Results 161 to 170 of about 10,080 (200)
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Protective effect of Ganoderic acid A on adjuvant-induced arthritis
Immunology Letters, 2020The purpose of the experiment was to explore the effect of Ganoderic acid A (GAA) on adjuvant-induced arthritis in rats. In this study, the rat model of collagen-induced rheumatoid arthritis (CIA) was established with type II collagen plus Freund's complete adjuvant. Arthritis index, joint pathology, toe swelling, hemorheology, synovial cell apoptosis,
Tao, Cao +4 more
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Biotechnological production and application of ganoderic acids
Applied Microbiology and Biotechnology, 2010Ganoderic acids (GAs), a kind of highly oxygenated lanostane-type triterpenoids, are important bioactive constituents of the famous medicinal mushroom Ganoderma lucidum. They have received wide attention in recent years due to extraordinarily pharmacological functions. Submerged fermentation of G.
Jun-Wei, Xu +2 more
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Ganoderic acid, lanostanoid triterpene: a key player in apoptosis
Investigational New Drugs, 2017Cancer is a multifactorial disease, causing behavioral and metabolic alterations, leading to uncontrolled cell proliferation with collateral weakening of immune system. Crucial balance between cell proliferation and cell death determines the fate of a cell, which might progress towards survival or apoptosis.
Balraj Singh, Gill +4 more
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Ganoderic acid B attenuates LPS-induced lung injury
International Immunopharmacology, 2020Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a serious respiratory disease, the mechanism is unclear. This paper revealed the mechanism of ganoderic acid B (BB) on lipopolysaccharide-induced pneumonia in mice. Pneumonia model was induced by LPS in mice and A549 cells. Lung dry/wet weight (W/D) and myeloperoxidase (MPO) activity
Jiang, Shi +7 more
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Ganoderic Acid and Lucidenic Acid (Triterpenoid)
2014Ganoderma species is known as a functional mushroom used in many Asian countries. Triterpenoids, ganoderic acids, and lucidenic acids have been isolated from Ganoderma species (Ganodermataceae family), such as Ganoderma lucidum. Triterpenoids have been investigated for their biological activities, including antibacterial, antiviral, antitumor ...
Chin-Lin, Hsu, Gow-Chin, Yen
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Current progress in the study on biosynthesis and regulation of ganoderic acids
Applied Microbiology and Biotechnology, 2010Ganoderic acids (GAs) isolated from Ganoderma lucidum, which have shown remarkable pharmacological activities and a variety of therapeutic effects on a number of human diseases, have provided an important resource for the development of new medicines.
Liang, Shi +3 more
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Ganoderic Acid A Inhibits Bleomycin-Induced Lung Fibrosis in Mice
Pharmacology, 2020<b><i>Background:</i></b> To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. <b><i>Methods:</i></b> ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0.
Gaoyan, Wen +4 more
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Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice
Food & Function, 2021Ganoderic acid, isolated from Ganoderma lucidum, significantly ameliorated 5-FU induced cognitive impairment via preventing mitochondrial impairment and enhancing neuronal survival and growth.
Abudumijiti Abulizi +12 more
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Antioxidant potential of ganoderic acid in Notch-1 protein in neuroblastoma
Molecular and Cellular Biochemistry, 2018Neuroblastoma is a childhood tumor arising from developing a sympathetic nervous system and causes around 10% of pediatric tumors. Despite advancement in the use of sophisticated techniques in molecular biology, neuroblastoma patient's survivability rate is very less.
Balraj Singh, Gill +2 more
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Mitochondrial pyruvate carrier influences ganoderic acid biosynthesis in Ganoderma lucidum
Applied Microbiology and Biotechnology, 2023Mitochondrial pyruvate carriers (MPCs), located in the inner membrane of mitochondria, are essential carriers for pyruvate to enter mitochondria. MPCs regulate a wide range of intracellular metabolic processes, such as glycolysis, the tricarboxylic acid cycle (TCA cycle), fatty acid metabolism, and amino acid metabolism.
Juhong Chen +8 more
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