Results 131 to 140 of about 849 (195)

Editorial: Role of pyroptosis in neurological disorders and its therapeutic approaches

Frontiers in Aging Neuroscience, 2023
Jing Wu, Nelli Mnatsakanyan, Muhuo Ji
doaj   +1 more source

The Open Reading Frame 7b of the SARS‐CoV‐2 Disperse Trans‐Golgi and Activate the NLRP3 Inflammasome

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Inflammasomes orchestrate the inflammatory response against bacterial and viral infections, thereby initiating the synthesis of pro‐inflammatory cytokines, mainly IL‐1β and IL‐18. SARS‐CoV‐2 infection induces an inflammatory response mediated by the activation of NLRP1 and NLRP3 inflammasomes.
Julio García‐Villalba, Laura Hurtado‐Navarro, Diego Angosto‐Bazarra, Alberto Baroja‐Mazo, Pablo Pelegrin   +4 more
wiley   +1 more source

Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma [PDF]

Background: Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for therapeutic development remain less understood ...
Chen, Shufen, Chen, Siyun, Feng, Yu, Kerr, David, Kwong, Tsz Tung, La Thangue, Nick, Leung, Howard, Liang, Jianxin, Liang, Liying, Liang, Zhixian, Lin, Yingnan, Liu, Yan, Lu, Jiahuan, Ren, Weida, Si-Tou, Willis Wai-Yiu, To, Ka Fai, Tu, Yalin, Vong, Joaquim S L, Wang, Jing, Wong, Patrick Pak-Chun, Wu, Haoran, Xiong, Zhewen, Yang, Weiqin, Yin, Baoyi, Zhang, Lingyun, Zhong, Chengpeng   +25 more
core   +2 more sources

Characterization of NLRP3 isoforms in bullfrog Aquarana catesbeiana and their role in antibacterial immunity

Journal of the World Aquaculture Society, Volume 57, Issue 2, April 2026.
Abstract The NLRP3 inflammasome is essential for innate immunity against pathogens, yet its function in amphibians remains poorly understood. Here, we identified and cloned two novel isoforms of NLRP3 from the American bullfrog (Aquarana catesbeiana), designated AcNLRP3 X1 and AcNLRP3 X2, with open reading frames of 2397 bp (798 aa) and 2874 bp (957 aa)
Peikui Yang, Jiayi Chen, Yixian Lin, Boxi Zeng, Tongying Chen, Jude Juventus Aweya, Xianghui Zou, Yuzhong Zheng, Ruixuan Wang   +8 more
wiley   +1 more source

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, Volume 13, Issue 16, 18 March 2026.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Gasdermins in neurodegeneration: emerging mechanisms and therapeutic targets

Cell Death and Disease
Gasdermins (GSDM) are pore-forming proteins that mediate pyroptosis, an inflammatory form of programmed cell death characterized by membrane permeabilization and the release of intracellular contents.
Sizhuo Chen, Jing Zhang, Xin Chen, Zhongmeng Lai, Zhenhuan Zhao, Shao-bin Wang   +5 more
doaj   +1 more source

Cloning and Characterization of Three Alleles of the Mouse Furloss (Frl) Gene [PDF]

, 2005
Single-gene mutations in the mouse serve as useful models for understanding the pathophysiology and molecular mechanisms of human diseases. Three dominant autosomal mutations affecting skin, hair and eye development in the mouse were recovered in ...
Dech, Heather Marie
core   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, Volume 13, Issue 18, 27 March 2026.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source