Results 91 to 100 of about 236 (109)

The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice

European Journal of Pharmacology, 2004
The stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W.1419), which was promising in inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) trials, protects against both acute and chronic alcohol-induced lesions in stomach and liver, but also, given peripherally, affects various centrally mediated disturbances.
Predrag Sikiric, Alenka Boban Blagaic
exaly   +4 more sources

Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats

European Journal of Pharmacology, 2011
Chronic ibuprofen (0.4 g/kg intraperitoneally, once daily for 4 weeks) evidenced a series of pathologies, not previously reported in ibuprofen-dosed rats, namely hepatic encephalopathy, gastric lesions, hepatomegaly, increased AST and ALT serum values with prolonged sedation/unconsciousness, and weight loss.
Sven Seiwerth, Predrag Sikiric, Božo Radic   +2 more
exaly   +4 more sources

Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat

Surgery Today, 2008
Stable gastric pentadecapeptide BPC 157 accelerates the healing of a transected Achilles tendon and a transected quadriceps muscle. It may also be of clinical relevance as a systemic and local peptide treatment for crush injury of a major muscle, such as gastrocnemius muscle complex.
Novinšćak, Tomislav, Brčić, Luka, Starešinić, Mario, Jukić, Ivana, Radić, Božo, Pevec, Damira, Miše, Sandro, Tomasović, Sanja, Brčić, Iva, Banić, Tihomir, Jakir, Ana, Buljat, Gojko, Anić, Tomislav, Zoričić , Ivan, Romić, Željko, Seiwerth, Sven, Sikirić, Predrag   +16 more
openaire   +3 more sources

Stable gastric pentadecapeptide BPC 157 in the therapy of the rats with bile duct ligation

European Journal of Pharmacology, 2019
Recently, stable gastric pentadecapeptide BPC 157 reversed the high MDA- and NO-tissue values to the healthy levels. Thereby, BPC 157 therapy cured rats with bile duct ligation (BDL) (sacrifice at 2, 4, 6, 8 week). BPC 157-medication (10 μg/kg, 10 ng/kg) was continuously in drinking water (0.16 μg/ml, 0.16 ng/ml, 12 ml/rat/day) since awakening from ...
Zenko Sever, Anita, Sever, Marko, Vidović, Tinka, Lojo, Nermin, Kolenc, Danijela, Batelja Vuletić, Lovorka, Drmić, Domagoj, Kokot, Antonio, Zoričić, Ivan, Ćorić, Marijana, Vlainić, Josipa, Poljak, Ljiljana, Seiwerth, Sven, Sikirić, Predrag   +13 more
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Gastric pentadecapeptide BPC 157 counteracts morphine-induced analgesia in mice.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2009
Previously, the gastric pentadecapeptide BPC 157, (PL 14736, Pliva) has been shown to have several beneficial effects, it exert gastroprotective, anti-inflammatory actions, stimulates would healing and has therapeutic value in inflammatory bowel disease.
Boban Blagaić, Alenka, Turčić, Petra, Blagaić, Vladimir, Dubovečak, Miroslav, Jelovac, Nikola, Zemba, Mladen, Radić, Božo, Bečejac, Tomislav, Stančić-Rokotov, Dinko, Sikirić, Predrag   +9 more
openaire   +2 more sources

Pentadecapeptide BPC 157 attenuates gastric lesions induced by alloxan in rats and mice

Journal of Physiology-Paris, 1999
A diabetogenic alloxan regimen produced lesions in all stomachs of treated animals, either rats (200 mg x kg(-1) s.c.) or mice (400 mg x kg(-1) i.p.). In control animals, the lesions, when developed (i.e. 24 h following application), appear to be quite sustained, and consistently present also after 1 or 2 weeks.
Petek, Marijan, Sikirić, Predrag, Anić, Tomislav, Buljat, Gojko, Šeparović, Jadranka, Stančić-Rokotov, Dinko, Seiwerth, Sven, Grabarević, Željko, Ručman, Rudolf, Mikuš, Darko, Zoričić, Ivan, Prkačin, Ingrid, Šebečić, Božidra, Žiger, T., Čorić, Velimir, Turković, Branko, Aralica, Gorana, Rotkvić, Ivo, Miše, Stjepan, Hahn, V.   +19 more
openaire   +3 more sources

Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157

Current pharmaceutical design, 2013
Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, proven in clinical trials to be both safe in inflammatory bowel disease (PL-10, PLD-116, PL 14736) and wound healing, stable in human gastric juice, with no toxicity being reported. Recently, we claim that BPC 157 may be used as an antidote against NSAIDs. We focused on BPC 157
Šebečić, Božidar, Sever, Marko, Vrčić, Hrvoje, Stančić-Rokotov, Dinko, Kliček, Robert, Seiwerth, Sven, Turković, Branko, Aralica, Gorana, Šuran, Jelena, Džidić, Senka, Safić Stanić, Hana, Rak, Davor, Ilić, Spomenko, Brčić, Luka, Kolenc, Danijela, Sikirić, Predrag   +15 more
openaire   +1 more source

Stable Gastric Pentadecapeptide BPC 157 as a Therapy of Severe Electrolyte Disturbances in Rats

Current Neuropharmacology
This review explores the therapeutic potential of the stable gastric pentadecapeptide BPC 157 in addressing electrolyte imbalances, specifically hyperkalemia, hypokalemia, hypermagnesemia, and hyperlithiemia.
Marija Medvidovic, Grubisic, Sanja, Strbe, Ivan, Barisic, Dijana, Balenovic, Vasilije, Stambolija, Marin, Lozic, Sanja Barsic, Ostojic, Ivana, Oreskovic, Helena, Zizek, Klara, Brcic, Luka, Coric, Mario, Staresinic, Vladimir, Blagaic, Lidija Beketic, Oreskovic, Zeljka Belosic, Halle, Danijel, Matek, Dragan, Soldo, Boris, Grizelj, Alenka Boban, Blagaic, Anita, Skrtic, Sven, Seiwerth, Predrag, Sikiric   +21 more
openaire   +2 more sources

Beneficial effects of gastric pentadecapeptide BPC 157 on sciatic nerve regeneration.

Digestive diseases and sciences, 2003
Beneficial effects of gastric pentadecapeptide BPC 157 on sciatic nerve regeneration.
Gjurašin, Mirko, Miklić, Pavle, Perović, Darko, Jukić, Ivana, Sikirić, Predrag, Kokić, Neven, Seiwerth, Sven, Žarković, Kamelija   +7 more
openaire   +1 more source

Stable gastric pentadecapeptide BPC-157 heals transected muscle in rat.

Digestive diseases and sciences, 2003
Stable gastric pentadecapeptide BPC-157 heals transected muscle in rat.
Starešinić, Mario, Jukić, Ivana, Kokić, Neven, Petrović, Igor, Drviš, Petar, Kopljar, Mario, Boban Blagaić, Alenka, Krivić, Andrija, Batelja Vuletić, Lovorka, Sikirić, Predrag, Dobrić, Ivan   +10 more
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