Results 261 to 270 of about 20,660 (301)

Ubiquitination of gasdermin D N-terminal domain directs its membrane translocation and pore formation during pyroptosis. [PDF]

Cell Death Dis
Chu X, Zhang T, Bukhari I, Hu M, Xu J, Xing Y, Liang X, Zhang Z, Zheng P.   +8 more
europepmc   +1 more source

Role of gasdermin D in inflammatory diseases: from mechanism to therapeutics. [PDF]

Front Immunol
Cheng CK, Yi M, Wang L, Huang Y.
europepmc   +1 more source

Author response: Gasdermin D-Mediated Neutrophil Pyroptosis drives Inflammation in Psoriasis

J. Liu, Yuying Jiang, ZiYue Diao, DanDan Chen, RuiYuan Xia, BingWei Wang, Shuo Yang, Zhiqiang Yin   +7 more
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Gasdermin D kills bacteria

Microbiological Research, 2023
The recognition of pathogen- or damage- associated molecular patterns (PAMPs/DAMPs) signals a series of coordinated responses as part of innate immunity or host cell defense during infection. The inflammasome is an assemblage of multiprotein complexes in the cytosol that activate inflammatory caspases and release pro-inflammatory mediators. This review
Abosede Salami, Sahana Bettadapura, Shanzhi Wang   +2 more
openaire   +2 more sources

Gasdermin D Cleavage Assay Following Inflammasome Activation

2022
Gasdermin D (GSDMD) is a recently identified pore-forming protein that is crucial for the execution of pyroptosis, a highly inflammatory form of cell death. GSDMD contains an N-terminal and a C-terminal domain that are separated by a proteolysis-sensitive linker.
Louisa Janice, Kamajaya, Dave, Boucher
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NLRP3 inflammasome activation triggers gasdermin D–independent inflammation

Science Immunology, 2021
Sustained stimulation of the NLRP3 inflammasome causes inflammation in the absence of GSDMD.
Chun Wang, Tong Yang, Jianqiu Xiao, Canxin Xu, Yael Alippe, Kai Sun, Thirumala-Devi Kanneganti, Joseph B. Monahan, Yousef Abu-Amer, Judy Lieberman, Gabriel Mbalaviele   +10 more
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Gasdermin D opens the way for NETs

Nature Reviews Rheumatology, 2018
Gasdermin D is a pore-forming protein that can cause pyroptosis, a form of inflammatory cell death. New research indicates that the pores generated by gasdermin D can also promote the formation of neutrophil extracellular traps, potentially opening new therapeutic avenues for the treatment of inflammatory diseases.
Lotte Spel, Fabio Martinon
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Gasdermin D and pyroptosis in acute kidney injury

Kidney International, 2019
Cell death is a pathophysiological component of acute tubular necrosis and acute kidney injury. Regulated necrosis, however, comes in several different forms. Although necroptosis and ferroptosis have been recently characterized in acute kidney injury, pyroptosis has not been assessed in detail. In this issue of Kidney International, Miao and Yin et al.
Wulf, Tonnus, Andreas, Linkermann
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New insights into Gasdermin D pore formation

Biochemical Society Transactions
Gasdermin D (GSDMD) is a pore-forming protein that perforates the plasma membrane (PM) during pyroptosis, a pro-inflammatory form of cell death, to induce the unconventional secretion of inflammatory cytokines and, ultimately, cell lysis. GSDMD is activated by protease-mediated cleavage of its active N-terminal domain from the autoinhibitory C-terminal
Shirin Kappelhoff, Eleonora G. Margheritis, Katia Cosentino   +2 more
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Versatility of gasdermin D beyond pyroptosis

Trends in Cell Biology
Gasdermin D (GSDMD) has garnered significant attention primarily for the pore-forming role of its p30 N-terminal fragment (NT-p30) generated during pyroptosis, a proinflammatory form of cell death. However, emerging evidence suggests that the formation of GSDMD-NT pores is reversible, and the activation of GSDMD does not necessarily lead to pyroptosis.
Tianming Zhao, Zhexu Chi, Di Wang
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