Role of gasdermins in chronic kidney disease [PDF]
Frontiers in ImmunologyGasdermins (GSDMs), functioning as membrane perforating proteins, can be activated by canonical inflammasomes, noncanonical inflammasomes, as well as non-inflammasomes, leading to cell pyroptosis and the subsequent release of inflammatory mediators ...
Hanchao Gao +11 more
doaj +7 more sources
Frontiers in Immunology, 2023 Sepsis is a hyper-heterogeneous syndrome in which the systemic inflammatory response persists throughout the course of the disease and the inflammatory and immune responses are dynamically altered at different pathogenic stages.
Wenhua Wang, Zhihui He, Zhihui He
doaj +5 more sources
Corrigendum: Pyroptosis and gasdermins—Emerging insights and therapeutic opportunities in metabolic dysfunction-associated steatohepatitis [PDF]
Frontiers in Cell and Developmental Biology[This corrects the article DOI: 10.3389/fcell.2023.1218807.]
Christian Stoess +4 more
doaj +6 more sources
Editorial: Gasdermins in the defense against pathogens [PDF]
Frontiers in Immunology, 2023 Leopold Eckhart, Ruochan Chen
doaj +7 more sources
Diagnostic and prognostic value of the gasdermins in gastric cancer [PDF]
Brazilian Journal of Medical and Biological ResearchPyroptosis has attracted attention due to its role in various cancers. Recently, gasdermins (GSDMs) involved in pyroptosis have been reported to be associated with several types of cancers.
Yeqiong Xu +7 more
doaj +3 more sources
Caspase-1 activates gasdermin A in non-mammals [PDF]
eLifeGasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E.
Zachary Paul Billman +5 more
doaj +5 more sources
Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation [PDF]
Nature Communications, 2019 Gasdermins mediate lytic cell death by forming pores in the plasma membrane. Here the authors show that gasdermins also permeabilize mitochondrial membrane, thereby facilitating intrinsic apoptosis pathway, downstream of apoptotic (Gasdermin E) and ...
Corey Rogers +5 more
doaj +4 more sources
Emerging insights on the role of gasdermins in infection and inflammatory diseases [PDF]
Clinical & Translational Immunology, 2020 The gasdermins, family of pore‐forming proteins, are emerging key regulators of infection, autoinflammation and antitumor immunity. Multiple studies have recently characterised their crucial roles in driving pyroptosis, a lytic pro‐inflammatory type of ...
Lipeng Tang +3 more
doaj +2 more sources
Pyroptosis and gasdermins—Emerging insights and therapeutic opportunities in metabolic dysfunction-associated steatohepatitis [PDF]
Frontiers in Cell and Developmental Biology, 2023 In recent years, there has been a rapid expansion in our understanding of regulated cell death, leading to the discovery of novel mechanisms that govern diverse cell death pathways.
Christian Stoess +4 more
doaj +3 more sources
Pyroptosis Modulators: New Insights of Gasdermins in Health and Disease [PDF]
Antioxidants, 2023 Pyroptosis is an inflammation-dependent type of cell death that has been in the spotlight for the scientific community in the last few years. Crucial players in the process of pyroptosis are the members of the gasdermin family of proteins, which have ...
Imane Allali-Boumara +4 more
doaj +2 more sources