Results 71 to 80 of about 55,603 (271)

Premises for Cholecystokinin and Gastrin Peptides in Diabetes Therapy

Clinical Medicine Insights: Endocrinology and Diabetes, 2019
Gastrin and cholecystokinin (CCK) are classical gastrointestinal peptide hormones. Their biogenesis, structures, and intestinal secretory patterns are well-known with the striking feature that their receptor-bound ‘active sites’ are highly homologous and
Jens F Rehfeld
doaj   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

Circulating gastrin is increased in hemochromatosis [PDF]

, 2006
Gastric acid production is important in intestinal iron absorption. The peptide hormone gastrin exists in both amidated and non-amidated forms, which stimulate and potentiate gastric acid secretion, respectively.
Anderson, Gregory J., Baldwin, Graham S., Kovac, Suzana, Shulkes, Arthur, Smith, Kelly A.   +4 more
core   +1 more source

Correlation between serum gastrin and cellular proliferation in Barrett’s esophagus

Therapeutic Advances in Gastroenterology, 2011
Background: Patients with Barrett’s esophagus (BE) are commonly treated with proton-pump inhibitors (PPIs) to minimize the exposure of esophageal mucosa to stomach acid.
Daniel A. Green, Carrie M. Mlynarczyk, Benjamin J. Vaccaro, Kristina M. Capiak, Michael Quante, Charles J. Lightdale, Julian A. Abrams   +6 more
doaj   +1 more source

Human Pulmonary Neuroendocrine Cells Respond to House Dust Mite Extract With PAR‐1 Dependent Release of CGRP

Allergy, Volume 80, Issue 4, Page 976-985, April 2025.
This study aimed to develop and characterize an in vitro human PNEC model and investigated the neuroendocrine response to HDM extract. Exposure to HDM leads to dose‐dependent induction of the CGRP encoding gene, CALCB, and corresponding release of the neuropeptide.
Ritu Mann‐Nüttel, Shivani Mandal, Marie Armbruster, Lakshmi Puttagunta, Paul Forsythe   +4 more
wiley   +1 more source

Predictors of Mortality in Patients With Multiple Endocrine Neoplasia Type 1

Clinical Endocrinology, EarlyView.
SUMMARY Objective Multiple Endocrine Neoplasia Type 1 (MEN 1) is an autosomal dominant disease predisposing to hyperplasia and neoplasia in diverse endocrine tissues. Patients typically present with endocrine abnormalities before the age of 30 years and have reduced life expectancy.
Jasmine J. Zhu, John R Burgess
wiley   +1 more source

Neurochemical characterization of pERK-expressing spinal neurons in histamine-induced itch [PDF]

, 2015
Date of Acceptance: 08/07/2015 Acknowledgements This work was supported by grants from the Ministry of Science and Technology of China (2012CB966904, 2011CB51005), National Natural Science Foundation of China (31271182, 81200692, 91232724, 81200933 ...
Chai, Guo-Dong, Chen, Jia-Yin, Chen, Ling, Dai, Meng-Han, Ding, Yu-Qiang, Huang, Kun, Jiang, Guan-Yu, Lang, Bing, McCaig, Colin, St Clair, David, Wang, Qing-Xiu, Zhang, Ling   +11 more
core   +1 more source

Serum Gastrin and Pepsinogen Levels after Administration of Acid Secretion Inhibitors for Ulcers due to Endoscopic Submucosal Dissection in Patients with Early Gastric Cancer

Gastroenterology Research and Practice, 2022
Acid secretion inhibitors, such as proton pump inhibitors (PPIs) and potassium competitive acid blockers (PCABs), are used to treat ulcers after endoscopic submucosal dissection (ESD) for early gastric cancer.
Maidina Abuduwaili, Tomoyuki Boda, Masanori Ito, Hidehiko Takigawa, Takahiro Kotachi, Taiji Matsuo, Shiro Oka, Shinji Tanaka   +7 more
doaj   +1 more source

Type 2 and type 3 gastric neuroendocrine tumors have high risk of lymph node metastasis: Systematic review and meta‐analysis

Digestive Endoscopy, EarlyView.
Objectives Lymph node metastasis (LNM) is crucial in determining treatment strategies for gastric neuroendocrine tumors (gNETs). While type 3 is considered more aggressive than types 1 and 2 within the clinical subtype of gNETs, the supporting data were insufficient, due to their rarity. We aimed to study the prevalence and risk factors associated with
Yohei Ogata, Waku Hatta, Takeshi Kanno, Masahiro Saito, Xiaoyi Jin, Naoki Asano, Tomoyuki Koike, Akira Imatani, Yuhong Yuan, Atsushi Masamune   +9 more
wiley   +1 more source

Gastrin inhibits gastric cancer progression through activating the ERK-P65-miR23a/27a/24 axis

Journal of Experimental & Clinical Cancer Research, 2018
Background To test the hypothesis that activated extracellular signal-regulated kinase (ERK) regulates P65-miR23a/27a/24 axis in gastric cancer (GC) and the ERK-P65-miR23a/27a/24 axis plays an important role in the development of GC, and to evaluate the ...
Li-Dong Zu, Xing-Chun Peng, Zhi Zeng, Jing-Long Wang, Li-Li Meng, Wei-Wei Shen, Chun-Ting Hu, Ye Yang, Guo-Hui Fu   +8 more
doaj   +1 more source