Results 151 to 160 of about 849 (195)

Cardamonin Commands the Colonic Metabolite Columbianetin Acetate to Compete Against LPS in Binding HMGB1 in the Kidney, Preventing Lipopolysaccharide‐Induced Renal Tubular Pyroptosis

Food Frontiers, Volume 7, Issue 2, March 2026.
Cardamonin upregulate sd the intestinal metabolite columbianetin acetate, which competitively bound HMGB1 to prevent LPS‐induced renal tubular cell pyroptosis (the figure is created with BioRender). ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) results in high mortality due to the lack of effective interventions. The current study reports the
Zihui Zhou, Xuechun Sun, Jian Zhou, Huali Meng, Pengfei Fan, Yufeng Chu, Hao Wu   +6 more
wiley   +1 more source

Dihydromyricetin Regulates PANoptosis to Protect Salmonella Typhimurium‐Infected Weaned Piglets

Food Frontiers, Volume 7, Issue 2, March 2026.
After DHM pretreatment, piglets were subjected to Salmonella infection. Serum and ileocecal samples from the piglets were collected for TUNEL assay, Western blotting analysis, and metabolomics analysis. The results collectively indicated that DHM could protect piglets from Salmonella infection.
Tingting Xiao, Xinyi Tian, YiKun Li, Jie Zhang, Hongcan Huang, Yu‐Xuan Lyu, Baichuan Deng   +6 more
wiley   +1 more source

Non‐Starch Purple Sweet Potato Polysaccharide Ameliorates Lipopolysaccharides‐Induced Acute Colitis by Regulating Gut Function and Inactivating the NOD‐Like Receptor Protein 3 Signaling Pathway

Food Frontiers, Volume 7, Issue 2, March 2026.
Purple sweet potato polysaccharide (PSP) ameliorates lipopolysaccharide‐induced ulcerative colitis in mice through multiple coordinated mechanisms. Oral PSP administration dose‐dependently: (1) Modulates gut microbiota composition and increases short‐chain fatty acid levels; (2) strengthens intestinal barrier function; (3) attenuates systemic ...
Peng Yu, Jitao Ling, Yixuan Chen, Panpan Xia, Yuting Wu, Jianqi Liang, Xuehong Zheng, Yunkun Liu, Zhou Xu, Yiming Gan, Ao Shi, Wenting Wang, Xiao Liu, Yaqi Rong, Yan Xiong, Jianping Liu, Xiaoping Yin, Jing Zhang, Deju Zhang   +18 more
wiley   +1 more source

Characterization of Novel Pathogenic Variants Leading to Caspase-8 Cleavage-Resistant RIPK1-Induced Autoinflammatory Syndrome [PDF]

Pathogenic RIPK1 variants have been described as the cause of two different inborn errors of immunity. Biallelic loss-of-function variants cause the recessively inherited RIPK1 deficiency, while monoallelic variants impairing the caspase-8-mediated RIPK1
Angosto Bazarra, Diego, Aróstegui Gorospe, Juan Ignacio, Baroja Mazo, Alberto, Baños, María C., Cabral, Marta, Casals López, Ferran, Fabregat, Virginia, Figueiredo, Antonio E., Lobato Salinas, Zulema, Martins, Andreia L., Mensa Vilaró, Anna, Oliva, Baldomero, Ortiz de Landazuri, Iñaki, Pelegrín, Pablo, Plaza, Susana, Tapiz i Reula, Alfonso José, Virgil Cochino, Alexis, Yagüe, Jordi   +17 more
core  

Extracellular Vesicles‐Functionalized Biomaterials for Oral Disease Theragnostics

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
Combining EVs with biomaterials enables sustained, targeted delivery and overcomes traditional limitations. EVs show great promise in diagnosing and treating oral diseases, and could transform oral health management strategies. ABSTRACT Oral diseases impair oral function and are closely linked to various systemic conditions.
Zhe Zhao, Yiyu Zeng, Rui Liu, Xuemei Qiu
wiley   +1 more source

Editorial: Macrophage Plasticity in Sterile and Pathogen-Induced Inflammation. [PDF]

, 2021
Hewitson, J., Kourtzelis, I., Roger, T.
core   +1 more source

The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities

MedComm, Volume 7, Issue 3, March 2026.
Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou, Shilong Jiang, Hui Li, Kai Zhao, Dongshen Cao, Guoping Yang   +5 more
wiley   +1 more source

The killer protein Gasdermin D [PDF]

Cell Death & Differentiation, 2016
John A Wright, Clare E Bryant
openaire   +1 more source

Does pyroptotic cell death contribute to anthracycline-induced cardiotoxicity? [PDF]

Background: Anthracyclines are widely used as effective chemotherapeutic agents. However, research has found that anthracycline-induced cardiotoxicity (AIC) causes significant morbidity and mortality.
Salim, Handi Yuwono
core  

Therapeutic Efficacy of the Supersulfide Donor NAC‐S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses

Microbiology and Immunology, Volume 70, Issue 3, Page 148-159, March 2026.
ABSTRACT Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic, and anti‐inflammatory activities; however, their therapeutic potential after disease onset ...
Foysal Hossen, Takahisa Kouwaki, Yukio Fujiwara, Hiroyasu Tsutsuki, Tianli Zhang, Chunyu Guo, Azizur Rahman, Yoshihiro Komohara, Hiroyuki Oshiumi, Tomohiro Sawa   +9 more
wiley   +1 more source