Role of Caspases and Gasdermin A during HSV-1 Infection in Mice [PDF]
Viruses, 2022 Herpes simplex virus type 1 (HSV-1) infection can manifest locally as mucocutaneous lesions or keratitis and can also spread to the central nervous system to cause encephalitis.
Lupeng Li +5 more
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Staphylococcus aureus induces Gasdermin A-dependent keratinocyte pyroptosis [PDF]
Nature CommunicationsStaphylococcus aureus is a common colonizer of human skin, which, despite its ubiquitous nature, has a high virulence potential. Tolerating microbes in health but responding effectively to pathogens presents a challenge to the barrier tissues.
Doris L. LaRock +6 more
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Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release. [PDF]
Proc Natl Acad Sci U S AGasdermin D (GSDMD)-mediated pyroptotic cell death drives inflammatory cytokine release and downstream immune responses upon inflammasome activation, which play important roles in host defense and inflammatory disorders. Upon activation by proteases, the
Liu Z +12 more
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TAK1 inhibition activates pore-forming proteins to block intracellular bacterial growth through modulating mitochondria [PDF]
Cell Death and DiseaseMitogen-activated protein kinase kinase kinase 7 (MAP3K7), known as TAK1, is a central mediator of intracellular host defense signaling promoting inflammatory gene expression. Hence, TAK1 is a prime target of intracellular bacterial effectors in blocking
Wilfred López-Pérez +9 more
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Gasdermins in neurodegeneration: emerging mechanisms and therapeutic targets [PDF]
Cell Death and DiseaseGasdermins (GSDM) are pore-forming proteins that mediate pyroptosis, an inflammatory form of programmed cell death characterized by membrane permeabilization and the release of intracellular contents.
Sizhuo Chen +5 more
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Pyroptosis, inflammasome, and gasdermins in tumor immunity
Innate Immunity, 2023 The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A (GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD), gasdermin E (GSDME) and DFNB59 (Pejvakin (PJVK)) in humans.
Xiaohu Ouyang +5 more
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Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death [PDF]
Journal of Lipid ResearchSterol-regulatory element binding proteins (SREBPs) are a conserved transcription factor family governing lipid metabolism. When cellular cholesterol level is low, SREBP2 is transported from the endoplasmic reticulum to the Golgi apparatus where it ...
Yanni Xiong +5 more
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Gasdermins: novel mitochondrial pore-forming proteins [PDF]
Molecular & Cellular Oncology, 2019 Gasdermin proteins have been extensively characterized for their ability to form necrotic pores in the plasma membrane, however, their interactions with other organelles have yet to be described.
Corey Rogers, Emad S. Alnemri
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Gasdermins: a dual role in pyroptosis and tumor immunity [PDF]
Frontiers in ImmunologyThe gasdermin (GSDM) protein family plays a pivotal role in pyroptosis, a process critical to the body’s immune response, particularly in combatting bacterial infections, impeding tumor invasion, and contributing to the pathogenesis of various ...
Jiayi Yang +5 more
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Gasdermin A (GSDMA) Tissue Expression, Serum and Urinary Concentrations with Clinicopathologic Outcome in Psoriasis. [PDF]
Dermatol Pract ConceptIntroduction: Psoriasis is a frequent and incurable skin disease that is an important issue in contemporary dermatology, whereas its pathogenesis is still uncertain.
Nowowiejska J +6 more
europepmc +3 more sources