Results 121 to 130 of about 39,803 (247)

Imeglimin suppresses glucagon secretion and induces a loss of α cell identity

Cell Reports Medicine
Summary: Dysregulated α cell function contributes to the development of diabetes. In this study, we find that treatment with imeglimin, an antidiabetic drug, prevents glucagon release and induces a loss of α cell identity through direct action on α cells.
Takahiro Tsuno, Jinghe Li, Kuniyuki Nishiyama, Yuka Imamura Kawasawa, Ryota Inoue, Esther Ong Yajima, Akira Nishiyama, Shigeharu G. Yabe, Tatsuya Kin, Hitoshi Okochi, Tomohiko Tamura, A.M. James Shapiro, Seiichi Oyadomari, Tadahiro Kitamura, Yasuo Terauchi, Jun Shirakawa   +15 more
doaj   +1 more source

Effects of intraduodenally applied bile salts on pancreatic secretion [PDF]

, 1993
Lehnert, Peter, Riepl, Rudolf L.
core   +1 more source

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

Control of energy homeostasis by amylin [PDF]

, 2018
Amylin is an important control of nutrient fluxes because it reduces energy intake, modulates nutrient utilization by inhibiting postprandial glucagon secretion, and increases energy disposal by preventing compensatory decreases of energy expenditure in ...
Lutz, Thomas
core  

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Bidirectional Interactions Between the Gut Microbiota and Incretin-Based Therapies

Life
Obesity, insulin resistance, type 2 diabetes mellitus (T2DM) and metabolic syndrome have been largely correlated to a reduction in bacterial load and diversity, resulting in a condition known as intestinal dysbiosis.
Vincenzo Trapanese, Annamaria Dagostino, Maria Resilde Natale, Federica Giofrè, Clara Vatalaro, Melania Melina, Francesca Cosentino, Silvia Sergi, Felice Imoletti, Rocco Spagnuolo, Franco Arturi   +10 more
doaj   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

The Brain‐Gut Axis in Parkinson's Disease Pathology

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Exposure to environmental toxins induces gut dysbiosis, increases intestinal epithelial barrier permeability, immune activation, and oxidative stress, promoting α‐syn misfolding and propagation. Brainstem DMV neurons exhibit α‐syn pathology, dysregulating neuronal excitability and vagal control of GI functions.
Kudret Selin Ozkaya, Kirsteen N. Browning   +1 more
wiley   +1 more source

The Mediators of Bile Action on the Exocrine Pancreas [PDF]

, 1993
Baba N, Beauchamp R D, Björnsson O G, Bondesen S, Burhol P G, Burhol P G, Burhol P G, Burhol P G, Chayvialle J A, Chey W Y, Davies H A, Domschke S, Fahrenkrug J, Feurle G E, Fiedler F, Fiedler F, Flaten O, Forell M M, Forell M M, Fölsch U R, Gomez G, Gomez G, Gomez G, Gomez G, Greeley G H, Grundy S M, Hanssen L E, Hanssen L E, Hanssen L E, Hoist J J, Hoist J J, Hoist J J, Häcki W H, Imamura M, Imamura M, Khalil T, Konturek S J, Koop I, Koop I, Koop I, Koop I, Koop I, Koop I, Koop I, Larsson L I, Layer P, Lehnert P, Londong W, Londong W, Lonovics J, Malagelada J R, Mellanby J, Miyasaka K, Nakaba H, Nakamura R, Nakamura R, Nustede R, Ohta H, Osnes M, Osnes M, Osnes M, P. Lehnert, Petersen H, R. L. Riepl, Rhodes J, Riepl R L, Riepl R L, Riepl R L, Sakamoto T, Schaffalitzky de Muckadell O B, Schwartz T W, Shiratori K, Singer M V, Singer M V, Singer M V, Solomon T E, Tsuchiya T   +76 more
core   +1 more source

Investigation of ACE and DPP‐IV Inhibitory Potential of Peptides Obtained From Hazelnut Protein Hydrolysates in Food Supplement Applications

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Production of peptide molecules from hazelnut cake using proteolytic enzymes and ultrafiltration methods. Exploration of antioxidant activities, DPP‐IV and ACE inhibitory properties of these molecules and their evaluation in food supplement applications.
Sebahat Şişman, Zeynep Saliha Güneş, Bilal Çakır, İbrahim Gülseren   +3 more
wiley   +1 more source