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The Insulinotropic Action of Gastric Inhibitory Polypeptide
The effect of highly purified gastric inhibitory polypeptide (GIP) on immunoreactive insulin (IRI) secretion in the conscious fasted dog was investigated. Significant increases in IRI release were observed with intravenous administration of three different doses of GIP. These were accompanied by depression in fasting serum-glucose levels.
R A, Pederson, H E, Schubert, J C, Brown
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Identification and Actions of Gastric Inhibitory Polypeptide
Recent Progress in Hormone Research, 1975Publisher Summary This chapter gives an overview of the identification and actions of gastric inhibitory polypeptide (GIP). It describes an experiment in which it is concluded that exogenous or endogenous GIP is capable of insulinotropic effects in normal man and can lead to substantial acceleration of the disposal of glucose.
J C, Brown +3 more
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Glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide
Best Practice and Research in Clinical Endocrinology and Metabolism, 2004The 42 amino acid polypeptide glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide (GIP) is released from intestinal K-cells in response to nutrient ingestion. Based on animal studies, the peptide was initially assumed to act as an endogenous inhibitor of gastric acid secretion.
Juris J Meier, Michael A Nauck
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Gastric inhibitory polypeptide does not inhibit gastric emptying in humans
The insulinotropic gut hormone gastric inhibitory polypeptide (GIP) has been demonstrated to inhibit gastric acid secretion and was proposed to possess “enterogastrone” activity. GIP effects on gastric emptying have not yet been studied. Fifteen healthy male volunteers (23.9 ± 3.3 yr, body mass index 23.7 ± 2.3 kg/m2) were studied with the intravenous
Meier, Juris J +7 more
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Pharmacological Actions of Glucagon-Like Peptide-1, Gastric Inhibitory Polypeptide, and Glucagon. [PDF]
Glucagon family of peptide hormones is a group of structurally related brain-gut peptides that exert their pleiotropic actions through interactions with unique members of class B1 G protein–coupled receptors (GPCRs).
Revathi Sekar +3 more
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Inhibition of gastric inhibitory polypeptide signaling prevents obesity
Udgivelsesdato: 2002-JulSecretion of gastric inhibitory polypeptide (GIP), a duodenal hormone, is primarily induced by absorption of ingested fat. Here we describe a novel pathway of obesity promotion via GIP. Wild-type mice fed a high-fat diet exhibited
K. Miyawaki +20 more
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