Results 271 to 280 of about 20,660 (301)

IRF2 induces gasdermin D for pyroptosis

Science, 2019
Immunology Inflammasome activation triggers the cleavage of the protein gasdermin D. The N-terminal fragments oligomerize and form pores in the plasma membrane, leading to the release of the inflammatory cytokine interleukin-1β (IL-1β) and cell death by pyroptosis. Kayagaki et al.
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D-aring to explore: New approaches to gasdermin D targeting

Cell Chemical Biology
Novel inhibitors of pyroptosis promise breakthroughs in treating inflammatory diseases and malignant tumors. In this issue of Cell Chemical Biology, Hu et al.1 identify two repurposed drugs that selectively target gasdermin D (GSDMD) oligomers, effectively suppressing pyroptosis while reducing off-target effects typical of cysteine-based inhibitors.
Lei, Wang, Wen, Zhou
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Gasdermin D-mediated metabolic crosstalk promotes tissue repair

Nature
The establishment of an early pro-regenerative niche is crucial for tissue regeneration1,2. Gasdermin D (GSDMD)-dependent pyroptosis accounts for the release of inflammatory cytokines upon various insults3-5. However, little is known about its role in tissue regeneration followed by homeostatic maintenance. Here we show that macrophage GSDMD deficiency
Zhexu Chi, Sheng Chen, Dehang Yang, Wenyu Cui, Yang Lu, Zhen Wang, Mobai Li, Weiwei Yu, Jian Zhang, Yu Jiang, Ruya Sun, Qianzhou Yu, Tianyi Hu, Xiaoyang Lu, Qiqi Deng, Yidong Yang, Tianming Zhao, Mengfei Chang, Yuying Li, Xue Zhang, Min Shang, Qian Xiao, Kefeng Ding, Di Wang   +23 more
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Biochemical Methods for Assessing Gasdermin D Inactivation in Macrophages

2023
Gasdermin D is an essential mediator of pyroptosis. Under resting conditions gasdermin D is inactive in the cytosol. Following inflammasome activation, gasdermin D undergoes processing and oligomerization to create membrane pores and induce pyroptosis to release mature IL-1 and IL-18.
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Gasdermin D-Mediated Pyroptosis Promotes the Development of Atherosclerosis

Laboratory Investigation
Atherosclerosis is a chronic inflammatory cardiovascular disease with a high-morbidity and mortality rate. An increasing number of studies have addressed the crucial contribution of gasdermin D (GSDMD)-mediated pyroptosis, which is triggered by the inflammasomes to the development of atherosclerosis.
Bangbang Huang, Zhenhuan Zou, Yinshuang Li, Hui Chen, Kunmei Lai, Ying Yuan, Yanfang Xu   +6 more
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Gasdermin D triggers cardiolipin-driven mitochondrial damage and pyroptosis

Trends in Immunology
In a remarkable recent study, Miao et al. reveal that gasdermin D N-terminal (GSDMD-NT) instigates mitochondrial damage in pyroptosis by forming pores in inner and outer mitochondrial membranes (OMMs). The authors highlight the key role of mitochondrial cardiolipin in the action of GSDMD-NT, and significantly advance our understanding of this ...
Qiang Cai, Quazi T.H. Shubhra
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Gasdermin D pores for IL-33 release

Nature Immunology, 2022
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Controlling pyroptosis through post-translational modifications of gasdermin D

Developmental Cell
Pyroptosis, a lytic and programmed cell death pathway, is mediated by gasdermins (GSDMs), with GSDMD playing an important role in innate immunity and pathology. Upon activation, GSDMD is cleaved to release the active N-terminal fragment that oligomerizes into membrane pores, which promote pyroptosis and cytokine secretion, leading to inflammation ...
Na Zhang, Daichao Xu
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GI‐Y2, a novel gasdermin D inhibitor, attenuates sepsis‐induced myocardial dysfunction by inhibiting gasdermin D‐mediated pyroptosis in macrophages

British Journal of Pharmacology
AbstractBackground and PurposeMyocardial dysfunction is a significant complication associated with sepsis. However, there are currently no specific and effective treatments available. Inhibiting gasdermin D (GSDMD)‐mediated pyroptosis has shown promise in mitigating sepsis‐induced myocardial dysfunction.
Yiling, Mei, Xudong, Chen, Si, Shi, Wante, Lin, Zhenfeng, Cheng, Xiaoxi, Fan, Wenqi, Wu, Jibo, Han, Weijian, Huang, Bozhi, Ye, Shanshan, Dai   +10 more
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Gasdermin D inhibitor protects against sepsis

Nature Reviews Drug Discovery, 2020
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