Guillain-Barré Syndrome-related campylobacter jejuni in Bangladesh: ganglioside mimicry and cross-reactive antibodies [PDF]
, 2012 BACKGROUND: <br/> Campylobacter jejuni is the predominant antecedent infection in Guillain-Barré syndrome (GBS). Molecular mimicry and cross-reactive immune responses to C.
Endtz, H.P. +11 more
core +27 more sources
Turning the spotlight on the oligosaccharide chain of GM1 ganglioside. [PDF]
Glycoconj J, 2021 AbstractIt is well over a century that glycosphingolipids are matter of interest in different fields of research. The hydrophilic oligosaccharide and the lipid moiety, the ceramide, both or separately have been considered in different moments as the crucial portion of the molecule, responsible for the role played by the glycosphingolipids associated to
Chiricozzi E +7 more
europepmc +5 more sources
Endocytosis of cholera toxin in GERL-like structures of murine neuroblastoma cells pretreated with GM1 ganglioside. Cholera toxin internalization into Neuroblastoma GERL. [PDF]
Journal of Cell Biology, 1979 A Stieber, N K Gonatas
exaly +2 more sources
Titration of serum anti-ganglioside antibodies in patients with chronic medular injury previous to treatment with GM1 ganglioside [PDF]
Acta Ortopédica Brasileira, 2003 Anti-ganglioside serum titers were evaluated by ELISA in 150 patients with complete spinal cord lesion for 6 to 12 months (IgG monosialo GM1, IgM monosialo GM1, IgG asialo GM1, IgM asialo GM1, IgG disialo GD1b e IgM disialo GD1b) prior to treatment with ...
Tarcísio Eloy Pessoa Barros Filho +1 more
doaj +1 more source
Bovine lactoferrin decreases cholera-toxin-induced intestinal fluid accumulation in mice by ganglioside interaction. [PDF]
PLoS ONE, 2013 Secretory diarrhea caused by cholera toxin (CT) is initiated by binding of CT's B subunit (CTB) to GM1-ganglioside on the surface of intestinal cells. Lactoferrin, a breast milk glycoprotein, has shown protective effect against several enteropathogens ...
Fulton P Rivera +7 more
doaj +1 more source
Host factors determine anti-GM1 response following oral challenge of chickens with Guillain-Barré syndrome derived Campylobacter jejuni strain GB11. [PDF]
PLoS ONE, 2010 BackgroundAnti-ganglioside antibodies with a pathogenic potential are present in C. jejuni-associated Guillain-Barré syndrome (GBS) patients and are probably induced by molecular mimicry.
C Wim Ang +7 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2022 GM1-gangliosidosis is a progressive neurodegenerative glycosphingolipidosis resulting from a GLB1 gene mutation causing a deficiency of the lysosomal enzyme β-galactosidase, which leads to the abnormal accumulation of GM1 ganglioside in the central ...
Toshiki Tsunogai +8 more
doaj +1 more source
The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation
Membranes, 2020 Ganglioside GM1 is the most common brain ganglioside enriched in plasma membrane regions known as lipid rafts or membrane microdomains. GM1 participates in many modulatory and communication functions associated with the development, differentiation, and ...
Vladimir Rudajev, Jiri Novotny
doaj +1 more source
Gangliosides and the Treatment of Neurodegenerative Diseases: A Long Italian Tradition
Biomedicines, 2022 Gangliosides are glycosphingolipids which are particularly abundant in the plasma membrane of mammalian neurons. The knowledge of their presence in the human brain dates back to the end of 19th century, but their structure was determined much later, in ...
Maria Fazzari +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 α-Synuclein is a membrane-interacting protein involved in Parkinson’s disease. Here we have investigated the co-association of α-synuclein and lipids from ganglioside-containing model membranes.
Ricardo Gaspar +5 more
doaj +1 more source