Results 81 to 90 of about 236 (109)

Focus on Ulcerative Colitis: Stable Gastric Pentadecapeptide BPC 157

Current Medicinal Chemistry, 2012
Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects. BPC 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD) (PL 14736) so far only tested in clinical phase II, has a ...
P, Sikiric, S, Seiwerth, R, Rucman, B, Turkovic, D S, Rokotov, L, Brcic, M, Sever, R, Klicek, B, Radic, D, Drmic, S, Ilic, D, Kolenc, V, Stambolija, Z, Zoricic, H, Vrcic, B, Sebecic   +15 more
  +5 more sources

Gastric pentadecapeptide BPC 157 effective against serotonin syndrome in rats [PDF]

European Journal of Pharmacology, 2005
Serotonin syndrome commonly follows irreversible monoamine oxidase (MAO)-inhibition and subsequent serotonin (5-HT) substrate (in rats with fore paw treading, hind limbs abduction, wet dog shake, hypothermia followed by hyperthermia). A stable gastric pentadecapeptide BPC 157 with very safe profile (inflammatory bowel disease clinical phase II, PL-10 ...
Predrag Sikiric, Mario Starešinič, Tomislav Anic   +2 more
exaly   +3 more sources

Stable gastric pentadecapeptide BPC 157 and bupivacaine

European Journal of Pharmacology, 2016
Bupivacaine toxicity following accidental overdose still lacks therapeutic solution. However, there are major arguments for testing BPC 157 against bupivacaine toxicity in vivo in rats, in particular, and then finally, in vitro. These are: the lack of any known BPC 157 toxicity, a lifesaving effect via the mitigation of arrhythmias in rats underwent ...
Živanović-Posilović, Gordana, Balenović, Diana, Barišić, Ivan, Strinić, Dean, Stambolija, Vasilije, Udovičić, Mario, Uzun, Sandra, Drmić, Domagoj, Vlainić, Josipa, Lovrić Benčić, Martina, Sindić, Aleksandra, Seiwerth, Sven, Sikirić, Predrag   +12 more
openaire   +3 more sources

Toxicity by NSAIDs. Counteraction by Stable Gastric Pentadecapeptide BPC 157

Current Pharmaceutical Design, 2012
Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, proven in clinical trials to be both safe in inflammatory bowel disease (PL-10, PLD-116, PL 14736) and wound healing, stable in human gastric juice, with no toxicity being reported. Recently, we claim that BPC 157 may be used as an antidote against NSAIDs. We focused on BPC 157
Sikirić, Predrag, Seiwerth, Sven, Ručman, Rudolf, Turković, Branko, Stančić-Rokotov, Dinko, Brčić, Luka, Sever, Marko, Kliček, Robert, Radić, Božo, Drmić, Domagoj, Ilić, Spomenko, Kolenc, Danijela, Aralica, Gorana, Safić, Hana, Šuran, Jelena, Rak, Davor, Džidić, Senka, Vrčić, Hrvoje, Sebečić, Božidar   +18 more
openaire   +3 more sources

Stable Gastric Pentadecapeptide BPC 157-NO-system Relation

Current Pharmaceutical Design, 2014
We reviewed stable gastric pentadecapeptide BPC 157-NO-system-relation, its close participation in Moncada's (maintained vascular integrity, platelets control) homeostatic healing response of NO-system to injury. Namely, BPC 157's particular healing effect also affects all events after vascular integrity loss (dependent on circumstances, it reduces ...
Sikirić, Predrag, Seiwerth, Sven, Ručman, Rudolf, Turković, Branko, Stančić - Rokotov, Dinko, Brčić, Luka, Sever, Marko, Kliček, Robert, Radić, Božo, Drmić, Domagoj, Ilić, Spomenko, Kolenc, Danijela, Aralica, Gorana, Stupnišek, Marijana, Šuran, Jelena, Barišić, Ivan, Džidić, Senka, Vrčić, Hrvoje, Šebečić, Božidar   +18 more
openaire   +4 more sources

