Results 171 to 180 of about 6,644,990 (199)

Golgi-associated retrograde protein (GARP) complex recruits retromer to trans-Golgi network for FgKex2 and FgSnc1 recycling, necessary for the development and pathogenicity of Fusarium graminearum.

New Phytologist
In eukaryotes, the retromer complex plays a crucial role in the sorting and retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN).
Yunfei Long, Xin Chen, Jia Chen, Haoran Zhang, Ying Lin, Shuyuan Cheng, Neng Pu, Xuandong Zhou, Renzhi Sheng, Y. S. Abubakar, Huawei Zheng, Yingzi Yun, G. Lu, Zonghua Wang, Wenhui Zheng   +14 more
semanticscholar   +1 more source

Suppression of lysosome metabolism-meditated GARP/TGF-β1 complexes specifically depletes regulatory T cells to inhibit breast cancer metastasis

Oncogene
Regulatory T cells (Tregs) prevent autoimmunity and contribute to cancer progression. They exert contact-dependent inhibition of immune cells through the production of active transforming growth factor-β1 (TGF-β1). However, the absence of a specific surface marker makes inhibiting the production of active TGF-β1 to specifically deplete human Tregs but ...
Jing Ma, Yutong Chen, Tao Li, Yi Cao, Bin Hu, Yuru Liu, Youran Zhang, Xiaoyan Li, Jianing Liu, Wei Zhang, Hanjing Niu, Jinhua Gao, Zhongze Zhang, Kexin Yue, Jiajia Wang, Guochen Bao, Chaojie Wang, Peng George Wang, Taotao Zou, Songqiang Xie   +19 more
openaire   +2 more sources

Targeting GARP–TGF-β1 with livmoniplimab plus anti–PD-1 budigalimab to remodel the immunosuppressive tumor microenvironment.

Journal of Clinical Oncology
2594 Background: Transforming growth factor (TGF)-β signaling has been shown to induce an immunosuppressive tumor microenvironment (TME) and promote tumor progression.
D. Dandamudi, Marion Refici, Myles Dillon, Ryan Duggan, K. Kolahi, Claire Sutherland, Catherine Tribouley, Tamar Uziel, Jack S.H. Chen   +8 more
semanticscholar   +1 more source

Faculty Opinions recommendation of The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2020
T. Galli, Somya Vats
semanticscholar   +1 more source

Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism

Signal Transduction and Targeted Therapy, 2021
Kenji Fujiwara, Stephen Muth, Jiaojiao Zhou   +2 more
exaly  

Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer

Nature Communications, 2020
Grégoire de Streel, Nicolas Chalon, Stéphanie Liénart   +2 more
exaly  

Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

Science Translational Medicine, 2020
Alessandra Metelli, Brian Riesenberg, Silvia Guglietta   +2 more
exaly  

Mapping habitat suitability for Asiatic black bear and red panda in Makalu Barun National Park of Nepal from Maxent and GARP models

Scientific Reports, 2021
Huiyi Su, Mingshi Li
exaly  

Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32

Cellular and Molecular Immunology, 2021
Bodo Grimbacher, Hendrik Schulze-Koops
exaly  

Platelets subvert T cell immunity against cancer via GARP-TGFβ axis

Science Immunology, 2017
Saleh Rachidi, Alessandra Metelli, Brian Riesenberg   +2 more
exaly