Results 51 to 60 of about 3,607 (251)
Reconstitution of human pyroptotic cell death in Saccharomyces cerevisiae
Scientific Reports, 2023 Pyroptosis is a lytic form of programmed cell death induced by the activation of gasdermins. The precise mechanism of gasdermin activation by upstream proteases remains incompletely understood.
Yanhao Ji, Christine J. Hawkins
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Frontiers in Immunology, 2021 Inflammasomes are fundamental innate immune mechanisms that promote inflammation and induce an inflammatory form of programmed cell death, pyroptosis. Pyroptotic inflammasome has been reported to be closely associated with tumorigenesis and prognosis of ...
Ying Li +9 more
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INFLAMMASOMES AND GASDERMINS IN IMMUNE DEFENSE AND PATHOLOGY [PDF]
, 2021 Pyroptosis is a form of programmed cell death that effectively defends against intracellular pathogens by lysing an infected cell, thereby removing the pathogens’ replicative niche, and by releasing danger-associated molecular patterns and the pro ...
Kovacs, Stephen Bela
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Targeting gasdermin E in neurodegenerative diseases
Cell Reports Medicine, 2023 Neel et al. identified pathophysiologic clues linking gasdermin-E (GSDME) with frontotemporal dementia and amyotrophic lateral sclerosis.1 Therapeutic studies targeting GSDME may provide a viable approach for neurodegenerative diseases.
Zhou, Zhi Dong +2 more
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Partners in Crime: The Interplay of Proteins and Membranes in Regulated Necrosis [PDF]
, 2020 Pyroptosis, necroptosis, and ferroptosis are well-characterized forms of regulated necrosis that have been associated with human diseases. During regulated necrosis, plasma membrane damage facilitates the movement of ions and molecules across the bilayer,
Garcia Saez, A. +2 more
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Gasdermins pore cell membrane to pyroptosis [PDF]
Science China Life Sciences, 2016 Huanhuan Liang, Yingfang Liu
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Gasdermins: New Therapeutic Targets in Host Defense, Inflammatory Diseases, and Cancer
Frontiers in Immunology, 2022 Gasdermins (GSDMs) are a class of pore-forming proteins related to pyroptosis, a programmed cell death pathway that is induced by a range of inflammatory stimuli. Small-scale GSDM activation and pore formation allow the passive release of cytokines, such
Laura Magnani +2 more
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Biological Functions of Gasdermins in Cancer: From Molecular Mechanisms to Therapeutic Potential
Frontiers in Cell and Developmental Biology, 2021 Pyroptosis is a type of lytic programmed cell death triggered by various inflammasomes that sense danger signals. Pyroptosis has recently attracted great attention owing to its contributory role in cancer.
Man Wang, Xinzhe Chen, Yuan Zhang
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Role of Pyroptosis in Respiratory Diseases and its Therapeutic Potential
Journal of Inflammation Research, 2022 Jingjing Liu,1– 3 Guoqing Fan,1– 3 Ningning Tao,4 Tieying Sun1,2 1Department of Respiratory Medicine and Critical Care, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing ...
Liu J, Fan G, Tao N, Sun T
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Cells, 2022 About thirty years ago, a new form of pro-inflammatory lytic cell death was observed and termed pyroptosis. Only in 2015, gasdermins were defined as molecules that create pores at the plasma membrane and drive pyroptosis.
Benjamin Demarco +3 more
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