Corticosteroid-impairment of healing and gastric pentadecapeptide BPC-157 creams in burned mice

Burns, 2003
The amelioration of corticosteroid-impairment of healing by a stable gastric pentadecapeptide BPC-157 (GEPPPGKPADDAGLV, M(w) 1419, currently in early clinical trials for inflammatory bowel disease) was studied in thermally injured mice. Its effects on corticosteroid impaired healing of deep partial skin thickness burns, and burn-gastric lesions were ...
Neven Zarkovic, Predrag Sikiric, Miroslav Gjurašin   +2 more
exaly   +4 more sources

Gastric Pentadecapeptide BPC 157 and Short Bowel Syndrome in Rats

Digestive Diseases and Sciences, 2008
The gastric pentadecapeptide BPC 157, which was shown to be safe as an antiulcer peptide in trials for inflammatory bowel disease (PL14736, Pliva), successfully healed intestinal anastomosis and fistula in rat. Therefore, we studied for 4 weeks rats with escalating short bowel syndrome and progressive weight loss after small bowel resection from fourth
Sever, Marko, Kliček, Robert, Radić, Božo, Brčić, Luka, Zoričić, Ivan, Drmić, Domagoj, Ivica, Mihovil, Barišić, Ivan, Ilić, Spomenko, Berkopić, Lidija, Boban Blagaić, Alenka, Ćorić, Marijana, Kolenc, Danijela, Vrčić, Hrvoje, Anić, Tomislav, Seiwerth, Sven, Sikirić, Predrag   +16 more
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Stable gastric pentadecapeptide BPC 157 heals rat colovesical fistula

European Journal of Pharmacology, 2016
To establish the effects of BPC 157 on the healing of rat colovesical fistulas, Wistar Albino male rats were randomly assigned to different groups. BPC 157, a stable gastric pentadecapeptide, has been used in clinical applications-specifically, in ulcerative colitis-and was successful in treating both external and internal fistulas.
Grgić, Tihomir, Grgić, Dora, Drmić, Domagoj, Zenko Sever, Anita, Petrović, Igor, Sučić, Mario, Kokot, Antonio, Kliček, Robert, Sever, Marko, Seiwerth, Sven, Sikirić, Predrag   +10 more
openaire   +2 more sources

Stable gastric pentadecapeptide BPC 157 heals rectovaginal fistula in rats

Life Sciences, 2016
Rectovaginal fistula is a devastating condition providing more than 99% of patients for surgical treatment. We hypothesized that rectovaginal fistula may be healed by therapy with stable gastric pentadecapeptide BPC 157, in consistence with its initial clinical application and effect on external fistulas.BPC 157 (10μg/kg or 10ng/kg) was given perorally,
Barić, Marko, Zenko Sever, Anita, Batelja Vuletić, Lovorka, Rašić, Žarko, Sever, Marko, Drmić, Domagoj, Pavelić-Turudić, Tatjana, Sučić, Mario, Vrčić, Hrvoje, Seiwerth, Sven, Sikirić, Predrag   +10 more
openaire   +3 more sources

Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157

Journal of Orthopaedic Research, 2006
AbstractWe report complete transection of major muscle and the systemic peptide treatment that induces healing of quadriceps muscle promptly and then maintains the healing with functional restoration. Initially, stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419, PL‐10, PLD‐116, PL 14736 Pliva, Croatia; in trials for inflammatory bowel
Starešinić, Mario, Petrović, Igor, Novinšćak, Tomislav, Jukić, Ivana, Pevec, Damira, Suknaić, Slaven, Kokić, Neven, Batelja, Lovorka, Brčić, Luka, Boban-Blagaić, Alenka, Zorić, Zdenka, Ivanović, Domagoj, Ajduk, Marko, Sebečić, Božidar, Patrlj, Leonardo, Soša, Tomislav, Buljat, Gojko, Anić, Tomislav, Seiwerth, Sven, Sikirić, Predrag   +19 more
openaire   +2 more sources