Results 31 to 40 of about 3,607 (251)
Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells [PDF]
, 2023 Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si lo hubiere, y los autores pertenecientes a la UAMGasdermin (GSDM)-mediated pyroptosis is functionally involved ...
Colomo del Pino, Sara +2 more
core +4 more sources
Induction of pyroptotic cell death as a potential tool for cancer treatment [PDF]
, 2022 Cancer is a complex pathological disease and the existing strategies for introducing chemotherapeutic agents have restricted potential due to a lack of cancer cell targeting specificity, cytotoxicity, bioavailability, and induction of multi-drug ...
Cordeiro de Lima, Vladmir Claudio +5 more
core +1 more source
Gasdermins assemble; recent developments in bacteriology and pharmacology
Frontiers in Immunology, 2023 The discovery of gasdermin D (GSDMD) as the terminal executioner of pyroptosis provided a large piece of the cell death puzzle, whilst simultaneously and firmly putting the gasdermin family into the limelight.
Claudine S. Greenwood +4 more
doaj +1 more source
Porous insights: IpaH7.8 reveals crystal-clear differences of gasdermins in mice and men [PDF]
, 2023 Two recent back-to-back papers published in Nature provide new insights into the structural basis of gasdermin B (GSDMB) targeting by the secreted Shigella virulence effector IpaH7.8, the regulation of GSDMB ’ s pore-forming pyroptotic activity by ...
Kolbrink, Benedikt +2 more
core +1 more source
Pyroptosis: the dawn of a new era in endometrial cancer treatment
Frontiers in Oncology, 2023 Endometrial cancer (EC) is a malignancy of the inner epithelial lining of the uterus. While early-stage EC is often curable through surgery, the management of advanced, recurrent and metastatic EC poses significant challenges and is associated with a ...
Tian Peng +8 more
doaj +1 more source
CARD domains mediate anti-phage defence in bacterial gasdermin systems. [PDF]
NatureWein T +12 more
europepmc +3 more sources
Single-Cell Genetic Mapping of Gasdermin Expression Across Immune-Mediated Inflammatory Diseases. [PDF]
FASEB JThis figure illustrates the lineage‐specific causal effects of gasdermin (GSDM) expression on the risk of eight immune‐mediated inflammatory diseases (IMIDs). The analysis, based on single‐cell genetic data, shows how GSDMA, GSDMB, and GSDMD affect disease risk in various immune cell types, highlighting distinct protective or risk‐enhancing roles in ...
Gao X, Guo X, Yin K, Jin X.
europepmc +2 more sources
Gasdermins: Effectors of Pyroptosis [PDF]
Trends in Cell Biology, 2017 Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase-11/4/5, which cleave gasdermin D, separating its N-terminal pore-forming domain (PFD) from the C-terminal repressor domain (RD).
Miao, Edward A., Kovacs, Stephen B.
openaire +2 more sources
Pyroptosis in spinal cord injury
Frontiers in Cellular Neuroscience, 2022 Spinal cord injury (SCI) often brings devastating consequences to patients and their families. Pathophysiologically, the primary insult causes irreversible damage to neurons and glial cells and initiates the secondary damage cascade, further leading to ...
Jian Yin +4 more
doaj +1 more source
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on GSDMB (gasdermin B), with data on DNA, on the protein encoded, and where the gene is implicated.
Tamura, M, Shiroishi, T
openaire +2 more sources