1 gene, which encodes lysosomal β-galactosidase. The enzyme deficiency blocks GM1 ganglioside catabolism, leading to accumulation of GM1 ganglioside and asialo-GM1 ...
Colleen Byrnes +2 more
exaly +3 more sources
Ganglioside GM1 Targets Astrocytes to Stimulate Cerebral Energy Metabolism [PDF]
Frontiers in Pharmacology, 2021 Gangliosides are major constituents of the plasma membrane and are known to promote a number of physiological actions in the brain, including synaptic plasticity and neuroprotection.
Charles Finsterwald +3 more
doaj +2 more sources
Sphingomyelinase‐Mediated Multitimescale Clustering of Ganglioside GM1 in Heterogeneous Lipid Membranes [PDF]
Advanced Science, 2021 Several signaling processes in the plasma membrane are intensified by ceramides that are formed by sphingomyelinase‐mediated hydrolysis of sphingomyelin.
Hyun‐Ro Lee, Siyoung Q. Choi
doaj +2 more sources
Cholesterol accelerates the binding of Alzheimer’s beta-amyloid peptide to ganglioside GM1 through a universal hydrogen-bond-dependent sterol tuning of glycolipid conformation. [PDF]
Frontiers in Physiology, 2013 Age-related alterations of membrane lipids in brain cell membranes together with high blood cholesterol are considered as major risk factors for Alzheimer’s disease. Yet the molecular mechanisms by which these factors increase Alzheimer’s risk are mostly
Jacques eFantini +2 more
doaj +2 more sources
Disease‐modifying effects of ganglioside GM1 in Huntington's disease models [PDF]
EMBO Molecular Medicine, 2017 Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive and psychiatric problems. Previous studies indicated that levels of brain gangliosides are lower than normal in HD models and that administration of ...
Melanie Alpaugh +12 more
doaj +2 more sources
Ganglioside GM1 and the Central Nervous System. [PDF]
Int J Mol Sci, 2023 Guo Z.
europepmc +3 more sources