Results 1 to 10 of about 12,862 (225)
Progastrin Represses the Alternative Activation of Human Macrophages and Modulates Their Influence on Colon Cancer Epithelial Cells [PDF]
PLoS ONE, 2014 Macrophage infiltration is a negative prognostic factor for most cancers but gastrointestinal tumors seem to be an exception. The effect of macrophages on cancer progression depends on their phenotype, which may vary between M1 (pro-inflammatory ...
A Algars +41 more
core +5 more sources
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Gastrin, gastrin receptors and colorectal carcinoma [PDF]
Gut, 1998 The possibility that gastrin may play a role in the development of colorectal carcinoma has aroused considerable interest over the past decade. In early reports some colorectal carcinomas and colorectal carcinoma cell lines were shown to produce gastrin,1 to express gastrin receptors,2 and to respond mitogenically to exogenous gastrin.2 The most ...
G S Baldwin, A Shulkes
openaire +3 more sources
Circulating gastrin is increased in hemochromatosis [PDF]
, 2006 Gastric acid production is important in intestinal iron absorption. The peptide hormone gastrin exists in both amidated and non-amidated forms, which stimulate and potentiate gastric acid secretion, respectively.
Anderson, Gregory J. +4 more
core +1 more source
Complete tyrosine O-sulfation of gastrin in adult and neonatal cat pancreas [PDF]
, 1986 We have found gastrin in both the adult and neonatal cat pancreas. In contrast with the main production sites, antrum and duodenum, gastrin in the pancreas occurs in a single molecular form, tyrosine O-sulfated gastrin-17.
Andersen, B.N. +2 more
core +1 more source
Disturbed progastrin processing in carboxypeptidase E‐deficient fat mice [PDF]
, 1997 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116303/1/feb2s0014579397011642 ...
Arnold +29 more
core +1 more source
Acute effects of N-terminal progastrin fragments on gastric acid secretion in man [PDF]
, 2017 We previously identified an N‐terminal fragment of progastrin in human antrum and plasma, where it circulates in high concentrations. In this study, we examined the effects of N‐terminal progastrin fragments on gastric acid secretion by infusion in ...
Goetze, Jens P +2 more
core +1 more source
The Lancet, 1965 The Lancet 285 (1965) 816-816.
University of Florida, Gainesville, United States. ( host institution ) +1 more
openaire +3 more sources
Binding of progastrin fragments to the 78 kDa gastrin-binding protein [PDF]
, 1995 The non-selective gastrin/cholecystokinin receptor antagonists proglumide and benzotript inhibit colon carcinoma cell proliferation by binding to the 78 kDa gastrin-binding protein (GBP) (Baldwin, Proc. Natl. Acad. Sci. USA, 91 (1994) 7593–7597). However,
Baldwin, Graham S.
core +1 more source
Glycine-extended gastrin promotes the growth of lung cancer [PDF]
, 2004 The less processed forms of gastrin have recently been shown to act as trophic factors for both normal and malignant colonic cells. Although incompletely processed forms of gastrin such as glycine-extended gastrin and progastrin are also expressed in ...
Cui, Guanglin +8 more
core +2 more sources