Results 211 to 220 of about 20,660 (301)

Inhibition of Gasdermin D-Mediated Pyroptosis Attenuates the Severity of Seizures and Astroglial Damage in Kainic Acid-Induced Epileptic Mice

, 2022
Lu Xia, Lu Liu, Yiying Cai, Yiying Zhang, Fangchao Tong, Qiang Wang, Jing Ding, Xin Wang   +7 more
openalex   +1 more source

Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases

Journal of Gastroenterology and Hepatology, Volume 41, Issue 3, Page 880-894, March 2026.
Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li, Jia Li, Robin P. F. Dullaart, Han Moshage   +3 more
wiley   +1 more source

IFI204 Restricts <i>Mannheimia haemolytica</i> Pneumonia via Eliciting Gasdermin D-Dependent Inflammasome Signaling. [PDF]

Microorganisms
Li JQ, Zhao Y, Li ZY, Wu YJ, Chen X, Zhang MY, Zhuang ZJ, He AB, Zhang SX, Xu Q, Sheng P, Yu SX.   +11 more
europepmc   +1 more source

Folinic Acid Improves Healing of Diabetic Foot Ulcers

Wound Repair and Regeneration, Volume 34, Issue 2, March/April 2026.
ABSTRACT A novel folinic acid (FA) wound treatment (FAWT) significantly (p < 0.05) improved healing (re‐epithelialization) of chronic diabetic foot ulcers (DFUs). In a double‐blind RCT, 10 (n = 10) chronic DFU subjects received daily topical treatment in either the Control group [(n = 5); PluroGel] or the FAWT group [(n = 5); PluroGel with FA 2.5 ...
Glenn D. Hoke, Annjanette Stone, Michael A. Bauer, Weleetka C. Carter, Megan R. Newsom, Joseph V. Boykin Jr.   +5 more
wiley   +1 more source

Improved structure of mouse gasdermin D: a new blueprint for structure-based drug design. [PDF]

Acta Crystallogr F Struct Biol Commun
De Colibus L, Ludzia P, Biasutto A, Pica A, Hopper JTS, Jazayeri A, Dürr KL.   +6 more
europepmc   +1 more source

The complicated role of neutrophil gasdermin D in sepsis

Blood, 2023
openaire   +3 more sources

RIOK2 kinase regulates the translocation of the FADD-RIPK1-Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis. [PDF]

Nat Commun
Ma M, Wang F, Cui P, Zhang Y, Ma H, He Y, Cheng Y, Huang J, Wang J, Wu X, Yang H, Zheng R, Ma H, Cai Q, Wang L, Ge B.   +15 more
europepmc   +1 more source

USP18 Antagonizes Pyroptosis by Facilitating Selective Autophagic Degradation of Gasdermin D

Liqiu Wang, Mengqiu Li, Guang‐Yu Lian, Shuai Yang, Yaoxing Wu, Jun Cui   +5 more
openalex   +1 more source

Unraveling Endocannabinoid Signaling Pathways in Cisplatin‐Induced Ototoxicity

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
We performed a comprehensive molecular profiling of the endocannabinoid (eCB) system (ECS) in an auditory Hair cell (HC)‐like cell line (1). Afterwards, we developed suitable in vitro and in vivo models of cisplatin‐induced ototoxicity where we identified distinct components of the ECS (CB2R, DAGLβ and ABHD6) as molecular targets of the drug (2 ...
Sakthimala Palaniappan, Annamaria Tisi, Camilla Di Meo, Cristina Urbano, Georgina E. Fenton, Francesco Della Valle, Federico Fanti, Dario Compagnone, Marc Nazarè, Huib Versnel, Andrea Aramini, Marcello Allegretti, Mauro Maccarrone   +12 more
wiley   +1 more source

Supporting cells orchestrate noise-induced hearing loss via a Gasdermin D-dependent signaling loop with hair cells. [PDF]

Nat Commun
Xiao L, Liu J, Chen Y, Xia L, Jiang Y, Chen X, Zhou T, Sun Y, Lu W, Wang H, Wang J, Feng Y, Zhang Z, Yin S.   +13 more
europepmc   +1 more source