Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes [PDF]
Proceedings of the National Academy of Sciences, 2010 The Golgi-associated retrograde protein (GARP) complex is a membrane-tethering complex that functions in traffic from endosomes to the trans-Golgi network. Here we present the structure of a C-terminal fragment of the Vps53 subunit, important for binding endosome-derived vesicles, at a resolution of 2.9 Å.
N. Vasan +3 more
semanticscholar +3 more sources
The apple GARP family gene MdHHO3 regulates the nitrate response and leaf senescence
Frontiers in Plant Science, 2022 The regulation of plant gene expression by nitrate is a complex regulatory process. Here, we identified 90 GARP family genes in apples by genome-wide analysis.
Binbin Wen +20 more
doaj +1 more source
Revealed Price Preference: Theory and Empirical Analysis [PDF]
, 2018 With the aim of determining the welfare implications of price change in consumption data, we introduce a revealed preference relation over prices.
Deb, Rahul +3 more
core +1 more source
Domains within the GARP Subunit Vps54 Confer Separate Functions in Complex Assembly and Early Endosome Recognition [PDF]
Molecular Biology of the Cell, 2006 Tethering complexes contribute to the specificity of membrane fusion by recognizing organelle features on both donor and acceptor membranes. The Golgi-associated retrograde protein (GARP) complex is required for retrograde traffic from both early and late endosomes to the trans-Golgi network (TGN), presenting a paradox as to how a single complex can ...
Nicole R, Quenneville +3 more
openaire +2 more sources
Frontiers in Neuroscience, 2015 The wobbler mouse is an animal model for human motor neuron disease, such as amyotrophic lateral sclerosis (ALS). The spontaneous, recessive wobbler mutation causes degeneration of upper and lower motor neurons leading to progressive muscle weakness with
Thomas eSchmitt-John +1 more
doaj +1 more source
PLoS Pathogens, 2023 The advances in gene editing bring unprecedented opportunities in high throughput functional genomics to animal research. Here we describe a genome wide CRISPR knockout library, btCRISPRko.v1, targeting all protein coding genes in the cattle genome ...
Wenfang S Tan +7 more
doaj +1 more source
The function of Golgi apparatus in LRRK2-associated Parkinson’s disease
Frontiers in Molecular Neuroscience, 2023 Parkinson’s disease (PD) is a chronic neurodegenerative disease associated with the intracellular organelles. Leucine-rich repeat kinase 2 (LRRK2) is a large multi-structural domain protein, and mutation in LRRK2 is associated with PD.
Yonghang Wei +3 more
doaj +1 more source
RNF41 interacts with the VPS52 subunit of the GARP and EARP complexes
PLOS ONE, 2017 RNF41 (Ring Finger Protein 41) is an E3 ubiquitin ligase involved in the intracellular sorting and function of a diverse set of substrates. Next to BRUCE and Parkin, RNF41 can directly ubiquitinate ErbB3, IL-3, EPO and RARα receptors or downstream signaling molecules such as Myd88, TBK1 and USP8.
Delphine Masschaele +7 more
openaire +5 more sources
Corrigendum: First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP: TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budigalimab in patients with advanced solid tumors [PDF]
Frontiers in OncologyToshio Shimizu +17 more
doaj +2 more sources
Structural basis for the wobbler mouse degeneration disorder caused by mutation in the subunit of the GARP complex [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2011 I. Tascón, G. A. Palacios
semanticscholar +2 more sources