Results 41 to 50 of about 35,918 (226)

Human Organoids and Their Application in Tumor Models, Disease Modeling, and Tissue Engineering

Medicine Bulletin, EarlyView.
ABSTRACT Organoid technology has revolutionized biomedical research, disease modeling, drug discovery, and regenerative medicine by providing three‐dimensional (3D) organ‐like structures that closely mimic native human tissues. Derived from pluripotent and adult stem cells, organoids replicate the structural, cellular, and functional characteristics of
Siyuan Song, Zheng Liu, Yi Wang, Bo Gong
wiley   +1 more source

The combine effects of proglumide and fluorouracil on the growth of murine Colon 38 cancer cells in vitro [PDF]

, 2006
Rola gastryny i jej receptorów w rozwoju raka jelita grubego jest od dawna postulowana, lecz nadal pozostaje nie w pełni wyjaśniona. Z kolei skuteczność terapeutyczna fluorouracylu (FU), leku z wyboru w zaawansowanych postaciach raka jelita grubego, jest
Mełeń-Mucha, Gabriela, Mucha, Sławomir, Ławnicka, Hanna   +2 more
core   +1 more source

Radiolabeled Nanogels: From Multimodality Imaging to Combination Therapy of Cancer

Small Science, EarlyView.
Nanogel refers to nanosized particles formed by physical or chemical crosslinking of polymers. Rational design and refinement of nanogel properties are imperative to unlock their full potential, ensuring tailored solutions for personalized cancer management. This review elucidates the transformative potential of radiolabeled nanogels in revolutionizing
Sanchita Ghosh, Weibo Cai, Rubel Chakravarty   +2 more
wiley   +1 more source

GAST (gastrin) [PDF]

, 2011
Review on GAST (gastrin), with data on DNA, on the protein encoded, and where the gene is ...
Chao, C, Hellmich, MR
core   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

Type 2 and type 3 gastric neuroendocrine tumors have high risk of lymph node metastasis: Systematic review and meta‐analysis

Digestive Endoscopy, EarlyView.
Objectives Lymph node metastasis (LNM) is crucial in determining treatment strategies for gastric neuroendocrine tumors (gNETs). While type 3 is considered more aggressive than types 1 and 2 within the clinical subtype of gNETs, the supporting data were insufficient, due to their rarity. We aimed to study the prevalence and risk factors associated with
Yohei Ogata, Waku Hatta, Takeshi Kanno, Masahiro Saito, Xiaoyi Jin, Naoki Asano, Tomoyuki Koike, Akira Imatani, Yuhong Yuan, Atsushi Masamune   +9 more
wiley   +1 more source

The evolving role of positron emission tomography in precision prostate cancer biopsy

European Journal of Clinical Investigation, EarlyView.
Prostate biopsy plays a pivotal role in the detection and characterization of prostate cancer. PSMA PET‐targeted biopsy represents a significant advancement in prostate cancer diagnostics, offering higher sensitivity, specificity and accuracy in detecting clinically significant lesions compared to traditional methods. PSMA PET, when combined with mpMRI,
Alessio Imperiale, Valentina Berti, Roberto Luigi Cazzato, Darejan Mamulashvili Bessac, Alice Ressault, Luca Vaggelli, Mehdi Helali, Camilo Garcia, Hervé Lang, Desirée Deandreis, Luc Mertz, Afshin Gangi   +11 more
wiley   +1 more source

Should the use of omeprazole be allowed during equestrian competition?

Equine Veterinary Journal, Volume 57, Issue 3, Page 555-562, May 2025.
Abstract Background Prioritising equine welfare, making evidenced‐based policy, and consistent decision‐making across sports are crucial to maintaining the social licence for equestrian sport. Regulations on the use of omeprazole during competition differ; all regulators argue that their rules prioritise welfare. This discrepancy is a matter of concern
Madeleine L. H. Campbell, Benjamin W. Sykes   +1 more
wiley   +1 more source

Studies with cholecystokinin. II. Cholecystokinetic potency of porcine gastrins I and II and related peptides in three systems.

Endocrinology, 1969
A sulfated tyrosine residue seems to be an essential structural feature of a number of peptides possessing cholecystokinetic activity. The unsulfated forms of porcine gastrin and cerulein, a decapeptide isolated from frog skin, possessed weaker ...
M. Amer
semanticscholar   +1 more source

The impact of re‐characterizing metastatic pancreatic neuroendocrine tumors: A prospective study

Journal of Neuroendocrinology, EarlyView.
Abstract The biology of metastatic pancreatic neuroendocrine tumors (panNET) may alter over time. It remains to be defined if, how, and when this patient group should be recommended to re‐evaluate the characteristics of their disease. This prospective single‐center, longitudinal cohort study at Uppsala University Hospital, Sweden (NCT03130205 ...
Kazhan Mollazadegan, Johan Botling, Britt Skogseid, Barbro Eriksson, Lovisa Falkman, Liang Zhang, Ieva Lase, Staffan Welin, Anders Sundin, Joakim Crona   +9 more
wiley   +1 more source