Results 151 to 160 of about 886,070 (201)
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Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice
Food & Function, 2021Ganoderic acid, isolated from Ganoderma lucidum , significantly ameliorated 5-FU induced cognitive impairment via preventing mitochondrial impairment and enhancing neuronal survival and growth.
Abudumijiti Abulizi +12 more
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Mitochondrial pyruvate carrier influences ganoderic acid biosynthesis in Ganoderma lucidum
Applied Microbiology and Biotechnology, 2023Mitochondrial pyruvate carriers (MPCs), located in the inner membrane of mitochondria, are essential carriers for pyruvate to enter mitochondria. MPCs regulate a wide range of intracellular metabolic processes, such as glycolysis, the tricarboxylic acid cycle (TCA cycle), fatty acid metabolism, and amino acid metabolism.
Juhong Chen +8 more
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Antioxidant potential of ganoderic acid in Notch-1 protein in neuroblastoma
Molecular and Cellular Biochemistry, 2018Neuroblastoma is a childhood tumor arising from developing a sympathetic nervous system and causes around 10% of pediatric tumors. Despite advancement in the use of sophisticated techniques in molecular biology, neuroblastoma patient's survivability rate is very less.
Balraj Singh, Gill +2 more
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A new ganoderic acid from Ganoderma lucidum mycelia and its stability
Fìtoterapìâ, 2013A new ganoderic acid (GA), 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid (1), together with four known compounds GA-Mk (2), -Mc (3), -S (4) and -Mf (5), was isolated and characterized from Ganoderma lucidum mycelia. The structure of compound 1 was elucidated on the basis of interpretation of extensive spectroscopic data (HRMS, IR, UV ...
Jian-Jiang Zhong
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Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum
European Journal of Pharmacology, 2009The preventative effects of the ethanol extracts of Ganoderma lucidum against the ovariectomized (Ovx)-induced deterioration of bone density in 11-week-old female Sprague Dawley (SD) rats were investigated. The results showed that the G. lucidum-treated Ovx rats showed improved bone density compared with the Ovx rats.
Kuniyoshi Shimizu +2 more
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Ganoderic acid A against cyclophosphamide‐induced hepatic toxicity in mice
Journal of Biochemical and Molecular Toxicology, 2018AbstractThis study clarified the protective effect of ganoderic acid A (GAA) on cyclophosphamide (CP)‐induced hepatotoxicity in mice. Hepatic injury mice were induced by a single intraperitoneal injection of CP (200 mg/kg). The results showed that the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and liver of ...
Xu Lixin, Yan Lijun, Huang Songping
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Chemical Biology and Drug Design
This study aimed to investigate the effects and mechanisms of Ganoderic acid A (GAA) on lung injury associated with systemic inflammatory response syndrome (SIRS). Forty Sprague Dawley rats were divided into four groups: Control group, GAA group (GAA, 40
Mingjie Zhu, Jianru Shang, Shan Che
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This study aimed to investigate the effects and mechanisms of Ganoderic acid A (GAA) on lung injury associated with systemic inflammatory response syndrome (SIRS). Forty Sprague Dawley rats were divided into four groups: Control group, GAA group (GAA, 40
Mingjie Zhu, Jianru Shang, Shan Che
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A new ganoderic acid from Ganoderma lucidum mycelia
Journal of Asian Natural Products Research, 2010A new ganoderic acid (GA), 7-O-ethyl ganoderic acid O (GA-O) (1), together with two known compounds, GA-T (2) and GA-Me (3), was isolated and purified from fermented mycelia of Ganoderma lucidum. The structure of the new triterpenoid was elucidated on the basis of the interpretation of extensive spectroscopic data (HR-MS, IR, UV, 1D and 2D NMR) as 3 ...
Jia-Le, Wang +3 more
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International Journal of Medicinal Mushrooms
Alzheimer's disease (AD) represents a significant challenge in neurodegenerative disorders, characterized by the accumulation of amyloid-beta (Aβ) plaques and tau protein tangles in the brain. Current treatments provide symptomatic relief but do not halt
Abuzer Ali +3 more
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Alzheimer's disease (AD) represents a significant challenge in neurodegenerative disorders, characterized by the accumulation of amyloid-beta (Aβ) plaques and tau protein tangles in the brain. Current treatments provide symptomatic relief but do not halt
Abuzer Ali +3 more
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[Pharmacokinetics of ganoderic acids].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019Ganoderic acid(GA) is one of main bioactive components produced by Ganoderma lucidum,which a traditional Chinese herbal medicine and a kind of tracyclic triterpene lanosterol derivatives with highly oxidized structure. It has a variety of important pharmacological activities,such as anticancer,immunoregulation,anti-oxidation,anti-diabetes and anti-HIV.
Fei-Fei, Zhang, Ru-Ming, Liu
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