Results 141 to 150 of about 849 (195)

Lytic coelomocyte death is tuned by cleavage but not phosphorylation of MLKL in echinoderms.

PLoS Pathogens
Lytic cell death including necroptosis and pyroptosis is induced by mixed lineage kinase domain-like protein (MLKL) phosphorylation and inflammatory caspase specific cleavage Gasdermins in higher mammals, respectively.
Kaiyu Chen, Sikou Shen, Zhimeng Lv, Ming Guo, Yina Shao, Chenghua Li   +5 more
doaj   +1 more source

Gasdermin D and Gasdermin E Are Dispensable for Silica-Mediated IL-1β Secretion from Mouse Macrophages

ImmunoHorizons
Abstract Silica crystals activate the NLRP3 inflammasome in macrophages, resulting in the caspase-1–dependent secretion of the proinflammatory cytokine IL-1β. Caspase-1–mediated cleavage of gasdermin D (GSDMD) triggers the formation of GSDMD pores, which drive pyroptotic cell death and facilitate the rapid release of IL-1β.
Jennifer Leung, Michael Chang, Richard E Moore, Jargalsaikhan Dagvadorj, Fayyaz S Sutterwala, Suzanne L Cassel   +5 more
openaire   +2 more sources

Click Chemistry and Bioorthogonal Reaction for Aggregation‐Induced Emission Bioconjugates

Aggregate, Volume 7, Issue 3, March 2026.
This review highlights the construction of AIE active bioconjugates via click chemical or bioorthogonal reactions, and their applications in biosensing, bioimaging, and image‐guided treatment. The challenges and perspectives in the area are also discussed.
Xinzhe Yang, Miaomiao Kang, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

Diverse Scaffolds Facilitate NLRP3 Clustering and Inflammasome Formation in Response to Perturbations in Cell Homeostasis

BioEssays, Volume 48, Issue 3, March 2026.
NLRP3, a cytosolic innate immune sensor, responds to diverse activators that perturb cellular homeostasis. These disturbances generate molecular scaffolds that, through binding partners such as nucleic acids, lipids, and proteins, recruit and concentrate NLRP3. Scaffold‐mediated NLRP3 clustering promotes NLRP3 inflammasome assembly.
Elvira Boršić‐Mlinarič, Iva Hafner‐Bratkovič   +1 more
wiley   +1 more source

Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia. [PDF]

, 2018
In a large scale screen for skin, hair, and nail abnormalities in null mice generated by The Jackson Laboratory\u27s KOMP center, homozygous mutant Far2tm2b(KOMP)Wtsi/2J (hereafter referrred to as Far2-/-) mice were found to develop focal areas of ...
Bechtold, Lesley S, Dionne, Louise A, Fiehn, Oliver, Gott, Nicholas E, Kennedy, Victoria E, Kuiper, Raoul, Murray, Stephen A, Pratt, C Herbert, Rice, Robert H, Shen, Tong, Silva, Kathleen A, Sundberg, John P   +11 more
core   +1 more source

Cell‐Type‐Specific WTAP and ALKBH5‐Mediated m6A Methylation Orchestrates Mental Disorders via Gut‐Brain Axis Metabolite Signaling: Multi‐Omics Evidence and Pyroptosis‐Associated Loop Mechanism

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
MR analysis revealed distinct causal associations of m6A modifiers (WTAP/ALKBH5) with mental disorders. Gut microbiota (GCA‐900066755, Bacillus) and CSF metabolites (theophylline, isoleucine) mediated 5.06%–45.28% of effects via pathways such as WTAP → GCA‐900066755 → theophylline → ADHD. Single‐cell eQTL linked WTAP‐mediated ADHD risk to XCL1‐NK cells,
Jingjing Zhang, Xue Liu, Xiaoming Liu, Liqun Zhao, Junjie Bi   +4 more
wiley   +1 more source

Macrophage‐derived galectin‐3 contributes to pyroptosis, apoptosis and necroptosis through TLR4/MyD88/NF‐κB/NLRP3 during atherosclerosis

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
Pyroptosis, apoptosis and necroptosis of macrophages occur concurrently during atherosclerosis. Galetein‐3 and NLRP3 are highly expressed in atherosclerotic lesions. Galectin‐3 is principally expressed in macrophages within atherosclerotic plaques. Galectin‐3 interacts with NLRP3, activates TLR4/MyD88/NF‐κB/NLRP3 signal axis, and promotes PANoptosis ...
Zihui Yuan, Haitao Li, Bing Xing Ruan, Hongyi Huang, Yiqing Li, Jian Wang   +5 more
wiley   +1 more source

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source

Ninjurin1 in cardiovascular and vascular biology: From molecular mechanisms to therapeutic opportunities

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
NINJ1 mediates PMR in cardiovascular cell death, releasing DAMPs that amplify vascular inflammation. Dual NINJ1 paradox: membrane‐bound form drives endothelial NF‐κB/CXCL‐8 inflammation while soluble form provides atheroprotection. Pericyte NINJ1 regulates the critical balance between angiogenic sprouting and vessel maturation in ischaemic tissues ...
Muhammad Mamunur Rashid Mahib
wiley   +1 more source

Non‐HLA Risk Loci ERBB3/IKZF4 and ERBB2/IKZF3/GSDMB/ORMDL3 Interact to Influence Progression of Autoimmunity in Relatives of T1D Patients

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 3, March 2026.
ABSTRACT Aim The genetic loci, ERBB2/IKZF3/GSDMB/ORMDL3 on chromosome 17q, and ERBB3/IKZF4 on chromosome 12q represent confirmed non‐HLA risk factors for the development of autoimmunity and progression to type 1 diabetes (T1D). It is unknown whether both regions can interact to influence the progression of T1D.
Ina M. Mertens, Bart Keymeulen, Frans K. Gorus, Mark Van De Casteele, the Belgian Diabetes Registry   +4 more
wiley   +1 more source