Results 171 to 180 of about 886,070 (201)

Ganoderic Acid a Potential Protective Impact on Bleomycin (BLM) -Induced lung Fibrosis in albino mice: Targeting Caveolin 1/TGF-β/ Smad and P38MAPK signaling pathway.

Archives of Biochemistry and Biophysics
BACKGROUND Bleomycin (BLM), an anticancer medication, can exacerbate pulmonary fibrosis by inducing oxidative stress and inflammation. Anti-inflammatory, anti-fibrotic, and antioxidant properties are exhibited by ganoderic acid A (GAA).
A. Elshamy, Asmaa F. El Tantawy, Eman Basha, E. Eltabaa, Heba M Arakeeb, A. S. Ahmed, Amal M. Abdelsattar, R. Ibrahim, O. S. El Deeb, A. Eid, Shaimaa S. Mashal, M. Safa, A. Shalaby, Hoda A. Ibrahim   +13 more
semanticscholar   +1 more source

Naturally derived polysaccharides and ganoderic acid A hydrogel with whitening potential to combat oxidative stress and melanin production caused by ultraviolet B.

Carbohydrate Polymers
The intersection of natural products and precision skin care has become a new trend in cosmetic development. This study developed a hydrogel composed of oxidized Tremella fuciformis polysaccharide, carboxymethyl chitosan, and Ganoderic acid A.
Tingting Ye, Tonghe Liu, Mingzhe Liu, Xudong Xu, Zhonghao Sun, Zhaocui Sun, Yong Hou, Yangyang Liu, Guoxu Ma   +8 more
semanticscholar   +1 more source

[Biosynthesis of ganoderic acid and its derivatives].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Ganoderic acid is a class of lanostane-type triterpenoids found in Ganoderma species, and is one of the most important pharmacologically active components in G. lucidum, exhibiting antioxidant, anti-neuropsychiatric, anti-tumor, and immune-enhancing properties. The content of ganoderic acid in G.
Hong-Yan, Song, Wan, Yang, Li-Wei, Liu, Xia-Ying, Cheng, Dong-Feng, Yang, Zong-Qi, Yang   +5 more
openaire   +1 more source

In Silico and In Vitro Analysis of Ganoderic Acid A Binding to Human Monocarboxylate Transporters 1 and 4

Proteins: Structure, Function, and Bioinformatics
In recent years, the search for novel anticancer agents has increasingly focused on monocarboxylate transporters (MCTs) because of their involvement in tumor metabolism. Ganoderic acid A (GAA), a triterpenoid derived from the medicinal mushroom Ganoderma
M. A. Bashir, Changsheng Shao, Mohnad Abdalla, Xin Yu, M. R. Fetisoa, Qing Huang   +5 more
semanticscholar   +1 more source

Ganoderic Acid A Modulates Enteric Neurons and Intestinal Homeostasis in Irritable Bowel Syndrome by Microbiota Sensing.

Journal of Agricultural and Food Chemistry
Irritable bowel syndrome (IBS), a common functional gastrointestinal disorder, is characterized by visceral hypersensitivity and intestinal dysmotility. Ganoderic acid A (GAA), a bioactive triterpenoid from the edible mushroom Ganoderma lucidum, has been
Rongwei Kou, Rui-Jing Zhang, Bing Xia, Gaiyan Bai, Gui-Sheng Liu, Yangqing He, Jiang-Jiang Tang, Jinming Gao   +7 more
semanticscholar   +1 more source

Afzelin resists UVA damage through autophagy and synergizes with ganoderic acid A to skin photoaging.

Phytomedicine
BACKGROUND Chronic UVA exposure accelerates photoaging by inducing oxidative stress and mitochondrial dysfunction. Autophagy maintains dermal homeostasis, but its decline promotes aging.
Jia-Hua Zou, Mei-Ling Tai, Bao-Ying Li, Jian-Jun Liu, Zhimeng Zhang, Han Wang, Dongli Zhang, Zhuang Zhou, Shanshan Feng, Manmei Li, Zhong Liu   +10 more
semanticscholar   +1 more source

Ganoderic acid A mitigates dopaminergic neuron ferroptosis via inhibiting NCOA4-mediated ferritinophagy in Parkinson's disease mice.

Journal of Ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE Ganoderma lucidum, a renowned tonic traditional Chinese medicine, is widely recognized for the exceptional activity in soothing nerves and nourishing the brain.
Qiang‐Ming Li, Shu-zhen Wu, X. Zha, Dan-Dan Zang, Feng-Yun Zhang, Jian-ping Luo   +5 more
semanticscholar   +1 more source

Ganoderic acid A alleviates metabolic dysfunction-associated fatty liver disease through attenuating steatosis and cellular apoptosis by targeting acetyl-CoA carboxylase.

International Immunopharmacology
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global metabolic epidemic with no specific effective therapy, characterized by hepatic steatosis and excessive hepatocyte apoptosis.
Yang Yao, Zhujun Liu, Xujiao Wang, Cunhao Bian, Na Yin, Xiaoyuan Peng, Siqian Qin, Rui Wang, Yukun Zhang   +8 more
semanticscholar   +1 more source

Ganoderic Acids

2003
RICHARD J. COLE, BRUCE B. JARVIS, MILBRA A. SCHWEIKERT   +2 more
openaire   +1 more source

Ganoderic acid A ameliorated LPS-induced depression-like behaviors via suppression of acute neuroinflammation

Journal of Natural Medicines
Haoran Li, Jia-xin Yue, Shaolei Luo, Hongkun Bao, Jie Bai   +4 more
semanticscholar   +1 more source