Results 21 to 30 of about 3,607 (251)
Novel pyroptosis-independent functions of gasdermins
Signal Transduction and Targeted Therapy, 2022 Ziran Qin, Fangfang Zhou, Long Zhang
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Pyroptosis, gasdermins and allergic diseases. [PDF]
AllergyAbstractPyroptosis is an inflammatory form of programmed cell death that is distinct from necrosis and apoptosis. Pyroptosis is primarily mediated by the gasdermin family of proteins (GSDMA‐E and PVJK), which, when activated by proteolytic cleavage, form pores in the plasma membrane, leading to cell death.
Panganiban RA, Nadeau KC, Lu Q.
europepmc +3 more sources
Modulation of Autoimmune and Autoinflammatory Diseases by Gasdermins
Frontiers in Immunology, 2022 Autoimmune diseases and autoinflammatory diseases are two types of the immune system disorders. Pyroptosis, a highly inflammatory cell death, plays an important role in diseases of immune system.
Fang Liang +3 more
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Gasdermins: the hole picture emerges [PDF]
Nature Reviews Immunology, 2016 Yvonne Bordon
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Pyroptosis in development, inflammation and disease
Frontiers in Immunology, 2022 In the early 2000s, caspase-1, an important molecule that has been shown to be involved in the regulation of inflammation, cell survival and diseases, was given a new function: regulating a new mode of cell death that was later defined as pyroptosis ...
Yuhong Pan +18 more
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Gasdermin D and Beyond – Gasdermin-mediated Pyroptosis in Bacterial Infections
Journal of Molecular Biology, 2022 The discovery of pyroptosis and its subsequent implications in infection and immunity has uncovered a new angle of host-defence against pathogen assault. At its most simple, gasdermin-mediated pyroptosis in bacterial infection would be expected to remove pathogens from the relative safety of the cytosol or pathogen containing vacuole/phagosome whilst ...
Lee M, Booty, Clare E, Bryant
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An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis.
PLoS Biology, 2023 The gasdermins are a family of pore-forming proteins involved in various cellular processes such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary history of gasdermins across metazoans, highlighting the conservation ...
Chengliang Wang, Jianbin Ruan
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Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores [PDF]
, 2023 Viral sensing in myeloid cells involves inflammasome activation leading to gasdermin pore formation, cytokine release, and cell death. However, less is known about viral sensing in barrier epithelial cells, which are critical to the innate immune ...
Baran, Marcin +4 more
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Gasdermin-B (GSDMB) takes center stage in antibacterial defense, inflammatory diseases, and cancer [PDF]
, 2023 One of the hottest topics in biomedical research is to decipher the functional implications of the Gasdermin (GSDM) protein family in human pathologies.
Colomo del Pino, Sara +2 more
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Acta Pharmaceutica Sinica B, 2021 Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host against microbe infection. Excessive pyroptosis, however, leads to several inflammatory diseases, including sepsis and autoimmune disorders. Pyroptosis can be canonical or noncanonical.
Brandon E. Burdette +3 more
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