Results 61 to 70 of about 722,266 (358)

Albendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release [PDF]

, 2014
The rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble com-pounds. Two possibilities for improving the dissolution of these drugs are to increase the available surface area and to im-prove their
Allemandi, Daniel Alberto, Castro, Silvina Gabriela, González Vidal, Noelia Luján, Palma, Santiago Daniel, Sanchez Bruni, Sergio Fabian   +4 more
core   +1 more source

Effects of ALDH2 Genotype, PPI Treatment and L-Cysteine on Carcinogenic Acetaldehyde in Gastric Juice and Saliva after Intragastric Alcohol Administration

PLoS ONE, 2015
Acetaldehyde (ACH) associated with alcoholic beverages is Group 1 carcinogen to humans (IARC/WHO). Aldehyde dehydrogenase (ALDH2), a major ACH eliminating enzyme, is genetically deficient in 30–50% of Eastern Asians. In alcohol drinkers, ALDH2-deficiency
R. Maejima, K. Iijima, P. Kaihovaara, W. Hatta, T. Koike, A. Imatani, T. Shimosegawa, M. Salaspuro   +7 more
semanticscholar   +1 more source

Wirelessly Powered Soft Magnetic Robot with Microneedle for Electrical Stimulation and Drug Delivery

Advanced Intelligent Systems, EarlyView.
A wirelessly powered soft magnetic robot integrates microneedles to enable dual functions: electrical stimulation (86.7% efficiency at 6 cm, tunable 0–20 V voltage, 0.4–50 ms pulses) and drug delivery. It switches surfaces via magnetic fields for gastrointestinal tract locomotion and treatment, with in vitro validation in fresh pig gut showing ...
Song Zhao, Liwen Zhang, Shengbin Zhang, Botao Ma, Meng Wang, Yipan Zuo, Xinzhao Zhou, Xueshan Jing, Huawei Chen   +8 more
wiley   +1 more source

Distinct microbial signatures of liquid biopsy samples during gastric carcinogenesis and insights from extracellular vesicle analysis [PDF]

The Korean Journal of Internal Medicine
Background/Aims The early detection of gastric cancer is crucial for improving patient outcomes. However, its pathogenesis is not fully understood. The microbiome and extracellular vesicles (EVs) might play a role in gastric carcinogenesis.
Hee Sang You, Jae Yong Park, Hochan Seo, Beom Jin Kim, Jae Gyu Kim   +4 more
doaj   +1 more source

Differential Proteomic Analysis of Human Saliva using Tandem Mass Tags Quantification for Gastric Cancer Detection. [PDF]

, 2016
Novel biomarkers and non-invasive diagnostic methods are urgently needed for the screening of gastric cancer to reduce its high mortality. We employed quantitative proteomics approach to develop discriminatory biomarker signatures from human saliva for ...
Cao, Cheng-Xi, Fan, Liu-Yin, Kim, Jae Joon, Kim, Kyoung Mee, Kim, Sung, Kim, Yong, Wong, David TW, Xiao, Hua, Yoshizawa, Janice, Zhang, Yan   +9 more
core   +2 more sources

Radium Speciation in Simulated Digestive Biofluids: Insights from Electrospray Ionization Mass Spectrometry and Thermodynamic Modeling

Analysis &Sensing, EarlyView.
Electrospray ionization mass spectrometry (ESI‐MS) combined with thermodynamic modeling provides the first direct characterization of radium speciation in synthetic gastrointestinal biofluids. Free Ra2+ ions predominate with minimal protein binding and negligible EDTA complexation. Crown ethers enable effective Ra complexation.
Linus Holtmann, Tim Schmalz, Tobias Weissenborn, Felix Stäger, Beate Riebe, Clemens Walther   +5 more
wiley   +1 more source

Microbial Diversity and Composition in Six Different Gastrointestinal Sites among Participants Undergoing Upper Gastrointestinal Endoscopy in Henan, China

Microbiology Spectrum, 2022
The objective of this study was to describe and compare the dynamic microbiota characteristics in the gastrointestinal (GI) tract in Chinese participants via high-throughput sequencing techniques.
Minjuan Li, Dantong Shao, Jiachen Zhou, Jianhua Gu, Junjie Qin, Xinqing Li, Changqing Hao, Wenqiang Wei   +7 more
doaj   +1 more source

In vitro screening of probiotic lactic acid bacteria and prebiotic glucooligosaccharides to select effective synbiotics [PDF]

, 2010
Probiotics and prebiotics have been demonstrated to positively modulate the intestinal microflora and could promote host health. Although some studies have been performed on combinations of probiotics and prebiotics, constituting synbiotics, results on ...
Courtin, Céline, Durand, Henri, Grimoud, Julien, Monsan, Pierre, Ouarné, Françoise, Roques, Christine, Theodorou, Vassilia   +6 more
core   +2 more sources

Effects of simulated gastric juice on color stability, surface roughness and microhardness of laboratory-processed composites.

Dental materials journal, 2014
Medical problems such as gastroesophageal reflux disease can cause considerable damage to restorations in the oral environment. This study evaluated the effects of gastric juice on the surface characteristics of different types of laboratory-processed ...
S. Cengiz, Şinasi Saraç, M. Özcan
semanticscholar   +1 more source

Fibers as Oleogelators: Innovations, Applications, and Future Prospects in Structured Lipid Systems

Journal of the American Oil Chemists' Society, EarlyView.
Schematic overview of fiber‐based oleogelation mechanisms, processing routes, and food applications highlighting particulate/capillary structuring, polymer entanglement, and emulsion‐templated approaches. ABSTRACT Oleogels, structured oil systems created with low levels of gelators‐enables solid fat functionality while preserving the underlying liquid ...
P. Abdul Wahid, Rajni Chopra, Nitin Kumar, Monika Chand, Aishwarya Dhiman, Rajat Singh   +5 more
wiley   +1 more source