Results 141 to 150 of about 3,607 (251)
Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren +4 more
wiley +1 more source
Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin +10 more
wiley +1 more source
Molecular characterization of a fungal gasdermin-like protein [PDF]
, 2020 Asen Daskalov +4 more
openalex +1 more source
Aging Cell, Volume 25, Issue 2, February 2026.This work proposes ferroptosis as a mechanistic driver of age‐related muscle dysfunction, whereby iron dyshomeostasis and impaired antioxidant capacity promote lipid peroxidation, and eventually trigger ferroptosis, leading to muscle wasting, and ultimately contributing to weakness and functional decline with aging.
Rola S. Zeidan +6 more
wiley +1 more source
Experimental Physiology, Volume 111, Issue 2, Page 489-500, 1 February 2026.Abstract Type 2 diabetes mellitus (T2DM) significantly increases the risk and severity of cerebral ischaemia–reperfusion (IR) injury, yet effective neuroprotective treatments for diabetic stroke remain limited. This study explored whether a combination of sinomenine and metformin could offer enhanced neuroprotection in diabetic rats subjected to ...
Wendi Li +2 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 1, 15 January 2026.Schematic diagram of the triggering mechanism of necroptosis after cerebral ischemia. First, CCL11 targetedly binds to CCR3 on the surface of astrocytes and upregulates the expression of CCR3. After CCR3 activation, it triggers the transcriptional activation of necroptosis.
Han Yin +10 more
wiley +1 more source
Rolle des durch Gasdermin E vermittelten Zelltods bei kolorektaler Karzinogenese [PDF]
Der Zelltod hat zentrale Funktionen in der Entwicklung und in der Homöostase adulter Gewebestrukturen. Dabei werden dysregulierte Zelltodprozesse mit der Entstehung zahlreicher menschlicher Krankheiten, einschließlich Krebs und Entzündungen in Verbindung
Zhang, Jiajia
core +2 more sources
Editorial: Role of pyroptosis in neurological disorders and its therapeutic approaches
Frontiers in Aging Neuroscience, 2023 Jing Wu, Nelli Mnatsakanyan, Muhuo Ji
doaj +1 more source
Mechanistic Insights into Gasdermin Pore Formation and Regulation in Pyroptosis
, 2021 Chengliang Wang, Jianbin Ruan
openalex +2 more sources
The expression profile of Gasdermin C-related genes predicts the prognosis and immunotherapy response of pancreatic adenocarcinoma. [PDF]
, 2023 Xiang-Hou Xia +11 more
openalex