Results 21 to 30 of about 849 (195)
Gasdermin-B (GSDMB) takes center stage in antibacterial defense, inflammatory diseases, and cancer [PDF]
, 2023 One of the hottest topics in biomedical research is to decipher the functional implications of the Gasdermin (GSDM) protein family in human pathologies.
Colomo del Pino, Sara +2 more
core +1 more source
Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells [PDF]
, 2023 Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si lo hubiere, y los autores pertenecientes a la UAMGasdermin (GSDM)-mediated pyroptosis is functionally involved ...
Colomo del Pino, Sara +2 more
core +4 more sources
Acta Pharmaceutica Sinica B, 2021 Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host against microbe infection. Excessive pyroptosis, however, leads to several inflammatory diseases, including sepsis and autoimmune disorders. Pyroptosis can be canonical or noncanonical.
Brandon E. Burdette +3 more
openaire +3 more sources
Induction of pyroptotic cell death as a potential tool for cancer treatment [PDF]
, 2022 Cancer is a complex pathological disease and the existing strategies for introducing chemotherapeutic agents have restricted potential due to a lack of cancer cell targeting specificity, cytotoxicity, bioavailability, and induction of multi-drug ...
Cordeiro de Lima, Vladmir Claudio +5 more
core +1 more source
Pyroptosis: the dawn of a new era in endometrial cancer treatment
Frontiers in Oncology, 2023 Endometrial cancer (EC) is a malignancy of the inner epithelial lining of the uterus. While early-stage EC is often curable through surgery, the management of advanced, recurrent and metastatic EC poses significant challenges and is associated with a ...
Tian Peng +8 more
doaj +1 more source
Porous insights: IpaH7.8 reveals crystal-clear differences of gasdermins in mice and men [PDF]
, 2023 Two recent back-to-back papers published in Nature provide new insights into the structural basis of gasdermin B (GSDMB) targeting by the secreted Shigella virulence effector IpaH7.8, the regulation of GSDMB ’ s pore-forming pyroptotic activity by ...
Kolbrink, Benedikt +2 more
core +1 more source
Pyroptosis in spinal cord injury
Frontiers in Cellular Neuroscience, 2022 Spinal cord injury (SCI) often brings devastating consequences to patients and their families. Pathophysiologically, the primary insult causes irreversible damage to neurons and glial cells and initiates the secondary damage cascade, further leading to ...
Jian Yin +4 more
doaj +1 more source
Gasdermins pore cell membrane to pyroptosis [PDF]
Science China Life Sciences, 2016 Huanhuan Liang, Yingfang Liu
core +4 more sources
Frontiers in Immunology, 2022 Pyroptosis is a proinflammatory programmed cell death pathway mediated by gasdermins. Exploring the role of pyroptosis can provide new insights into tumor malignancy. The most recent studies on pyroptosis have focused on tumor cells. However, the effects
Yonghua Cai +15 more
doaj +1 more source
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on GSDMB (gasdermin B), with data on DNA, on the protein encoded, and where the gene is implicated.
Tamura, M, Shiroishi, T
openaire +2 more sources