Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma [PDF]
Background: Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for therapeutic development remain less understood ...
Chen, Shufen +25 more
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Lytic coelomocyte death is tuned by cleavage but not phosphorylation of MLKL in echinoderms.
PLoS PathogensLytic cell death including necroptosis and pyroptosis is induced by mixed lineage kinase domain-like protein (MLKL) phosphorylation and inflammatory caspase specific cleavage Gasdermins in higher mammals, respectively.
Kaiyu Chen +5 more
doaj +1 more source
Iron induces B cell pyroptosis through Tom20–Bax–caspase–gasdermin E signaling to promote inflammation post-spinal cord injury [PDF]
, 2023 Chengjie Wu +12 more
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Cloning and Characterization of Three Alleles of the Mouse Furloss (Frl) Gene [PDF]
, 2005 Single-gene mutations in the mouse serve as useful models for understanding the pathophysiology and molecular mechanisms of human diseases. Three dominant autosomal mutations affecting skin, hair and eye development in the mouse were recovered in ...
Dech, Heather Marie
core +1 more source
ImmunoHorizonsAbstract Silica crystals activate the NLRP3 inflammasome in macrophages, resulting in the caspase-1–dependent secretion of the proinflammatory cytokine IL-1β. Caspase-1–mediated cleavage of gasdermin D (GSDMD) triggers the formation of GSDMD pores, which drive pyroptotic cell death and facilitate the rapid release of IL-1β.
Jennifer Leung +5 more
openaire +2 more sources
Gasdermin D unlocks metabolic pathways to enhance tissue regeneration [PDF]
Quazi T.H. Shubhra
openalex +1 more source
Gasdermin D–mediated pyroptosis suppresses liver regeneration after 70% partial hepatectomy
, 2022 Xingyu Lv +8 more
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Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia. [PDF]
, 2018 In a large scale screen for skin, hair, and nail abnormalities in null mice generated by The Jackson Laboratory\u27s KOMP center, homozygous mutant Far2tm2b(KOMP)Wtsi/2J (hereafter referrred to as Far2-/-) mice were found to develop focal areas of ...
Bechtold, Lesley S +11 more
core +1 more source
Gasdermin D‐Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis [PDF]
C Liu +10 more
openalex +1 more source