Results 181 to 190 of about 21,178 (234)

The Insulinotropic Action of Gastric Inhibitory Polypeptide

Canadian Journal of Physiology and Pharmacology, 1975
The effect of highly purified gastric inhibitory polypeptide (GIP) on immunoreactive insulin (IRI) secretion in the conscious fasted dog was investigated. Significant increases in IRI release were observed with intravenous administration of three different doses of GIP. These were accompanied by depression in fasting serum-glucose levels.
R A, Pederson, H E, Schubert, J C, Brown
openaire   +2 more sources

Immunoreactive Gastric Inhibitory Polypeptide*

Endocrine Reviews, 1988
IN 1906 extracts of mucosa from the upper small intestine from pigs were tested as a treatment of diabetes in the hope that “the internal secretion of the pancreas might be stimulated and initiated by the substance of the nature of a hormone yielded by the duodenal mucous membrane” (1).
openaire   +2 more sources

Identification and Actions of Gastric Inhibitory Polypeptide

1975
Publisher Summary This chapter gives an overview of the identification and actions of gastric inhibitory polypeptide (GIP). It describes an experiment in which it is concluded that exogenous or endogenous GIP is capable of insulinotropic effects in normal man and can lead to substantial acceleration of the disposal of glucose.
J C, Brown, J R, Dryburgh, S A, Ross, J, Dupré   +3 more
openaire   +2 more sources

The Hepatic Extraction of Gastric Inhibitory Polypeptide and Insulin*

Endocrinology, 1984
The hepatic extractions of gastric inhibitory polypeptide (GIP) and insulin were determined using in vitro and in vivo methods to assess the role of the liver in GIP metabolism and the possible effect of GIP on the hepatic extraction of insulin. During in vitro studies using the isolated perfused rat liver, infusion of GIP (2000 pg/ml) alone and in ...
J B, Hanks, D K, Andersen, J E, Wise, W S, Putnam, W C, Meyers, R S, Jones   +5 more
openaire   +2 more sources

Gastric Inhibitory Polypeptide (GIP)

1988
Publisher Summary This chapter describes two apparently unrelated physiological phenomena for a single peptide that is gastric inhibitory polypeptide (GIP). These physiological actions are the inhibition of gastric acid secretion and stimulation of insulin release. GIP is a major hormone involved in the gastrointestinal regulation of insulin release,
J.C. Brown, C.H.S. McIntosh, R.A. Pederson   +2 more
openaire   +1 more source

A RADIOIMMUNOASSAY OF GASTRIC INHIBITORY POLYPEPTIDE IN HUMAN PLASMA

Journal of Endocrinology, 1980
A sensitive radioimmunoassay for the measurement of human gastric inhibitory polypeptide (GIP), using pure porcine GIP, has been developed. Cross-reactivity of the antiserum with all available mammalian gut peptide preparations was negligible with the exception of glucagon when it was approximately 1%.
D L, Sarson, M G, Bryant, S R, Bloom
openaire   +2 more sources

Cholecystokinin and gastric inhibitory polypeptide not glucagonotropic in dogs

Journal of Surgical Research, 1980
Abstract The role of cholecystokinin (CCK) and gastric inhibitory polypeptide (GIP) as stimulators of glucagon secretion under physiologic conditions is uncertain. Previous studies have utilized CCK preparations now known to have been contaminated with GIP and possibly other gastrointestinal peptides.
K R, Sirinek, B A, Levine, S E, Crockett, S, Cataland   +3 more
openaire   +2 more sources

Determinants of gastric inhibitory polypeptide and insulin secretion

Metabolism, 1981
The plasma concentrations of gastric inhibitory polypeptide (IR-GIP), insulin, and glucose were measured in 5 dogs after administration of various constituents of food. IR-GIP responses produced by galactose and fructose were minimal compared to those of glucose.
R H, Williams, J M, May, J B, Biesbroeck
openaire   +2 more sources

Gastric Inhibitory Polypeptide: the neglected incretin revisited

Regulatory Peptides, 2002
After the ingestion of fat- and glucose-rich meals, gut hormones are secreted into the circulation in order to stimulate insulin secretion. This so-called "incretin effect" is primarily conferred by Glucagon-like peptide 1 (GLP-1) and Gastric Inhibitory Polypeptide (GIP).
Juris J, Meier, Michael A, Nauck, Wolfgang E, Schmidt, Baptist, Gallwitz   +3 more
openaire   +2 more sources

Gastric Inhibitory Polypeptide

Archives of Surgery, 1974
Gastric inhibitory polypeptide (GIP), immunoreactive insulin (IRI), and glucose levels in response to orally administered glucose were determined in ten patients with vagotomy and pyloroplasty (V&P) and in 21 normal subjects. The V&P patients had the expected early and exaggerated increase in mean serum glucose with a subsequent decline to a level ...
N R, Thomford, K R, Sirinek, S E, Crockett, E L, Mazzaferri, S, Cataland   +4 more
openaire   +2 more sources