Results 61 to 70 of about 55,603 (271)
ChemMedChem, Accepted Article.The cannabinoid receptor type 2 (CB2R) is overexpressed under pathological conditions. PET is a suitable non‐invasive imaging technique for diagnosing disease states, but requires a radiotracer that binds to CB2R with high affinity and selectivity. Currently, there is no suitable candidate routinely used in the clinics.
Lea Ueberham +4 more
wiley +1 more source
Recent advances on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangiocyte pathophysiology [PDF]
, 2013 Cholangiocytes are epithelial cells lining the biliary epithelium. Cholangiocytes play several key roles in the modification of ductal bile and are also the target cells in chronic cholestatic liver diseases (i.e., cholangiopathies) such as PSC, PBC ...
Alvaro, Domenico +6 more
core +1 more source
Effect of GRK4 on renal gastrin receptor regulation in hypertension
Clinical and Experimental Hypertension, 2023 Objective To investigate whether GRK4 regulates the phosphorylation and function of renal CCKBR. Methods GRK4 A142V transgenic mice were used as an animal model of enhanced GRK4 activity, and siRNA was used to silence the GRK4 gene to investigate the ...
Xuewei Xia +9 more
doaj +1 more source
Gastrin-17 Levels in Pre-malignancy Gastritis Lesions
European Medical Journal Gastroenterology, 2022 Background: Gastritis is an inflammatory process on the lining of the stomach that could be caused by various factors. Untreated inflammatory processes could lead to ulcers. Gastrin hormone is released by gastrin-secreting enteroendocrine cells (G cells)
Sahat Halim, Gontar Alamnsyah Siregar
doaj +1 more source
Benzochalcogenodiazoles, Synthesis, and Applications in Medicinal Chemistry and Photomedicine
European Journal of Organic Chemistry, EarlyView.Benzochalcogenodiazoles (BXD) including benzoxadiazoles, benzothiadiazoles, and benzoselenadiazoles are initially mainly designed for optoelectronic materials as electron‐deficient cores. Nevertheless, they are now extending their application to biology.
Jean‐Elie Zheng +2 more
wiley +1 more source
Vagal Blocking for Obesity Control : a Possible Mechanism-Of-Action [PDF]
, 2017 14 September 2016 Erratum to: Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action Helene Johannessen, David Revesz, Yosuke Kodama, Nikki Cassie, Karolina P Skibicka, Perry Barrett, Suzanne Dickson, Jens Holst, Jens Rehfeld, Geoffrey van ...
Adan, Roger +14 more
core +1 more source
Complete tyrosine O-sulfation of gastrin in adult and neonatal cat pancreas [PDF]
, 1986 We have found gastrin in both the adult and neonatal cat pancreas. In contrast with the main production sites, antrum and duodenum, gastrin in the pancreas occurs in a single molecular form, tyrosine O-sulfated gastrin-17.
Andersen, B.N. +2 more
core +1 more source
The Development and Challenges of PET/MRI Dual‐Modality Imaging Probes—An Update
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT The integration of Positron emission tomography (PET) with Magnetic resonance imaging (MRI) combines the functional imaging capabilities of PET with the high‐resolution anatomical detail of MRI, creating a synergistic platform for advanced diagnostic imaging and image‐guided therapies. Central to the success of this dual‐modality system is the
Maryam Sabbaghan +5 more
wiley +1 more source
The Interplay between Hormones and Irritable Bowel Disease [PDF]
, 2013 Thesis (M.A.)--Boston UniversityThis thesis examines the underlying mechanisms causing the severe and often debilitating symptoms associated with both Irritable Bowel Syndrome and Inflammatory Bowel Disease.
Linson, Elyse A.
core +1 more source
Distinct roles of NMB and GRP in itch transmission [PDF]
, 2017 A key question in our understanding of itch coding mechanisms is whether itch is relayed by dedicated molecular and neuronal pathways. Previous studies suggested that gastrin-releasing peptide (GRP) is an itch-specific neurotransmitter. Neuromedin B (NMB)
Bardoni, Rita +16 more
core +3 more sources