The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Gasdermins: pore-forming activities and beyond [PDF]
Acta Biochimica et Biophysica Sinica, 2020 Gasdermins (GSDMs) belong to a protein superfamily that is found only in vertebrates and consists of GSDMA, GSDMB, GSDMC, GSDMD, DFNA5 (a.k.a. GSDME) and DFNB59 (a.k.a. Pejvakin (PJVK)) in humans. Except for DFNB59, all members of the GSDM superfamily contain a conserved two-domain structure (N-terminal and C-terminal domains) and share an ...
Zengzhang, Zheng +7 more
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Emerging roles of the gasdermin family in asthma [PDF]
Kosin Medical JournalAsthma is a chronic and heterogeneous airway disease resulting from a complex interplay among genetic predisposition, environmental exposures, and immune dysregulation.
Marina Miller, Gil-Soon Choi
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Molecular and structural aspects of gasdermin family pores and insights into gasdermin-elicited programmed cell death [PDF]
Biochemical Society Transactions, 2021 Pyroptosis is a highly inflammatory and lytic type of programmed cell death (PCD) commenced by inflammasomes, which sense perturbations in the cytosolic environment. Recently, several ground-breaking studies have linked a family of pore-forming proteins known as gasdermins (GSDMs) to pyroptosis.
Ayesha Zahid +2 more
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Pyroptosis and Its Role in SARS-CoV-2 Infection
Cells, 2022 The pore-forming inflammatory cell death pathway, pyroptosis, was first described in the early 1990s and its role in health and disease has been intensively studied since.
Zsofia Agnes Bittner +3 more
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Jefferson Digital Commons quarterly report: January-March 2020 [PDF]
, 2020 This quarterly report includes: New Look for the Jefferson Digital Commons Articles COVID-19 Working Papers Educational Materials From the Archives Grand Rounds and Lectures JeffMD Scholarly Inquiry Abstracts Journals and Newsletters Master of Public ...
Copeland, LIBT, James +2 more
core +1 more source
Pyroptosis in Neutrophils: Multimodal Integration of Inflammasome and Regulated Cell Death Signaling Pathways [PDF]
, 2023 Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma membrane (PM) macropores composed of gasdermin-family (GSDM) proteins.
Dubyak, George R +2 more
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Targeting 7KCh-Induced Cell Death Response Mediated by p38, P2X7 and GSDME in Retinal Pigment Epithelium Cells with Sterculic Acid [PDF]
, 2023 Age-related macular degeneration (AMD) is the main cause of blindness in developed countries. AMD is characterized by the formation of drusen, which are lipidic deposits, between retinal pigment epithelium (RPE) and the choroid. One of the main molecules
0000-0001-9046-6629 +8 more
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‘Hints’ in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death [PDF]
Cell Death & Differentiation, 2017 Pyroptosis is a lytic form of cell death distinguished from apoptosis, ferroptosis, necrosis, necroptosis, NETosis, oncosis, pyronecrosis and autophagy. Proinflammatory caspases cleave a gasdermin D (GSDMD) protein to generate a 31 kDa N-terminal domain.
Qiu, Shiqiao, Liu, Jing, Xing, Feiyue
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To Kill But Not Be Killed: Controlling the Activity of Mammalian Pore-Forming Proteins
Frontiers in Immunology, 2020 Pore-forming proteins (PFPs) are present in all domains of life, and play an important role in host-pathogen warfare and in the elimination of cancers.
Patrycja A. Krawczyk +2 more
doaj +1 more source