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Gangliosides in Neuroblastomas
Neurochemical Pathology, 1988Neuroblastomas from children presenting with tumors at various ages and different primary sites (abdominal, adrenals, pelvic, and thoracic) were studied. Analysis of the ganglioside patterns of 53 tumors indicated that patients who were either disease positive 2 yr following surgery or dead of disease, had significantly (p less than 0.005) less GT1b ...
C L, Schengrund, S J, Shochat
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Gangliosides as Immunomodulators
2007Gangliosides are glycosphingolipids expressed at the outer leaflet of the plasmatic membrane of cells from vertebrate organisms. These molecules exert diverse biological functions including modulation of the immune system responses. Aberrant expression of gangliosides has been demonstrated on malignant cells. Besides expression on tumor cell membranes,
Miroslava, Potapenko +2 more
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Drugs, 1994
Gangliosides are normal constituent of mammalian vertebrate cell membranes and are particularly abundant in the central and peripheral nervous systems. The biological effects of exogenously administered gangliosides have been extensively investigated in vitro and in experimental animal models where they have neuronotrophic and neuritogenic properties ...
E. Nobile-Orazio, M. Carpo, G. Scarlato
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Gangliosides are normal constituent of mammalian vertebrate cell membranes and are particularly abundant in the central and peripheral nervous systems. The biological effects of exogenously administered gangliosides have been extensively investigated in vitro and in experimental animal models where they have neuronotrophic and neuritogenic properties ...
E. Nobile-Orazio, M. Carpo, G. Scarlato
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2018
Tumor-associated gangliosides play important roles in regulation of signal transduction induced by growth-factor receptors including EGFR, FGFR, HGF and PDGFR in a specific microdomain called glycosynapse in the cancer cell membranes, and in interaction with glycan recognition molecules involved in cell adhesion and immune regulation including ...
Reiji, Kannagi +4 more
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Tumor-associated gangliosides play important roles in regulation of signal transduction induced by growth-factor receptors including EGFR, FGFR, HGF and PDGFR in a specific microdomain called glycosynapse in the cancer cell membranes, and in interaction with glycan recognition molecules involved in cell adhesion and immune regulation including ...
Reiji, Kannagi +4 more
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New England Journal of Medicine, 1971
For almost 100 years Tay-Sachs disease was the only ganglioside storage disease known. A second inborn error of ganglioside metabolism, generalized gangliosidosis, was discovered in 1965.13,35 Three additional ganglioside storage diseases have recently been uncovered,4,3,52,66,74 bringing the total to five.36 Of these, three involve storage of ...
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For almost 100 years Tay-Sachs disease was the only ganglioside storage disease known. A second inborn error of ganglioside metabolism, generalized gangliosidosis, was discovered in 1965.13,35 Three additional ganglioside storage diseases have recently been uncovered,4,3,52,66,74 bringing the total to five.36 Of these, three involve storage of ...
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GANGLIOSIDES IN THE NERVOUS SYSTEM
Neurochemistry International, 1983Gangliosides, sialic acid-containing glycosphingolipids, are embedded in neural plasma membranes to provide cell surface recognition sites with negative charges. Exogenous ligands such as bacterial toxins, hormones, growth factors, antibodies, viruses, and interferons bind to specific gangliosides to induce sequential activations of cellular ...
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Gangliosides and Cell Surface Ganglioside Glycohydrolases in the Nervous System
2014Gangliosides are a large group of complex lipids found predominantly on the outer layer of the plasma membranes of cells, and they are particularly concentrated in nerve endings. Their half-life in the nervous system is short, and their membrane composition and content are strictly connected to their metabolism.
M. Aureli +7 more
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Gangliosides of the Nervous System.
Methods in molecular biology, 2018R. Ledeen, Gu-Sheng Wu
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Raft-based interactions of gangliosides with a GPI-anchored receptor.
Nature Chemical Biology, 2016N. Komura +16 more
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