Results 121 to 130 of about 849 (195)

Gasdermin D mediates a fast transient release of ATP after NLRP3 inflammasome activation before ninjurin 1-induced lytic cell death [PDF]

Pyroptosis is a lytic cell death triggered by the cleavage of gasdermin (GSDM) proteins and subsequent pore formation by the N-terminal domain oligomerization in the plasma membrane.
Angosto-Bazarra, Diego, Guijarro, Adriana, Hurtado-Navarro, Laura, Meunier, Etienne, Pelegrin, P, Perez-Oliva, Ana Belen, Pinilla, Miriam, Schachter, Julieta, Schwarzbaum, Pablo J   +8 more
core   +1 more source

The Multifaceted Role of Calcium Signaling in Regulated Necrosis [PDF]

Calcium is a versatile ion that regulates diverse intracellular processes, including cell death and survival, cytokine and chemokine production, lipid scrambling, and immune cell activation.
Perez-Rivera, E. , Plasencia, C., Ros, U.   +2 more
core   +1 more source

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source

Expression characteristics of dual‐specificity phosphatase 2 and hypoxia‐inducible factor‐1α in acute kidney injury and preliminary study of the effect of dual‐specificity phosphatase 2 on HK‐2 cells

Experimental Physiology, EarlyView.
ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu, Songmin Xue, Lanyan Lin, Xuan Huang, Sisi Chen, Wulaer Adeli, Zulibiya Tuohetiyaer, Suhua Li, Chen Lu   +8 more
wiley   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

TAK1 inhibition activates pore-forming proteins to block intracellular bacterial growth through modulating mitochondria

Cell Death and Disease
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), known as TAK1, is a central mediator of intracellular host defense signaling promoting inflammatory gene expression. Hence, TAK1 is a prime target of intracellular bacterial effectors in blocking
Wilfred López-Pérez, Roland E. González-Calderón, Kazuhito Sai, Prashant Rai, Jacqueline M. MacStudy, Yosuke Sakamachi, Cameron Parsons, Sophia Kathariou, Michael B. Fessler, Jun Ninomiya-Tsuji   +9 more
doaj   +1 more source

Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death

Journal of Lipid Research
Sterol-regulatory element binding proteins (SREBPs) are a conserved transcription factor family governing lipid metabolism. When cellular cholesterol level is low, SREBP2 is transported from the endoplasmic reticulum to the Golgi apparatus where it ...
Yanni Xiong, Jie Luo, Zi-Yun Hong, Wen-Zhuo Zhu, Ao Hu, Bao-Liang Song   +5 more
doaj   +1 more source

Rolle des durch Gasdermin E vermittelten Zelltods bei kolorektaler Karzinogenese [PDF]

Der Zelltod hat zentrale Funktionen in der Entwicklung und in der Homöostase adulter Gewebestrukturen. Dabei werden dysregulierte Zelltodprozesse mit der Entstehung zahlreicher menschlicher Krankheiten, einschließlich Krebs und Entzündungen in Verbindung
Zhang, Jiajia
core   +2 more sources

LIN‐24 as a Molecular Switch: Dual Cytotoxic and Cytoprotective Roles of an Aerolysin‐Like Protein in C. elegans

Journal of Applied Toxicology, Volume 46, Issue 4, Page 1076-1082, April 2026.
ABSTRACT LIN‐24, an aerolysin‐like pore‐forming protein in Caenorhabditis elegans, exemplifies how ancient cytolytic mechanisms have evolved into regulated cellular processes. Initially identified for inducing nonapoptotic, engulfment‐dependent cell death in vulval precursor cells, LIN‐24 has emerged as a multifunctional regulator of metabolism, stress
Sharoen Yu Ming Lim
wiley   +1 more source

Gut Commensal Klebsiella pneumoniae Extracellular Vesicles Shape a Liver Microenvironment Conducive to Gut‐Liver Bacterial Translocation and Pro‐Tumorigenic Processes

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Bacterial extracellular vesicles (EVs) are emerging mediators of host–microbe communication; however, their role in human disease remains unclear. Here, we identify two bacterial small tRNAs (tsRNAs) enriched in gut commensal Klebsiella pneumoniae‐derived EVs (KpEVs) that are markedly elevated in the serum of patients with hepatocellular ...
Shogo Tsubaki, Sho Nashimoto, Rika Tanaka, Touya Toyomoto, Hiroyasu Tsutsuki, Ken Kato, Jun Nakayama, Kiminori Kimura, Kazuki Oshima, Yusuke Yamamoto, Takuji Okusaka, Minoru Esaki, Nobuhiro Kawai, Nobuyuki Ota, Yusuke Yoshioka, Takahiro Ochiya, Yoshimasa Saito, Tomohiro Sawa, Katsuto Hozumi, Juntaro Matsuzaki, Hitoshi Tsugawa   +20 more
wiley   +1 more source