Results 161 to 170 of about 6,644,990 (199)

Research Progress on the Immune Function of Liver Sinusoidal Endothelial Cells in Sepsis. [PDF]

Cells
Wang X, Guo Z, Xia Y, Wang X, Wang Z.
europepmc   +1 more source

Chronic Inflammation in Primary Myelofibrosis: In-Depth Insights Into Pathogenesis and Promising Anti-Inflammatory Therapeutic Strategies. [PDF]

Mediators Inflamm
Chen M, Zheng C, Zhang Y, He J, Shi Z.
europepmc   +1 more source

Health Effects of Exposure to Environmental Pollutants: The Combination of Traditional and Emerging Pollutants. [PDF]

Toxics
Chen Z, Jia G.
europepmc   +1 more source

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Changes of plasma GARP-LTGFβ1 complex during chemoradiotherapy may predict survival in non-small cell lung cancer (NSCLC).

Journal of Clinical Oncology, 2020
e21042Background: Glycoprotein-A repetitions predominant protein (GARP), a cell surface docking and activating receptor for latent transforming growth factor β1 (LTGFβ1), has been implicated in pro...
Yishan Yu, Anqi Li, Weili Wang, P. Fu, S. Jolly, T. Lawrence, M. Machtay, Zihai Li, F. Kong   +8 more
semanticscholar   +2 more sources

Hepatic stellate cells inhibit T cells through active TGFβ1 from a cell-surface-bound latent TGFβ1/GARP complex (IRM15P.609)

The Journal of Immunology, 2015
Hepatic stellate cells (HSCs) potently inhibit T cells, a process that could help the liver to maintain its immunoprivileged status. HSCs secrete latent TGFβ1, but the detailed mechanisms by which latent TGFβ1 is activated and whether it plays any role
Yan Li, B. Kim, S. Qian, J. Letterio, J. Fung, Lina L. Lu, F. Lin   +6 more
semanticscholar   +2 more sources

Yeast dynamin associates with the GARP tethering complex for endosome-to-Golgi traffic.

European Journal of Cell Biology, 2017
Yeast dynamin, Vacuolar Protein Sorting 1 (Vps1), has been implicated in recycling traffic from the endosome to the trans-Golgi network (TGN). Previous research showed a genetic interaction of Vps1 with all components of the GARP tethering complex, which anchors vesicles at the late Golgi membrane.
Uma Saimani, J. Smothers, Hyoeun McDermott, Pelin Makaraci, Kyoungtae Kim   +4 more
semanticscholar   +4 more sources

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo [PDF]

Science Translational Medicine, 2015
Monoclonal antibodies that inhibit human T reg function in vivo may be used therapeutically in cancer or infections.
Stéphanie Liénart, Bas van der Woning, Julie Stockis   +2 more
exaly   +4 more sources

Characterization of the human GARP (Golgi associated retrograde protein) complex

Experimental Cell Research, 2005
The Golgi associated retrograde protein complex (GARP) or Vps fifty-three (VFT) complex is part of cellular inter-compartmental transport systems. Here we report the identification of the VFT tethering factor complex and its interactions in mammalian cells.
Heike, Liewen, Ivo, Meinhold-Heerlein, Vasco, Oliveira, Robert, Schwarzenbacher, Guorong, Luo, Andreas, Wadle, Martin, Jung, Michael, Pfreundschuh, Frank, Stenner-Liewen   +8 more
openaire   +2 more sources

Abstract 6326: Discovery & preclinical evaluation of BPB-101: A novel triple functional bi-specific antibody targeting GARP-TGFβ complex/SLC, free TGF-β and PD-L1

Cancer Research, 2023
Background: Recent studies on tumor microenvironment (TME) have been conferred considerable attention, especially the transforming growth factor-β (TGF-β) signal axis and the PD-L1/PD-1 signal axis.
Wenxin Xu, Jieying Xu, Deyu Xu, Hongjie Cheng, Li Zhang, Hua-cheng Zheng, Siyuan Ye, Mengshi Jiang, Jiabing Wang, L. Ding   +9 more
semanticscholar   +1 more source