Results 61 to 70 of about 40,702 (217)

Highly improved metabolic stability and pharmacokinetics of indium-111-DOTA-gastrin conjugates for targeting of the gastrin receptor

, 2011
The development of metabolically stable radiolabeled gastrin analogues with suitable pharmacokinetics is a topic of recent research activity. These imaging vectors are of interest because the gastrin/CCK2 receptor is highly overexpressed in different ...
Tanja Gmeiner-Stopar, Baum, Richard Paul, Mansi, Rosalba, Reubi, Jean Claude, Tamma, MariaLuisa, Mäcke, Helmut R., Gmeiner-Stopar, Tanja, Tamma, Maria Luisa, Waser, Beatrice, MariaLuisa Tamma, Helmut R. Maecke, Maecke, Helmut R, Baum, Richard P, Reubi, Jean-Claude, Petra Kolenc-Peitl, Kolenc Peitl, Petra, Kolenc-Peitl, Petra, Rosalba Mansi, Sollner Dolenc, Marija, Beatrice Waser, Richard P. Baum, Marija Sollner-Dolenc, Sollner-Dolenc, Marija, Jean Claude Reubi   +23 more
core   +1 more source

Perioperative Risks of Concurrent Pancreatic and Hepatic Resections for Neuroendocrine Tumors

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Pancreatic neuroendocrine tumors (pNETs) account for 1%–2% of pancreatic tumors, with an increasing incidence. The safety of concurrent pancreas‐liver resections remains uncertain. This study evaluated the national outcomes of concurrent pancreatectomy and liver‐directed surgery for pNETs. Methods ACS‐NSQIP (2019–2023)
Amir Ebadinejad, Ashrita Raghuram, Sophia Xiao, Ethan Angle, Hassan Aziz   +4 more
wiley   +1 more source

Gastrin-17 Levels in Pre-malignancy Gastritis Lesions

European Medical Journal Gastroenterology, 2022
Background: Gastritis is an inflammatory process on the lining of the stomach that could be caused by various factors. Untreated inflammatory processes could lead to ulcers. Gastrin hormone is released by gastrin-secreting enteroendocrine cells (G cells)
Sahat Halim, Gontar Alamnsyah Siregar
doaj   +1 more source

Diagnostic value of plasma TFF3‐centered combined biomarker panel in early gastrointestinal cancer

VIEW, EarlyView.
In this study, a retrospective cohort was established, including gastrointestinal cancer, non‐GI cancer, and healthy controls. TFF3, CEA, and gastric function indicators were detected. TFF3 showed significantly better diagnostic performance compared with conventional gastrointestinal indicators in gastric cancer, and compared with CEA in ...
Yizhou Huang, Wenjia Guo, Xiaosi Hu, Zhangming Chen, Chen Chen, Aman Xu, Hongchen Gu, Hong Xu   +7 more
wiley   +1 more source

Antral G-cell in gastrin and gastrin-cholecystokinin knockout animals

, 2005
The antral hormone gastrin is the key regulator of gastric acid secretion, mucosal growth and differentiation. Gastrin is synthesized in the endocrine G-cells in the antroduodenal mucosa. We have now examined the way in which the loss of gastrin alone or
Wierup, Nils, Rehfeld, J F, Rehfeld, Jens F., Friis-Hansen, Lennart, Friis-Hansen, L, Wierup, Nils,, Sundler, Frank,, Lund University., Sundler, Frank   +8 more
core   +1 more source

The Search for Submammalian Gastrins: The Identification of Amphibian Gastrin

Experimental Biology and Medicine, 1976
SummaryExtracts of the digestive tracts of three amphibian species were examined by radioimmunoassay for gastrin-like materials. Gastrin was detected in all three species of amphibia examined. In R. cates-beiana and R. pipiens the largest tissue concentrations of gastrin were found in the antrum, followed by the duodenum and pancreas, respectively, in ...
R G, Gibson, A A, Mihas, H W, Colvin, B I, Hirschowitz   +3 more
openaire   +2 more sources

The TOP‐GERD Trial: Comparative Efficacy of Tegoprazan Versus Pantoprazole in the Treatment of Erosive Oesophagitis in a Non‐Asian Population

Alimentary Pharmacology &Therapeutics, EarlyView.
In this randomized, double‐blind trial in Mexican adults with erosive oesophagitis, tegoprazan did not significantly improve the primary 4‐week ITT healing endpoint versus pantoprazole (88.9% vs. 79.4%; p = 0.33), but produced faster symptom improvement. Encouraging per‐protocol and severe‐oesophagitis findings warrant confirmation.
José M. Remes‐Troche, Luis Raúl Valdovinos‐García, C. Prakash Gyawali, José Luis Vargas‐Basurto, Carlos Alberto Reyes‐Medina, Gisselle Vanessa González‐Hernández, A. Rafael Bernal Mendez, H. H. Barragán Cordova, Pablo Thomas‐Dupont, Peter Grube‐Pagola   +9 more
wiley   +1 more source

Premises for Cholecystokinin and Gastrin Peptides in Diabetes Therapy

Clinical Medicine Insights: Endocrinology and Diabetes, 2019
Gastrin and cholecystokinin (CCK) are classical gastrointestinal peptide hormones. Their biogenesis, structures, and intestinal secretory patterns are well-known with the striking feature that their receptor-bound ‘active sites’ are highly homologous and
Jens F Rehfeld
doaj   +1 more source

Gastrin inhibits gastric cancer progression through activating the ERK-P65-miR23a/27a/24 axis

Journal of Experimental & Clinical Cancer Research, 2018
Background To test the hypothesis that activated extracellular signal-regulated kinase (ERK) regulates P65-miR23a/27a/24 axis in gastric cancer (GC) and the ERK-P65-miR23a/27a/24 axis plays an important role in the development of GC, and to evaluate the ...
Li-Dong Zu, Xing-Chun Peng, Zhi Zeng, Jing-Long Wang, Li-Li Meng, Wei-Wei Shen, Chun-Ting Hu, Ye Yang, Guo-Hui Fu   +8 more
doaj   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source