Results 181 to 190 of about 10,669 (208)

Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth

Clinical and Translational Oncology, 2019
N-myc downstream-regulated gene 2 (NDRG2) is down-regulated in grade-III meningioma [anaplastic meningioma (AM)] and associated with clinically aggressive behavior. Current therapies in the treatment of high-grade meningioma are lacking with limited success.
A. Das, M. Alshareef, F. Henderson, J. L. Martinez Santos, W. A. Vandergrift, S. M. Lindhorst, A. K. Varma, L. Infinger, S. J. Patel, D. Cachia   +9 more
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Ganoderic acid A exerted antidepressant-like action through FXR modulated NLRP3 inflammasome and synaptic activity

Biochemical Pharmacology, 2021
Major depressive disorder (MDD) is a common, chronic, recurrent disease. The existing drugs are ineffective for approximately half of patients, so the development of antidepressant drugs with novel mechanisms is urgent. Cumulative evidence has shown neuro-inflammation plays a key role in the etiology of major depressive disorder.
Hongkun Bao, Haoran Li, Yue Jia, Yuhuan Xiao, Shaolei Luo, Dandan Zhang, Li Han, Lili Dai, Chunjie Xiao, Lei Feng, Yuan Feng, Yang Yang, Han Wang, Gang Wang, Jing Du   +14 more
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Ganoderic Acid A: A Potential Natural Neuroprotective Agent for Neurological Disorders: A Review

International Journal of Medicinal Mushrooms
Ganoderic acid A (GAA) is one of the major triterpenoids in <i>Ganoderma lucidum </i>(GL). Accumulating evidence has indicated that GAA demonstrates multiple pharmacological effects and exhibits treatment potential for various neurological disorders.
Feifei, Ma, Jing, Wang, Wenming, Jiang, Jiahao, Luo, Rui, Yang, Liying, Zhang, Chunchao, Han   +6 more
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A quantum chemical and statistical study of ganoderic acids with cytotoxicity against tumor cell

European Journal of Medicinal Chemistry, 2005
A set of molecular properties (variables) of 24 ganoderic acids with cytotoxicities against Meth-A tumor cells was calculated by the molecular orbital semi-empirical method AM1 and ChemPropStd. Pattern recognition techniques, principal component analysis (PCA) and hierarchical cluster analysis (HCA) were employed to reduce dimensionality and ...
Hai-long, Yang, Gao-hong, Chen, Yan-qun, Li   +2 more
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Enhancement of ganoderic acid production by promoting sporulation in a liquid static culture of Ganoderma species

Journal of Biotechnology, 2021
Ganoderic acids (GAs) produced by Ganoderma are a type of lanostane-type triterpenoids with anticancer and antimetastatic activities; however, low production of GAs limits its wide application. In this study, a novel strategy by promoting sporulation of Ganoderma was developed to increase GA production. First, a high-spore producing Ganoderma strain G.
Bin Sun, Hao You, Jun-Wei Xu
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Understanding the infrared and Raman spectra of ganoderic acid A: An experimental and DFT study

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019
Ganoderic Acids (GAs) are the major medicinal compounds in Ganoderma lucidum used as traditional Chinese medicine since ancient times. Ganoderic acid A (GAA) is the first discovered ganoderic acids reported in the literature, which is also one of most abundant triterpenoids of Ganoderma lucidum.
Guohua Yao, Yuhan Ma, Muhammad Muhammad, Qing Huang   +3 more
openaire   +2 more sources

Immunochromatographic strip assay for detection of bioactive Ganoderma triterpenoid, ganoderic acid A in Ganoderma lingzhi

Fitoterapia, 2016
Ganoderic acid A (GAA) is one of the major Ganoderma triterpenes produced by medicinal mushroom belonging to the genus Ganoderma (Ganodermataceae). Due to its interesting pharmacological activities, Ganoderma species have been traditionally used in China for the treatment of various diseases.
Seiichi, Sakamoto, Nao, Kikkawa, Toshitaka, Kohno, Kuniyoshi, Shimizu, Hiroyuki, Tanaka, Satoshi, Morimoto   +5 more
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Ganoderic acid a decreased Aβ42-induced neurotoxicity in PC12 cells by reduced mitochondrial damage

Brain Research
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Accumulation of β-amyloid (Aβ) in the brain has been recognized as a key factor in the onset and progression of Alzheimer's disease (AD).The accumulation of Aβ in the brain catalyzes the production of reactive oxygen species (ROS), which in turn triggers oxidative damage to cellular ...
Xiaoyuan Ding, Fan Liu, Haohao Wang, Yan Wang, Guohui Li, Xingen Zhang, Cheng Song, Fucheng Zhu, Dong Liu   +8 more
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Ganoderic acid A: an in-depth review of pharmacological effects and molecular docking analysis

Journal of Ethnopharmacology
Ganoderic acid A (GAA, C30H44O7) is one of the most abundant and active components of Ganoderic acids (GAs). GAs are highly oxidized tetracyclic triterpenoid compounds mainly derived from Ganoderma lucidum (Curtis) P. Karst (Chinese: ). GAA is primarily isolated from the fruiting body of Ganoderma lucidum.
Qi, Sui, Chengkai, Zhu, Sha, Shi, Jiaqi, Xu, Jingnan, Zhang, Ao, Wang, Peng, Chen, Guang, Liang, Yi, Zhang   +8 more
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Ganoderic acid A mitigates dopaminergic neuron ferroptosis via inhibiting NCOA4-mediated ferritinophagy in Parkinson’s disease mice

Journal of Ethnopharmacology
Ganoderma lucidum, a renowned tonic traditional Chinese medicine, is widely recognized for the exceptional activity in soothing nerves and nourishing the brain. It has been extensively employed to alleviate various neurological disorders, notably Parkinson's disease (PD).To appraise the antiparkinsonian effect of GAA, the main bioactive constituent of ...
Qiang-Ming, Li, Shu-Zhen, Wu, Xue-Qiang, Zha, Dan-Dan, Zang, Feng-Yun, Zhang, Jian-Ping, Luo   +5 more
openaire   +2 more sources