Results 171 to 180 of about 10,669 (208)
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Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer
Molecular Biology Reports, 2016Evaluating anti-oxidant potential of Ganoderic acid A in STAT 3 pathway in Prostate cancer. Molecular docking and ADMET activities of different isoforms of ganoderic acid on STAT 3 pathway were performed by Maestro 9.6 (Schrödinger Inc). The ganoderic acid A is best-docked among isoforms which analyses the expression level of antioxidant and STAT 3 ...
Balraj Singh, Gill +2 more
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Ganoderic acid A improves osteoarthritis by regulating
AbstractGanoderma mushrooms have been used to treat rheumatoid arthritis (RA) in East Asia. Whether Ganoderic acid A (GAA), the natural product extracted from Ganoderma, could be utilized to alleviate osteoarthritis (OA) is investigated in this study. Destabilization of the medial meniscus (DMM) model was constructed to reveal the in vivo effect of GAA.
Wenxiao, Wu +4 more
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Protective effect of Ganoderic acid A on adjuvant-induced arthritis
Immunology Letters, 2020The purpose of the experiment was to explore the effect of Ganoderic acid A (GAA) on adjuvant-induced arthritis in rats. In this study, the rat model of collagen-induced rheumatoid arthritis (CIA) was established with type II collagen plus Freund's complete adjuvant. Arthritis index, joint pathology, toe swelling, hemorheology, synovial cell apoptosis,
Tao, Cao +4 more
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Ganoderic Acid A Inhibits Bleomycin-Induced Lung Fibrosis in Mice
Pharmacology, 2020<b><i>Background:</i></b> To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. <b><i>Methods:</i></b> ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0.
Gaoyan, Wen +4 more
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A new ganoderic acid from Ganoderma lucidum mycelia
Journal of Asian Natural Products Research, 2010A new ganoderic acid (GA), 7-O-ethyl ganoderic acid O (GA-O) (1), together with two known compounds, GA-T (2) and GA-Me (3), was isolated and purified from fermented mycelia of Ganoderma lucidum. The structure of the new triterpenoid was elucidated on the basis of the interpretation of extensive spectroscopic data (HR-MS, IR, UV, 1D and 2D NMR) as 3 ...
Jia-Le, Wang +3 more
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Ganoderic acid, lanostanoid triterpene: a key player in apoptosis
Investigational New Drugs, 2017Cancer is a multifactorial disease, causing behavioral and metabolic alterations, leading to uncontrolled cell proliferation with collateral weakening of immune system. Crucial balance between cell proliferation and cell death determines the fate of a cell, which might progress towards survival or apoptosis.
Balraj Singh, Gill +4 more
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Ganoderic acid A against cyclophosphamide‐induced hepatic toxicity in mice
Journal of Biochemical and Molecular Toxicology, 2018AbstractThis study clarified the protective effect of ganoderic acid A (GAA) on cyclophosphamide (CP)‐induced hepatotoxicity in mice. Hepatic injury mice were induced by a single intraperitoneal injection of CP (200 mg/kg). The results showed that the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and liver of ...
Xu Lixin, Yan Lijun, Huang Songping
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Ganoderic acid Sz, a new lanostanoid from the mushroom Ganoderma lucidum
Natural Product Research, 2005A new lanostanoid, ganoderic acid SZ (1), isolated from a lipophilic extract of the fruiting body of Ganoderma lucidum, is a geometric Z-isomer of the known ganoderic acid S (2). The structure of ganoderic SZ (1) was deduced mainly by 1D and 2D NMR studies. During the course of this study, 12 known lanostanoids have also been isolated and characterized.
Canjun, Li +4 more
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A new epoxidic ganoderic acid and other phytoconstituents from Ganoderma lucidum
Phytochemistry Letters, 2011Abstract A new epoxidic ganoderic acid, 8α,9α-epoxy-3,7,11,15,23-pentaoxo-5α-lanosta-26-oic acid (1), together with the known compounds 3β-hydroxy-7,11,15,23-tetraoxo-5α-lanosta-8-en-26-oic acid (2), ergosta-7,22-diene-3β-yl pentadecanoate (3), ergosta-7,22-diene-3β-ol (4), β-sitosterol (5), fatty acids (6–10), fatty acid ester (11) and octadecane ...
Soniamol Joseph +3 more
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Ganoderic acid A protects lens epithelial cells from UVB irradiation and delays lens opacity
Chinese Journal of Natural Medicines, 2020A contributory role of oxidative stress and protection by antioxidant nutrients have been suspected in cataract formation. Ganoderic acid A (GAA), an effective lanostane triterpene, is widely reported as an antioxidant. The aim of this study is to investigate the potential effects of GAA on cataract formation.
Li-Hua, Kang +4 more
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