Results 161 to 170 of about 886,070 (201)

Ganoderic acid A attenuates Porphyromonas gingivalis-induced adhesion molecule expression in gingival fibroblasts and tissues via inhibition of NLRP6 inflammasome activation.

Archives of Oral Biology
OBJECTIVES This study aimed to elucidate the regulatory effects and mechanisms of Ganoderic acid A (GAA) on Porphyromonas gingivalis (P. gingivalis)-induced expression of adhesion molecules in human gingival fibroblasts (hGFs) and periodontal tissues ...
Yuanbo Wang, Jian-ru Liu, Xiangying Ouyang, Wenyi Liu, Peiying Lyu, Shengnan Zhang, Jing Guo   +6 more
semanticscholar   +1 more source

Ganoderic Acid A Mitigates Inflammatory Bowel Disease through Modulation of AhR Activity by Microbial Tryptophan Metabolism.

Journal of Agricultural and Food Chemistry
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex gastrointestinal condition influenced by genetic, microbial, and environmental factors, among which the gut microbiota plays a crucial role and has emerged ...
Rongwei Kou, Zhiqing Li, Jialin Wang, Shiqi Jiang, Rui-Jing Zhang, Yangqing He, Bing Xia, Jinming Gao   +7 more
semanticscholar   +1 more source

Effects of Exogenous Salicylic Acid on Ganoderic Acid Biosynthesis and the Expression of Key Genes in the Ganoderic Acid Biosynthesis Pathway in the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes)

International Journal of Medicinal Mushrooms, 2017
We demonstrate herein that salicylic acid (SA) can enhance ganoderic acid (GA) accumulation in the lingzhi or reishi medicinal mushroom Ganoderma lucidum. Following treatment with different concentrations of SA, the GA content was increased 22.72% to 43.04% compared with the control group.
Peng-Fei, Cao, Chen-Gao, Wu, Zhi-Hao, Dang, Liang, Shi, Ai-Liang, Jiang, Ang, Ren, Ming-Wen, Zhao   +6 more
openaire   +2 more sources

Experimental and Theoretical Study of the Raman Spectra of Ganoderic Acid T

Journal of Structural Chemistry, 2019
Ganoderic acid T (GAT) has many pharmacological functions such as antitumor and antimycobacterial activity. However, to the best of our knowledge, no commercial high-purity GAT is available and the experimental and theoretical study of Raman spectrum of GAT has never been reported up to date. Therefore, in this work, GAT was extracted and purified from
H. He, G. Yao, Y. Ma, N. Feng, S. Zhou, Q. Huang   +5 more
openaire   +1 more source

Ganoderic acid A suppresses autophagy by regulating the circFLNA/miR-486-3p/CYP1A1/XRCC1 axis to strengthen the sensitivity of lung cancer cells to cisplatin.

The Journal of pharmacy and pharmacology
OBJECTIVES Reportedly, ganoderic acid A (GA-A) increases the sensitivity of hepatocellular carcinoma cells to cisplatin (DDP) chemotherapy. Therefore, this study aims to fathom the influence of GA-A on lung cancer cells.
Enhui Gong, Jiongwei Pan, Zaiting Ye, Xiaoping Cai, Hao Zheng, Z. Yin, Yiwei Jiang, Xin Wang, Z. Cao   +8 more
semanticscholar   +1 more source

Ganoderic Acid A prevents bone loss in lipopolysaccharide-treated male rats by reducing oxidative stress and inflammatory.

Chemico-Biological Interactions
Ganoderic Acid A (GAA) has demonstrated beneficial effects in anti-inflammatory and anti-oxidative stress studies. However, it remains unknown whether GAA exerts positive impacts on bone loss induced by lipopolysaccharide (LPS).
Zhou-Shan Tao, Xu-Feng Hu, Xing-jing Wu, Zheng-Yu Wang, Min Yang, Cai-Liang Shen   +5 more
semanticscholar   +1 more source

Ganoderic acid A ameliorates depressive-like behaviors in CSDS mice: Insights from proteomic profiling and molecular mechanisms.

Journal of Affective Disorders
OBJECTIVE Ganoderic Acid A (GAA), a primary bioactive component in Ganoderma, has demonstrated ameliorative effects on depressive-like behaviors in a Chronic Social Defeat Stress (CSDS) mouse model.
Jinjie Xu, Weijing Kan, Tianyi Wang, Lei Li, Yi Zhang, Ziyu Ge, Jiyi Xu, Ziyi Yin, Yuan Feng, Gang Wang, Jing Du   +10 more
semanticscholar   +1 more source

Ganoderic Acid A: A Potential Natural Neuroprotective Agent for Neurological Disorders: A Review.

International Journal of Medicinal Mushrooms
Ganoderic acid A (GAA) is one of the major triterpenoids in Ganoderma lucidum (GL). Accumulating evidence has indicated that GAA demonstrates multiple pharmacological effects and exhibits treatment potential for various neurological disorders.
Feifei Ma, Jing Wang, Wenming Jiang, Jia-Zi Luo, Rui Yang, Liying Zhang, Chunchao Han   +6 more
semanticscholar   +1 more source

Ganoderic acid a decreased Aβ42-induced neurotoxicity in PC12 cells by reduced mitochondrial damage.

Brain Research
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Accumulation of β-amyloid (Aβ) in the brain has been recognized as a key factor in the onset and progression of Alzheimer's disease (AD).The accumulation of Aβ in the brain catalyzes ...
Xiaoyuan Ding, Fan Liu, Haohao Wang, Yan Wang, Guohui Li, Xingen Zhang, Cheng Song, Fucheng Zhu, Dong Liu   +8 more
semanticscholar   +1 more source

Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum

Biotechnology Letters, 2006
Ganoderic acid, from Ganoderma lucidum, at 8 microg/ml inhibited replication of hepatitis B virus (HBV) in HepG2215 cells over 8 days. Production of HBV surface antigen and HBV e antigen were 20 and 44% of controls without ganoderic acid. Male KM mice were significantly protected from liver injury, induced with carbon tetrachloride, by treatment with ...
Yan-Qun, Li, Shun-Fa, Wang
openaire   +2 more sources