Results 21 to 30 of about 6,644,990 (199)

B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex. [PDF]

JCI Insight, 2018
GARP, a cell surface docking receptor for binding and activating latent TGF-β, is highly expressed by platelets and activated Tregs. While GARP is implicated in immune invasion in cancer, the roles of the GARP-TGF-β axis in systemic autoimmune diseases ...
C. Wallace, Bill X. Wu, M. Salem, Ephraim A. Ansa-Addo, Alessandra Metelli, Shaoli Sun, G. Gilkeson, M. Shlomchik, Bei Liu, Zihai Li   +9 more
semanticscholar   +3 more sources

The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology

Molecular Biology of the Cell, 2011
Functional characterization of the Golgi-associated retrograde protein (GARP) complex in Caenorhabditis elegans has led to the identification of the conserved metazoan Vps51 subunit.
L. Luo, M. Hannemann, Sabine Koenig, J. Hegermann, M. Ailion, Min-Kyu Cho, N. Sasidharan, M. Zweckstetter, S. Rensing, S. Eimer   +9 more
semanticscholar   +6 more sources

Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O-Glycosylation. [PDF]

Traffic
The GARP complex is an evolutionarily conserved protein complex proposed to tether endosome‐derived vesicles at the trans‐Golgi network. While complete depletion of the GARP leads to severe trafficking and glycosylation defects, the primary defects ...
Khakurel A, Pokrovskaya I, Aragon-Ramirez WS, Lupashin VV.   +3 more
europepmc   +3 more sources

ARR1 and AHP interactions in the multi-step phosphorelay system [PDF]

Frontiers in Plant Science
Plants use multi-step phosphorelay (MSP) systems in response to exogenous and endogenous stimuli. Cytokinin and ethylene are among the factors that engage MSP signaling cascades but examples independent of phytohormones also exist.
Linh H. Tran, Milosz Ruszkowski
doaj   +2 more sources

First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budigalimab in patients with advanced solid tumors

Frontiers in Oncology
BackgroundTransforming growth factor (TGF)-ß1 is a pleiotropic cytokine that can promote tumor growth and suppress antitumor immune responses. Latent TGF-ß1 associates with glycoprotein-A repetition predominant (GARP) on the surface of regulatory T cells
Toshio Shimizu, Toshio Shimizu, John Powderly, Albiruni Abdul Razak, Patricia LoRusso, Kathy D. Miller, Steven Kao, Sarah Kongpachith, Catherine Tribouley, Michelle Graham, Brian Stoll, Maulik Patel, Mohammad Sahtout, Martha Blaney, Rachel Leibman, Talia Golan, Talia Golan, Anthony Tolcher   +17 more
doaj   +2 more sources

Hematopoietic Niche Hijacking in Bone Metastases: Roles of Megakaryocytes, Erythroid Lineage Cells, and Perivascular Stromal Subsets [PDF]

Biomedicines
Bone metastases mark a critical and often terminal phase in cancer progression, where disseminated tumor cells (DTCs) manage to infiltrate and exploit the complex microenvironments of the bone marrow.
Abdul Rahman Alkhatib, Youssef Elshimy, Bilal Atassi, Khalid Said Mohammad   +3 more
doaj   +2 more sources

Control systems for membrane fusion in the ancestral eukaryote; evolution of tethering complexes and SM proteins [PDF]

BMC Evolutionary Biology, 2007
Background In membrane trafficking, the mechanisms ensuring vesicle fusion specificity remain to be fully elucidated. Early models proposed that specificity was encoded entirely by SNARE proteins; more recent models include contributions from Rab ...
Coulson Richard MR, Dacks Joel B, Koumandou V Lila, Field Mark C   +3 more
doaj   +2 more sources

T cell receptor associated transmembrane adaptor 1 (TRAT1) modulates human Th17 and Treg responses via PI3-kinase and STAT dependent mechanisms [PDF]

Cell Communication and Signaling
Background Adaptor proteins associated with the T cell receptor (TCR) play critical roles in regulating immune responses by Translating receptor engagement into intracellular signals.
Tobias Frey, Christina Kandolf-Zumpf, Anna Kaempf, Kristin Schaffer, Marlene Hollenstein, Annika Lampl, Johannes J. Kovarik, Johanna Strobl, Georg Stary, Julia Eckl-Dorna, Ralf Schmidt, Klaus G. Schmetterer   +11 more
doaj   +2 more sources

Correlation of the Expression Profile of Peripheral Leukocyte and Liver Tissue Immune Markers With Serum Liver Injury Indices in Children With Biliary Atresia [PDF]

Mediators of Inflammation
The aim of the study was to find associations between the levels of liver injury serum markers and the selected liver, peripheral leukocytes, and plasma immune characteristics in biliary atresia (BA) children. Twenty-five newly diagnosed BA children aged
Anna Helmin-Basa, Izabela Kubiszewska, Joanna B. Trojanek, Małgorzata Wiese-Szadkowska, Maria Janowska, Zbigniew Kułaga, Joanna Pawłowska, Jacek Michałkiewicz   +7 more
doaj   +2 more sources

From Genomic and Epigenomic Maps to Medicines in Adult T-Cell Leukemia/Lymphoma. [PDF]

Cancer Sci
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive and refractory hematologic malignancy that is caused by human T‐cell leukemia virus type‐1 (HTLV‐1) retrovirus. ATL results from a combination of viral latency and the accumulation of abnormalities throughout the genome, epigenome, transcriptome, and signaling pathways.
Suzuki K, Yamagishi M.
europepmc   +2 more sources