Results 71 to 80 of about 29,877 (187)

Real‐World Prognostic Analysis of Clinical Characteristics in Extensive‐Stage Small Cell Lung Cancer: A Nomogram for Survival Prediction in Patients Receiving First‐Line Immunochemotherapy With Serplulimab

Cancer Medicine, Volume 15, Issue 8, August 2026.
Among 239 patients reviewed, 109 patients with extensive‐stage small‐cell lung cancer receiving first‐line serplulimab‐based immunochemotherapy were included. A nomogram incorporating liver metastasis, maintenance therapy, albumin, and neutrophil‐to‐lymphocyte ratio predicted overall survival and significantly stratified patients into three risk groups
Ying Zhu, Zhongwen Li, Ming Zhang, Yuyun Lan, Yarong Wang, Yao Liu, Yibing Liu   +6 more
wiley   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Efficacy and Tolerability of Tegoprazan Compared to Proton Pump Inhibitors in the Treatment of Erosive Esophagitis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

JGH Open, Volume 10, Issue 8, August 2026.
ABSTRACT Aim Tegoprazan, a potassium‐competitive acid blocker, is an acid‐suppressing medication under review as a potential alternative treatment in cases of erosive esophagitis. This systematic review and meta‐analysis assesses the efficacy and tolerability of tegoprazan compared to proton pump inhibitors, the current standard of care. Methods Pubmed,
Youssef Diab, Charbel Maalouf, Anthony Junior Al Hakim, Perla Chami, Ali Ghais, Etwal Bou Raad, Louis Chaptini   +6 more
wiley   +1 more source

Influence of Proton Pump Inhibitor Use in Gastrointestinal Polyps

Kaohsiung Journal of Medical Sciences, 2010
Proton pump inhibitors (PPIs) are the most potent anti-acid agents and are extensively used worldwide. PPI-induced hypergastrinemia is one of the very few side effects associated with these drugs.
Wen-Hung Hsu, I-Chen Wu, Chao-Hung Kuo, Yu-Chung Su, Chien-Yu Lu, Fu-Chen Kuo, Chang-Ming Jan, Wen-Ming Wang, Deng-Chyang Wu, Fang-Jung Yu   +9 more
doaj   +1 more source

Small Cell Lung Cancer Associated With Cystic Airspace: A Case Report and Literature Review

Respirology Case Reports, Volume 14, Issue 8, August 2026.
We report a rare case of small cell lung cancer (SCLC) associated with a cystic airspace. Chest CT revealed a solid tumour component arising from the wall of a pre‐existing lung cyst. This case highlights the clinical importance of recognising cystic airspaces as potential sites for aggressive malignancies like SCLC.
Hiroyuki Shimada, Yukihisa Inoue, Osamu Matsubara, Mio Yamamoto, Shohei Yamashita, Tetsu Hara, Kazuki Yamanaka, Yasuto Jinn   +7 more
wiley   +1 more source

Proteomic and metabolic signatures of female reproductive factors and risk of age‐related ocular diseases: A large prospective cohort study

VIEW, Volume 7, Issue 4, August 2026.
The full editable vector source file of this graphical abstract is uploaded as a supplementary EPS file for typesetting. All elements are copyright‐free. Abstract Age‐related ocular diseases (ARODs), including cataract, primary open‐angle glaucoma (POAG), and age‐related macular degeneration (AMD), are leading causes of vision impairment and exhibit ...
Linge Jian, Zhiqian Huang, Keke Zhang, Jing Lin, Jia You, Yi Lu, Xiangjia Zhu   +6 more
wiley   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Effect of Chewing Gum on Bowel Function Recovery in Elderly Patients Following Posterior Lumbar Fusion Surgery: A Randomized Controlled Trial

Orthopaedic Surgery, Volume 18, Issue 8, Page 1641-1648, August 2026.
Chewing gum did not improve early bowel recovery after lumbar fusion. ABSTRACT Objective Given the paucity of prospective randomized evidence on chewing gum for postoperative bowel recovery in elderly spinal fusion patients, this study aimed to assess the efficacy of chewing gum in improving bowel function recovery in the elderly after posterior lumbar
Fuze Liu, Yifei Li, Gaoyang Li, Xiaoyan He, Lin Zhang, Meijia Zhang, Tian Liu, Ying Jiang, Qinlu Wang, Yaping Chen, Hai Wang   +10 more
wiley   +1 more source

Serum gastrin concentrations in dogs with primary hyperparathyroidism

Journal of Veterinary Internal Medicine
Background Hypercalcemia has been associated with hypergastrinemia in humans. Hypergastrinemia could be responsible for gastrointestinal (GI) signs in dogs with primary hyperparathyroidism (PHPT).
Julieann Vose, Jared Jaffey, Camille Akin, Alexander Spitzer, Barry DeCicco, Enass Bassiouny, Ashley LaClair, Brian Petroff, Jean Brudvig, Harry Cridge   +9 more
doaj   +1 more source

Gastric neuroendocrine neoplasms: analysis of a cohort of patients followed at the Brazilian National Cancer Institute

Endocrine Oncology
Objective: Gastric neuroendocrine neoplasms (G-NENs) are rare tumors categorized into subtypes, each exhibiting unique characteristics, levels of aggressiveness and prognostic implications.
Sarah Adelaide M Campos, Bruno Vilhena Pereira, Cibele Barbosa Carroll, Rinaldo Gonçalves, Reinaldo Rondinelli, Daniel Bulzico   +5 more
doaj   +1 more source