The GARP complex is required for cellular sphingolipid homeostasis [PDF]
eLife, 2015 Sphingolipids are abundant membrane components and important signaling molecules in eukaryotic cells. Their levels and localization are tightly regulated. However, the mechanisms underlying this regulation remain largely unknown.
Florian Fröhlich +9 more
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The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network [PDF]
Cell Reports, 2020 Summary: Mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). However, the precise function of LRRK2 remains unclear. We report an interaction between LRRK2 and VPS52, a subunit of the Golgi-associated retrograde protein ...
Alexandra Beilina +16 more
doaj +7 more sources
A new role for the GARP complex in microRNA-mediated gene regulation. [PDF]
PLoS Genetics, 2013 Many core components of the microRNA pathway have been elucidated and knowledge of their mechanisms of action actively progresses. In contrast, factors with modulatory roles on the pathway are just starting to become known and understood. Using a genetic
Alejandro Vasquez-Rifo +5 more
doaj +6 more sources
Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b [PDF]
Cellular & Molecular Biology LettersBackground The trafficking of cargoes from endosomes to the trans-Golgi network requires numerous sequential and coordinated steps. Cargoes are sorted into endosomal-derived carriers that are transported, tethered, and fused to the trans-Golgi network ...
Jérôme Gilleron +4 more
doaj +5 more sources
The small G protein Arl5 contributes to endosome-to-Golgi traffic by aiding the recruitment of the GARP complex to the Golgi [PDF]
Biology Open, 2015 The small G proteins of the Arf family play critical roles in membrane trafficking and cytoskeleton organization. However, the function of some members of the family remains poorly understood including Arl5 which is widely conserved in eukaryotes. Humans
Cláudia Rosa-Ferreira +3 more
doaj +6 more sources
The GARP complex is required for filamentation in Candida albicans. [PDF]
Genetics, 2022 Candida albicans is an opportunistic fungal pathogen that causes superficial infections in immunocompetent individuals, as well as life-threatening systemic disease in immunocompromised patients.
Hossain S, Robbins N, Cowen LE.
europepmc +4 more sources
The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling. [PDF]
J Cell Biol, 2023 O’Brien et al. show that both the GARP and EARP complexes regulate dendrite development. Sterol accumulates specifically in GARPKO neurons at the trans-Golgi.
O'Brien CE, Younger SH, Jan LY, Jan YN.
europepmc +6 more sources
Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus Formation [PDF]
Journal of Virology, 2017 ABSTRACT Monkeypox virus (MPXV) is a human pathogen that is a member of the Orthopoxvirus genus, which includes Vaccinia virus and Variola virus (the causative agent of smallpox).
Cynthia S Goldsmith +2 more
exaly +6 more sources
The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery. [PDF]
Mol Biol Cell, 2021 The Golgi apparatus is a central hub for intracellular protein trafficking and glycosylation. Steady-state localization of glycosylation enzymes is achieved by a combination of mechanisms involving retention and vesicle recycling, but the machinery ...
Khakurel A +3 more
europepmc +5 more sources
Discovery and preclinical evaluation of BPB-101: a novel triple functional bispecific antibody targeting GARP-TGF-β complex/SLC, free TGF-β and PD-L1 [PDF]
Frontiers in ImmunologyBackgroundIn the tumor microenvironment (TME), the transforming growth factor-β (TGF-β) and programmed cell death receptor 1 (PD-1)/programmed death ligand 1 (PD-L1) signaling axes are complementary, nonredundant immunosuppressive signaling pathways ...
Wenxin Xu +12 more
doaj +3 more sources