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Mechanisms of Gasdermin Recognition by Proteases
Journal of Molecular Biology, 2022Members of the gasdermin family contain positively charged N-terminal domains (NTDs) capable of binding phospholipids and assembling membrane pores, and C-terminal domains (CTDs) that bind the NTDs to prevent pore formation in the resting states. The flexible NTD-CTD linker regions of gasdermins are highly variable in length and sequences, which may be
Zhonghua, Liu +3 more
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Transcriptional and Epigenetic Regulation of Gasdermins
Journal of Molecular Biology, 2022Gasdermins (GSDM) are a family of six homologous proteins (GSDMA to E and Pejvakin) in humans. GSDMA-E are pore-forming proteins targeting the plasma membrane to trigger a rapid cell death termed pyroptosis or bacterial membranes to promote antibacterial immune defenses.
Emilie, Bourdonnay, Thomas, Henry
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Gasdermins: making pores for pyroptosis
Nature Reviews Immunology, 2021Feng Shao highlights the studies that led to the discovery and definition of pyroptosis as gasdermin-mediated programmed necrotic cell death.
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Inflammasome and gasdermin signaling in neutrophils
Molecular Microbiology, 2022AbstractInflammasomes and gasdermins mount potent host defense pathways against invading microbial pathogens, however, dysregulation in these pathways can drive a variety of inflammatory disorders. Neutrophils, historically regarded as effector phagocytes that drive host defense via microbial killing, are now emerging as critical drivers of immunity in
See Jie Yow +2 more
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Gasdermin D Cleavage Assay Following Inflammasome Activation
2022Gasdermin D (GSDMD) is a recently identified pore-forming protein that is crucial for the execution of pyroptosis, a highly inflammatory form of cell death. GSDMD contains an N-terminal and a C-terminal domain that are separated by a proteolysis-sensitive linker.
Louisa Janice, Kamajaya, Dave, Boucher
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Versatility of gasdermin D beyond pyroptosis
Trends in Cell BiologyGasdermin D (GSDMD) has garnered significant attention primarily for the pore-forming role of its p30 N-terminal fragment (NT-p30) generated during pyroptosis, a proinflammatory form of cell death. However, emerging evidence suggests that the formation of GSDMD-NT pores is reversible, and the activation of GSDMD does not necessarily lead to pyroptosis.
Tianming Zhao, Zhexu Chi, Di Wang
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Mechanistic insights into gasdermin-mediated pyroptosis
Nature Reviews Molecular Cell BiologyPyroptosis, a novel mode of inflammatory cell death, is executed by membrane pore-forming gasdermin (GSDM) family members in response to extracellular or intracellular injury cues and is characterized by a ballooning cell morphology, plasma membrane rupture and the release of inflammatory mediators such as interleukin-1β (IL-1β), IL-18 and high ...
Yang Bai, Youdong Pan, Xing Liu
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Gasdermins in pyroptosis, inflammation, and cancer
Trends in Molecular MedicinePyroptosis is a type of programmed inflammatory cell death characterized by balloon-like swelling, membrane rupture, and the release of inflammatory cytokines and danger signals. Pyroptosis is directly triggered by activated gasdermins (GSDMs) which bind to membrane phospholipids, oligomerize, and form pores in cell membranes.
Rui Min +3 more
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