Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases
Cell Reports, 2021 Summary: Cellular inflammasome activation causes caspase-1 cleavage of the pore-forming protein gasdermin D (GSDMD) with subsequent pyroptotic cell death and cytokine release.
Bowen Zhou, Derek W. Abbott
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on GSDMA (gasdermin A), with data on DNA, on the protein encoded, and where the gene is implicated.
Saeki, N, Sasaki, H
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Unconventional protein secretion by gasdermin pores [PDF]
Seminars in Immunology, 2023 Unconventional protein secretion (UPS) allows the release of specific leaderless proteins independently of the classical endoplasmic reticulum (ER)-Golgi secretory pathway. While it remains one of the least understood mechanisms in cell biology, UPS plays an essential role in immunity as it controls the release of the IL-1 family of cytokines, which ...
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Gasdermins assemble; recent developments in bacteriology and pharmacology
Frontiers in Immunology, 2023 The discovery of gasdermin D (GSDMD) as the terminal executioner of pyroptosis provided a large piece of the cell death puzzle, whilst simultaneously and firmly putting the gasdermin family into the limelight.
Claudine S. Greenwood +4 more
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Investigating the Crime Scene-Molecular Signatures in Inflammatory Bowel Disease [PDF]
, 2023 Inflammatory bowel diseases (IBD) are without cure and troublesome to manage because of the considerable diversity between patients and the lack of reliable biomarkers.
Andersen, Vibeke +7 more
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The Role of lncRNA-Mediated Pyroptosis in Cardiovascular Diseases [PDF]
, 2023 Cardiovascular disease (CVD) is the leading cause of death worldwide. Pyroptosis is a unique kind of programmed cell death that varies from apoptosis and necrosis morphologically, mechanistically, and pathophysiologically.
Claudia Camacho +7 more
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Инфламмасомы и пироптоз эпителиальных клеток кишечника: вклад в развитие болезни Крона и неспецифического язвенного колита [PDF]
, 2019 ИНФЛАММАСОМЫПИРОПТОЗКЛЕТКИ СМЕРТЬЭПИТЕЛИОЦИТЫЭПИТЕЛИАЛЬНЫЕ КЛЕТКИКИШЕЧНИКА ВОСПАЛИТЕЛЬНЫЕ БОЛЕЗНИКРОНА БОЛЕЗНЬИЛЕИТ РЕГИОНАЛЬНЫЙИЛЕИТ ТЕРМИНАЛЬНЫЙИЛЕОКОЛИТЭНТЕРИТ ГРАНУЛОМАТОЗНЫЙКОЛИТ ЯЗВЕННЫЙПРОКТОКОЛИТ ЯЗВЕННЫЙПРОКТОЛИТ ГЕМОРРАГИЧЕСКИЙРЕКТОКОЛИТ ...
Ткаченко, А. С.
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The multifaceted roles of gasdermins in cancer biology and oncologic therapies [PDF]
, 2021 The involvement of the Gasdermin (GSDM) protein family in cancer and other pathologies is one of the hottest topics in biomedical research. There are six GSDMs in humans (GSDMA, B, C, D, GSDME/DFNA5 and PJVK/ DFNB59) and, except PJVK, they can trigger ...
Martinez-Val, Jeannette +4 more
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Posttranslational and Therapeutic Control of Gasdermin-Mediated Pyroptosis and Inflammation
Frontiers in Immunology, 2021 Pyroptosis is a proinflammatory form of cell death, mediated by membrane pore-forming proteins called gasdermins. Gasdermin pores allow the release of the pro-inflammatory cytokines IL-1β and IL-18 and cause cell swelling and cell lysis leading to ...
Fabian A. Fischer +2 more
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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death [PDF]
, 2016 Pyroptosis is a lytic type of cell death that is initiated by inflammatory caspases. These caspases are activated within multi-protein inflammasome complexes that assemble in response to pathogens and endogenous danger signals.
Broz, Petr +9 more
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