Results 141 to 150 of about 886,070 (201)

Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor

Bioorganic and Medicinal Chemistry Letters, 2009
Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5alpha-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.
Kuniyoshi Shimizu, Akiko Kukita, Ryuichiro Kondo   +2 more
exaly   +3 more sources

Protective effect of Ganoderic acid A on adjuvant-induced arthritis

Immunology Letters, 2020
The purpose of the experiment was to explore the effect of Ganoderic acid A (GAA) on adjuvant-induced arthritis in rats. In this study, the rat model of collagen-induced rheumatoid arthritis (CIA) was established with type II collagen plus Freund's complete adjuvant. Arthritis index, joint pathology, toe swelling, hemorheology, synovial cell apoptosis,
Tao, Cao, Chuanfeng, Tang, Lezhen, Xue, Mingzhu, Cui, Dan, Wang   +4 more
openaire   +2 more sources

Biotechnological production and application of ganoderic acids

Applied Microbiology and Biotechnology, 2010
Ganoderic acids (GAs), a kind of highly oxygenated lanostane-type triterpenoids, are important bioactive constituents of the famous medicinal mushroom Ganoderma lucidum. They have received wide attention in recent years due to extraordinarily pharmacological functions. Submerged fermentation of G.
Jun-Wei, Xu, Wei, Zhao, Jian-Jiang, Zhong   +2 more
openaire   +2 more sources

Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition.

Food & Function, 2022
Alcoholic liver injury is mainly caused by long-term excessive alcohol consumption and has become a global public threat to human health. It is well known that Ganoderma lucidum has excellent beneficial effects on liver function and lipid metabolism. The
Xu-Cong Lv, Qi Wu, Yingjia Cao, Yi-Chen Lin, Wei-ling Guo, P. Rao, Yan-Yan Zhang, Youting Chen, Lian-zhong Ai, Li Ni   +9 more
semanticscholar   +1 more source

Ganoderic Acid and Lucidenic Acid (Triterpenoid)

2014
Ganoderma species is known as a functional mushroom used in many Asian countries. Triterpenoids, ganoderic acids, and lucidenic acids have been isolated from Ganoderma species (Ganodermataceae family), such as Ganoderma lucidum. Triterpenoids have been investigated for their biological activities, including antibacterial, antiviral, antitumor ...
Chin-Lin, Hsu, Gow-Chin, Yen
openaire   +2 more sources

Ganoderic acid, lanostanoid triterpene: a key player in apoptosis

Investigational New Drugs, 2017
Cancer is a multifactorial disease, causing behavioral and metabolic alterations, leading to uncontrolled cell proliferation with collateral weakening of immune system. Crucial balance between cell proliferation and cell death determines the fate of a cell, which might progress towards survival or apoptosis.
Balraj Singh, Gill, , Navgeet, Richa, Mehra, Vicky, Kumar, Sanjeev, Kumar   +4 more
openaire   +2 more sources

Ganoderic acid B attenuates LPS-induced lung injury

International Immunopharmacology, 2020
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a serious respiratory disease, the mechanism is unclear. This paper revealed the mechanism of ganoderic acid B (BB) on lipopolysaccharide-induced pneumonia in mice. Pneumonia model was induced by LPS in mice and A549 cells. Lung dry/wet weight (W/D) and myeloperoxidase (MPO) activity
Jiang, Shi, Huan, Wang, Jumin, Liu, Yang, Zhang, Junfang, Luo, Yan, Li, Chao, Yang, Junguang, Jiang   +7 more
openaire   +2 more sources

Current progress in the study on biosynthesis and regulation of ganoderic acids

Applied Microbiology and Biotechnology, 2010
Ganoderic acids (GAs) isolated from Ganoderma lucidum, which have shown remarkable pharmacological activities and a variety of therapeutic effects on a number of human diseases, have provided an important resource for the development of new medicines.
Liang, Shi, Ang, Ren, Dashuai, Mu, Mingwen, Zhao   +3 more
openaire   +2 more sources

Ganoderic Acid A Inhibits Bleomycin-Induced Lung Fibrosis in Mice

Pharmacology, 2020
<b><i>Background:</i></b> To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. <b><i>Methods:</i></b> ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0.
Gaoyan, Wen, Tian, Li, Hua, He, Xianmei, Zhou, Jia, Zhu   +4 more
openaire   +2 more sources

Synergistic anti-inflammatory effects of Ganoderma lucidum polysaccharide and ganoderic acid A on LPS-induced RAW264.7 cells by inhibition of TLR4/NF-κB activation.

International Journal of Biological Macromolecules
Ganoderma lucidum, a food-grade medicinal mushroom, is rich in biologically active components that offer significant health benefits. This study investigated the synergistic anti-inflammatory effects of Ganoderma lucidum polysaccharide (GLP-1) and ...
Dongcheng Shi, Xinhui Xu, Jian Wang, Tingting Bu, Peilong Sun, Kai Yang, Ming Cai   +6 more
semanticscholar   +1 more source