Results 131 to 140 of about 6,418 (158)

A new ganoderic acid from Ganoderma lucidum mycelia

Journal of Asian Natural Products Research, 2010
A new ganoderic acid (GA), 7-O-ethyl ganoderic acid O (GA-O) (1), together with two known compounds, GA-T (2) and GA-Me (3), was isolated and purified from fermented mycelia of Ganoderma lucidum. The structure of the new triterpenoid was elucidated on the basis of the interpretation of extensive spectroscopic data (HR-MS, IR, UV, 1D and 2D NMR) as 3 ...
Jia-Le, Wang, Ying-Bo, Li, Ru-Ming, Liu, Jian-Jiang, Zhong   +3 more
openaire   +2 more sources

[Pharmacokinetics of ganoderic acids].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019
Ganoderic acid(GA) is one of main bioactive components produced by Ganoderma lucidum,which a traditional Chinese herbal medicine and a kind of tracyclic triterpene lanosterol derivatives with highly oxidized structure. It has a variety of important pharmacological activities,such as anticancer,immunoregulation,anti-oxidation,anti-diabetes and anti-HIV.
Fei-Fei, Zhang, Ru-Ming, Liu
openaire   +1 more source

Effects of Exogenous Salicylic Acid on Ganoderic Acid Biosynthesis and the Expression of Key Genes in the Ganoderic Acid Biosynthesis Pathway in the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes)

International Journal of Medicinal Mushrooms, 2017
We demonstrate herein that salicylic acid (SA) can enhance ganoderic acid (GA) accumulation in the lingzhi or reishi medicinal mushroom Ganoderma lucidum. Following treatment with different concentrations of SA, the GA content was increased 22.72% to 43.04% compared with the control group.
Peng-Fei, Cao, Chen-Gao, Wu, Zhi-Hao, Dang, Liang, Shi, Ai-Liang, Jiang, Ang, Ren, Ming-Wen, Zhao   +6 more
openaire   +2 more sources

Experimental and Theoretical Study of the Raman Spectra of Ganoderic Acid T

Journal of Structural Chemistry, 2019
Ganoderic acid T (GAT) has many pharmacological functions such as antitumor and antimycobacterial activity. However, to the best of our knowledge, no commercial high-purity GAT is available and the experimental and theoretical study of Raman spectrum of GAT has never been reported up to date. Therefore, in this work, GAT was extracted and purified from
H. He, G. Yao, Y. Ma, N. Feng, S. Zhou, Q. Huang   +5 more
openaire   +1 more source

Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum

European Journal of Pharmacology, 2009
The preventative effects of the ethanol extracts of Ganoderma lucidum against the ovariectomized (Ovx)-induced deterioration of bone density in 11-week-old female Sprague Dawley (SD) rats were investigated. The results showed that the G. lucidum-treated Ovx rats showed improved bone density compared with the Ovx rats.
Ichiko, Miyamoto, Jie, Liu, Kuniyoshi, Shimizu, Masao, Sato, Akiko, Kukita, Toshio, Kukita, Ryuichiro, Kondo   +6 more
openaire   +2 more sources

Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum

Biotechnology Letters, 2006
Ganoderic acid, from Ganoderma lucidum, at 8 microg/ml inhibited replication of hepatitis B virus (HBV) in HepG2215 cells over 8 days. Production of HBV surface antigen and HBV e antigen were 20 and 44% of controls without ganoderic acid. Male KM mice were significantly protected from liver injury, induced with carbon tetrachloride, by treatment with ...
Yan-Qun, Li, Shun-Fa, Wang
openaire   +2 more sources

A new ganoderic acid from Ganoderma lucidum mycelia and its stability

Fitoterapia, 2013
A new ganoderic acid (GA), 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid (1), together with four known compounds GA-Mk (2), -Mc (3), -S (4) and -Mf (5), was isolated and characterized from Ganoderma lucidum mycelia. The structure of compound 1 was elucidated on the basis of interpretation of extensive spectroscopic data (HRMS, IR, UV ...
Ying-Bo, Li, Ru-Ming, Liu, Jian-Jiang, Zhong   +2 more
openaire   +2 more sources

[Biosynthesis of ganoderic acid and its derivatives].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Ganoderic acid is a class of lanostane-type triterpenoids found in Ganoderma species, and is one of the most important pharmacologically active components in G. lucidum, exhibiting antioxidant, anti-neuropsychiatric, anti-tumor, and immune-enhancing properties. The content of ganoderic acid in G.
Hong-Yan, Song, Wan, Yang, Li-Wei, Liu, Xia-Ying, Cheng, Dong-Feng, Yang, Zong-Qi, Yang   +5 more
openaire   +1 more source

Targeting HSP90 destabilization with ganoderic acid a as a novel therapeutic strategy for hepatoblastoma

International Journal of Biological Macromolecules
Hepatoblastoma (HB) is the most prevalent primary liver malignancy in children and is characterized by aggressive progression and suboptimal therapeutic outcomes. Despite advances in multimodal treatment strategies, the prognosis of high-risk or relapsed HB remains poor, highlighting an urgent need for novel and effective therapeutic approaches ...
Hang, Song, Fengyuan, Chen, Shuye, Lin, Hang, Gao, Zhengrong, Zhang, Yang, Ge, Ting, Ye, Ziyu, Wang, Xingxing, Huo, Jinghui, Wang, Bin, Liu   +10 more
openaire   +2 more sources

Ganoderic acid A: an in-depth review of pharmacological effects and molecular docking analysis

Journal of Ethnopharmacology
Ganoderic acid A (GAA, C30H44O7) is one of the most abundant and active components of Ganoderic acids (GAs). GAs are highly oxidized tetracyclic triterpenoid compounds mainly derived from Ganoderma lucidum (Curtis) P. Karst (Chinese: ). GAA is primarily isolated from the fruiting body of Ganoderma lucidum.
Qi, Sui, Chengkai, Zhu, Sha, Shi, Jiaqi, Xu, Jingnan, Zhang, Ao, Wang, Peng, Chen, Guang, Liang, Yi, Zhang   +8 more
openaire   +2 more sources