Frontiers in Immunology, 2023 Sepsis is a hyper-heterogeneous syndrome in which the systemic inflammatory response persists throughout the course of the disease and the inflammatory and immune responses are dynamically altered at different pathogenic stages.
Wenhua Wang, Zhihui He, Zhihui He
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Role of gasdermins in chronic kidney disease [PDF]
Frontiers in ImmunologyGasdermins (GSDMs), functioning as membrane perforating proteins, can be activated by canonical inflammasomes, noncanonical inflammasomes, as well as non-inflammasomes, leading to cell pyroptosis and the subsequent release of inflammatory mediators ...
Hanchao Gao +11 more
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Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation [PDF]
Nature Communications, 2019 Gasdermins mediate lytic cell death by forming pores in the plasma membrane. Here the authors show that gasdermins also permeabilize mitochondrial membrane, thereby facilitating intrinsic apoptosis pathway, downstream of apoptotic (Gasdermin E) and ...
Corey Rogers +5 more
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Emerging insights on the role of gasdermins in infection and inflammatory diseases [PDF]
Clinical & Translational Immunology, 2020 The gasdermins, family of pore‐forming proteins, are emerging key regulators of infection, autoinflammation and antitumor immunity. Multiple studies have recently characterised their crucial roles in driving pyroptosis, a lytic pro‐inflammatory type of ...
Lipeng Tang +3 more
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Editorial: Gasdermins in the defense against pathogens [PDF]
Frontiers in Immunology, 2023 Leopold Eckhart, Ruochan Chen
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Pyroptosis and gasdermins—Emerging insights and therapeutic opportunities in metabolic dysfunction-associated steatohepatitis [PDF]
Frontiers in Cell and Developmental Biology, 2023 In recent years, there has been a rapid expansion in our understanding of regulated cell death, leading to the discovery of novel mechanisms that govern diverse cell death pathways.
Christian Stoess +4 more
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Role of Caspases and Gasdermin A during HSV-1 Infection in Mice [PDF]
Viruses, 2022 Herpes simplex virus type 1 (HSV-1) infection can manifest locally as mucocutaneous lesions or keratitis and can also spread to the central nervous system to cause encephalitis.
Lupeng Li +5 more
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Gasdermins: Effectors of Pyroptosis [PDF]
Trends in Cell Biology, 2017 Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase-11/4/5, which cleave gasdermin D, separating its N-terminal pore-forming ...
Kovacs, Stephen B., Miao, Edward A.
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Corrigendum: Pyroptosis and gasdermins—Emerging insights and therapeutic opportunities in metabolic dysfunction-associated steatohepatitis [PDF]
Frontiers in Cell and Developmental Biology[This corrects the article DOI: 10.3389/fcell.2023.1218807.]
Christian Stoess +4 more
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Gasdermins: novel mitochondrial pore-forming proteins [PDF]
Molecular & Cellular Oncology, 2019 Gasdermin proteins have been extensively characterized for their ability to form necrotic pores in the plasma membrane, however, their interactions with other organelles have yet to be described.
Corey Rogers, Emad S. Alnemri
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