Results 181 to 190 of about 5,135,710 (246)

A new ganoderic acid from Ganoderma lucidum mycelia

Journal of Asian Natural Products Research, 2010
A new ganoderic acid (GA), 7-O-ethyl ganoderic acid O (GA-O) (1), together with two known compounds, GA-T (2) and GA-Me (3), was isolated and purified from fermented mycelia of Ganoderma lucidum. The structure of the new triterpenoid was elucidated on the basis of the interpretation of extensive spectroscopic data (HR-MS, IR, UV, 1D and 2D NMR) as 3 ...
Jia-Le, Wang, Ying-Bo, Li, Ru-Ming, Liu, Jian-Jiang, Zhong   +3 more
openaire   +2 more sources

Ganoderic acid, lanostanoid triterpene: a key player in apoptosis

Investigational New Drugs, 2017
Cancer is a multifactorial disease, causing behavioral and metabolic alterations, leading to uncontrolled cell proliferation with collateral weakening of immune system. Crucial balance between cell proliferation and cell death determines the fate of a cell, which might progress towards survival or apoptosis.
Balraj Singh, Gill, , Navgeet, Richa, Mehra, Vicky, Kumar, Sanjeev, Kumar   +4 more
openaire   +2 more sources

Protective effect of Ganoderic acid A on adjuvant-induced arthritis

Immunology Letters, 2020
The purpose of the experiment was to explore the effect of Ganoderic acid A (GAA) on adjuvant-induced arthritis in rats. In this study, the rat model of collagen-induced rheumatoid arthritis (CIA) was established with type II collagen plus Freund's complete adjuvant. Arthritis index, joint pathology, toe swelling, hemorheology, synovial cell apoptosis,
Tao, Cao, Chuanfeng, Tang, Lezhen, Xue, Mingzhu, Cui, Dan, Wang   +4 more
openaire   +2 more sources

Ganoderic acid A alleviate psoriasis by inhibiting GSDMD-mediated pyroptosis.

Tissue and Cell
Chenggen Xiao, Junchen Chen, Xingchen Zhou, Hong Liu   +3 more
semanticscholar   +2 more sources

Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum

Biotechnology Letters, 2006
Ganoderic acid, from Ganoderma lucidum, at 8 microg/ml inhibited replication of hepatitis B virus (HBV) in HepG2215 cells over 8 days. Production of HBV surface antigen and HBV e antigen were 20 and 44% of controls without ganoderic acid. Male KM mice were significantly protected from liver injury, induced with carbon tetrachloride, by treatment with ...
Yan-Qun, Li, Shun-Fa, Wang
openaire   +2 more sources

ChemInform Abstract: Ganoderic Acid DM: Antiandrogenic Osteoclastogenesis Inhibitor.

ChemInform, 2009
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Jie Liu, Jun Shiono, Kuniyoshi Shimizu, Akiko Kukita, Toshio Kukita, Ryuichiro Kondo   +5 more
openaire   +1 more source

Improving Lung Injury in Sepsis‐Related Systemic Inflammatory Response Syndrome Through Regulation of the TLR4/NF‐κB Pathway and Macrophage Polarization by Ganoderic Acid A

Chemical Biology and Drug Design
This study aimed to investigate the effects and mechanisms of Ganoderic acid A (GAA) on lung injury associated with systemic inflammatory response syndrome (SIRS). Forty Sprague Dawley rats were divided into four groups: Control group, GAA group (GAA, 40 
Mingjie Zhu, Jianru Shang, Shang Che
semanticscholar   +1 more source

Ganoderic acid A against cyclophosphamide‐induced hepatic toxicity in mice

Journal of Biochemical and Molecular Toxicology, 2018
AbstractThis study clarified the protective effect of ganoderic acid A (GAA) on cyclophosphamide (CP)‐induced hepatotoxicity in mice. Hepatic injury mice were induced by a single intraperitoneal injection of CP (200 mg/kg). The results showed that the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and liver of ...
Xu Lixin, Yan Lijun, Huang Songping
openaire   +2 more sources

Preparative isolation of ganoderic acid S, ganoderic acid T and ganoderol B from Ganoderma lucidum mycelia by high‐speed counter‐current chromatography

Biomedical Chromatography, 2018
AbstractGanoderic acid S, ganoderic acid T and ganoderal B are the main bioactive triterpenes of Ganoderma lucidum. In this study, mycelia of G. lucidum were obtained by two‐stage fermentation and then extracted by ethanol and petroleum ether sequentially to obtain crude triterpenes. The crude sample was further purified by recycling high‐speed counter‐
Na Feng, Yutian Wei, Jie Feng, Qingjiu Tang, Zhong Zhang, Jingsong Zhang, Wei Han   +6 more
openaire   +2 more sources

In Silico Investigation of Ganoderic Acid A Targeting Amyloid-Beta and Tau Protein Aggregation in Alzheimer's Disease.

International Journal of Medicinal Mushrooms
Alzheimer's disease (AD) represents a significant challenge in neurodegenerative disorders, characterized by the accumulation of amyloid-beta (Aβ) plaques and tau protein tangles in the brain. Current treatments provide symptomatic relief but do not halt
Abuzer Ali, Ankit Ganeshpurkar, Aditya Ganeshpurkar, Nazneen Dubey   +3 more
semanticscholar   +1 more source