Results 31 to 40 of about 6,644,990 (199)

Dual Roles of the Mammalian GARP Complex in Tethering and SNARE Complex Assembly at the trans-Golgi Network [PDF]

Molecular and Cellular Biology, 2009
Tethering factors and SNAREs control the last two steps of vesicular trafficking: the initial interaction and the fusion, respectively, of transport vesicles with target membranes. The Golgi-associated retrograde protein (GARP) complex regulates retrograde transport from endosomes to the trans-Golgi network (TGN).
F. Pérez-Victoria, J. Bonifacino
semanticscholar   +3 more sources

GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins

Frontiers in Cell and Developmental Biology, 2022
Golgi-associated retrograde protein (GARP) is an evolutionary conserved heterotetrameric protein complex that tethers endosome-derived vesicles and is vital for Golgi glycosylation. Microscopy and proteomic approaches were employed to investigate defects
Amrita Khakurel, Tetyana Kudlyk, Irina Pokrovskaya, Zinia D’Souza, Vladimir V. Lupashin   +4 more
doaj   +1 more source

Decision letter: A systematic approach to identify recycling endocytic cargo depending on the GARP complex

, 2018
E. Miller
semanticscholar   +2 more sources

How Soluble GARP Enhances TGFβ Activation. [PDF]

PLoS ONE, 2016
GARP (glycoprotein A repetitions predominant) is a cell surface receptor on regulatory T-lymphocytes, platelets, hepatic stellate cells and certain cancer cells.
Sven Fridrich, Susanne A Hahn, Marion Linzmaier, Matthias Felten, Jenny Zwarg, Volker Lennerz, Andrea Tuettenberg, Walter Stöcker   +7 more
doaj   +1 more source

Selective targeting of GARP-LTGFβ axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity

Journal for ImmunoTherapy of Cancer, 2022
Background Immune checkpoint blockade (ICB) has revolutionized cancer immunotherapy. However, most patients with cancer fail to respond clinically. One potential reason is the accumulation of immunosuppressive transforming growth factor β (TGFβ) in the ...
Yi Wang, David Carbone, Zihai Li, Yiping Yang, Kai He, Anqi Li, Qin Ma, Yuzhou Chang, No-Joon Song, Xingjun Wu, Dongjun Chung, Brian P Riesenberg, Maria Velegraki, Giuseppe D Giuliani, Komal Das, Tamio Okimoto, Hyunwoo Kwon, Karthik B Chakravarthy, Chelsea Bolyard, Jayajit Das, Daniel T Gewirth   +20 more
doaj   +1 more source

Extracellular Vesicle–associated GARP/TGFβ:LAP Mediates “Infectious” Allo-tolerance

Transplantation Direct, 2023
Background. Here we test the hypothesis that, like CD81-associated “latent” IL35, the transforming growth factor (TGF)β:latency-associated peptide (LAP)/glycoprotein A repetitions predominant (GARP) complex was also tethered to small extracellular ...
William J. Burlingham, PhD, Ewa Jankowska-Gan, MS, John H. Fechner, MS, Christopher J. Little, MD, Jianxin Wang, PhD, Seungpyo Hong, PhD, Miraf Molla, BS, Jeremy A. Sullivan, PhD, David P. Foley, MD   +8 more
doaj   +1 more source

Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes. [PDF]

Molecular Biology of the Cell, 2008
The biosynthetic sorting of acid hydrolases to lysosomes relies on transmembrane, mannose 6-phosphate receptors (MPRs) that cycle between the TGN and endosomes. Herein we report that maintenance of this cycling requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex.
F. Pérez-Victoria, G. Mardones, J. Bonifacino   +2 more
semanticscholar   +3 more sources

Arabidopsis UNHINGED encodes a VPS51 homolog and reveals a role for the GARP complex in leaf shape and vein patterning [PDF]

Development, 2014
Asymmetric localization of PIN proteins controls directionality of auxin transport and many aspects of plant development. Directionality of PIN1 within the marginal epidermis and the presumptive veins of developing leaf primordia is crucial for establishing leaf vein pattern.
Shankar Pahari, RyanD. Cormark, Michael T. Blackshaw, Chen Liu, J. Erickson, E. Schultz   +5 more
semanticscholar   +3 more sources

Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex [PDF]

Proceedings of the National Academy of Sciences, 2010
The multisubunit Golgi-associated retrograde protein (GARP) complex is required for tethering and fusion of endosome-derived transport vesicles to the trans -Golgi network. Mutation of leucine-967 to glutamine in the Vps54 subunit of GARP is responsible for spinal muscular atrophy in the wobbler mouse, an animal ...
F. Pérez-Victoria, G. Abascal-Palacios, I. Tascón, A. Kajava, Javier G. Magadán, E. Pioro, J. Bonifacino, A. Hierro   +7 more
semanticscholar   +3 more sources

Vps54 Regulates Lifespan and Locomotor Behavior in Adult Drosophila melanogaster

Frontiers in Genetics, 2021
Vps54 is an integral subunit of the Golgi-associated retrograde protein (GARP) complex, which is involved in tethering endosome-derived vesicles to the trans-Golgi network (TGN). A destabilizing missense mutation in Vps54 causes the age-progressive motor
Emily C. Wilkinson, Emily L. Starke, Scott A. Barbee, Scott A. Barbee   +3 more
doaj   +1 more source