Results 161 to 170 of about 10,014 (199)

Ganoderic acid, lanostanoid triterpene: a key player in apoptosis

Investigational New Drugs, 2017
Cancer is a multifactorial disease, causing behavioral and metabolic alterations, leading to uncontrolled cell proliferation with collateral weakening of immune system. Crucial balance between cell proliferation and cell death determines the fate of a cell, which might progress towards survival or apoptosis.
Balraj Singh, Gill, , Navgeet, Richa, Mehra, Vicky, Kumar, Sanjeev, Kumar   +4 more
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Ganoderic acid B attenuates LPS-induced lung injury

International Immunopharmacology, 2020
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a serious respiratory disease, the mechanism is unclear. This paper revealed the mechanism of ganoderic acid B (BB) on lipopolysaccharide-induced pneumonia in mice. Pneumonia model was induced by LPS in mice and A549 cells. Lung dry/wet weight (W/D) and myeloperoxidase (MPO) activity
Jiang, Shi, Huan, Wang, Jumin, Liu, Yang, Zhang, Junfang, Luo, Yan, Li, Chao, Yang, Junguang, Jiang   +7 more
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Ganoderic Acid and Lucidenic Acid (Triterpenoid)

2014
Ganoderma species is known as a functional mushroom used in many Asian countries. Triterpenoids, ganoderic acids, and lucidenic acids have been isolated from Ganoderma species (Ganodermataceae family), such as Ganoderma lucidum. Triterpenoids have been investigated for their biological activities, including antibacterial, antiviral, antitumor ...
Chin-Lin, Hsu, Gow-Chin, Yen
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Current progress in the study on biosynthesis and regulation of ganoderic acids

Applied Microbiology and Biotechnology, 2010
Ganoderic acids (GAs) isolated from Ganoderma lucidum, which have shown remarkable pharmacological activities and a variety of therapeutic effects on a number of human diseases, have provided an important resource for the development of new medicines.
Liang, Shi, Ang, Ren, Dashuai, Mu, Mingwen, Zhao   +3 more
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Ganoderic Acid A Inhibits Bleomycin-Induced Lung Fibrosis in Mice

Pharmacology, 2020
<b><i>Background:</i></b> To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. <b><i>Methods:</i></b> ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0.
Gaoyan, Wen, Tian, Li, Hua, He, Xianmei, Zhou, Jia, Zhu   +4 more
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Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice

Food & Function, 2021
Ganoderic acid, isolated from Ganoderma lucidum, significantly ameliorated 5-FU induced cognitive impairment via preventing mitochondrial impairment and enhancing neuronal survival and growth.
Abudumijiti Abulizi, Jianhua Ran, Yuwei Ye, Yongpan An, Yukun Zhang, Zhizhen Huang, Simei Lin, Hong Zhou, Dongmei Lin, Lianfu Wang, Zhibin Lin, Min Li, Baoxue Yang   +12 more
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Antioxidant potential of ganoderic acid in Notch-1 protein in neuroblastoma

Molecular and Cellular Biochemistry, 2018
Neuroblastoma is a childhood tumor arising from developing a sympathetic nervous system and causes around 10% of pediatric tumors. Despite advancement in the use of sophisticated techniques in molecular biology, neuroblastoma patient's survivability rate is very less.
Balraj Singh, Gill, , Navgeet, Sanjeev, Kumar   +2 more
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Mitochondrial pyruvate carrier influences ganoderic acid biosynthesis in Ganoderma lucidum

Applied Microbiology and Biotechnology, 2023
Mitochondrial pyruvate carriers (MPCs), located in the inner membrane of mitochondria, are essential carriers for pyruvate to enter mitochondria. MPCs regulate a wide range of intracellular metabolic processes, such as glycolysis, the tricarboxylic acid cycle (TCA cycle), fatty acid metabolism, and amino acid metabolism.
Juhong Chen, Wenzhao Xu, Zi Wang, Li Tian, Weidong Liu, Ang Ren, Rui Liu, Jing Zhu, Liang Shi   +8 more
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Ganoderic acid A against cyclophosphamide‐induced hepatic toxicity in mice

Journal of Biochemical and Molecular Toxicology, 2018
AbstractThis study clarified the protective effect of ganoderic acid A (GAA) on cyclophosphamide (CP)‐induced hepatotoxicity in mice. Hepatic injury mice were induced by a single intraperitoneal injection of CP (200 mg/kg). The results showed that the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and liver of ...
Xu Lixin, Yan Lijun, Huang Songping
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A new ganoderic acid from Ganoderma lucidum mycelia and its stability

Fìtoterapìâ, 2013
A new ganoderic acid (GA), 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid (1), together with four known compounds GA-Mk (2), -Mc (3), -S (4) and -Mf (5), was isolated and characterized from Ganoderma lucidum mycelia. The structure of compound 1 was elucidated on the basis of interpretation of extensive spectroscopic data (HRMS, IR, UV ...
Jian-Jiang Zhong
exaly   +3 more sources