Results 41 to 50 of about 580,716 (298)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Methodology for the determination of polyphenol bioaccessibility

Croatian Journal of Food Science and Technology, 2020
Polyphenols are secondary metabolites of plants, commonly present in the human diet. Since they exhibit a wide range of bioactivities, polyphenols are extensively studied in the fields of nutrition and human health.
JOZO IŠTUK, DRAGO ŠUBARIĆ, LIDIJA JAKOBEK   +2 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

In vitro gastrointestinal digestion of meat and fish with alcoholic beverages : oxidation and fatty acid ethyl ester formation

, 2022
Oxidative reactions during cooking and gastrointestinal digestion of meat and fish lead to the formation of various lipid-and protein oxidation products, some of which are toxic.
Vossen, ElsLA220020012653018020001242170000-0002-7212-3566F8AE6B8A-F0ED-11E1-A9DE-61C894A0A6B4, Van Pee, JasperLA220001809246028020039152970000-0002-6972-3552838A2A34-B157-11E8-8280-DC3D5707D3EF, Van Hecke, ThomasLA220020043380768020011910150000-0002-6176-652318091142-F0EE-11E1-A9DE-61C894A0A6B4, De Smet, StefaanLA228010009224660000-0003-1422-805XF4BDC958-F0ED-11E1-A9DE-61C894A0A6B4   +3 more
core  

Effect of Cooking Temperature on Protein Oxidation and in Vitro Digestive Properties of Yak Meat [PDF]

Shipin Kexue
The digestibility of myofibrillar proteins (MP) extracted from yak meat cooked to different internal temperatures of (40, 50, 60, 70 and 80 ℃) was determined during in vitro gastrointestinal digestion, and total carbonyl content, total sulfhydryl content
ZHANG Yan, LI Shengsheng, ZHAO Lizhu, ZHANG Qianglong
doaj   +1 more source

Sweeteners from Different Lingonberry Jams Influence on Bioaccessibility of Vitamin C, Anthocyanins and Antioxidant Capacity under In Vitro Gastrointestinal Digestion

Antioxidants, 2022
Lingonberries are considered anot fully exploited major source of antioxidants. Their health benefits are closely linked to their bioavailability. Due to growing health concerns, consumers are looking for jams prepared with sweeteners other than white ...
Teodora Scrob, Anamaria Hosu, Claudia Cimpoiu   +2 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Improvement of the digestion of cattle slurry via the process of co-digestion

, 2011
The use of maize (Zea mays) as a co-substrate with cattle slurry for the production of biogas was investigated in detail by running several long term digestion trials under different operational conditions in laboratory scale semi-continuous digesters ...
Cornell, Marie
core   +1 more source

Evaluation of bioaccessibility of bioactive compounds in ready-to-eat refrigerated and frozen broccoli using in vitro digestion models

Scientific Reports
Refrigerated and frozen ready-to-eat cooked vegetables are becoming increasingly popular with consumers and catering services. Simulating digestion is essential for accurately assessing the nutritional value of ready-to-eat vegetables, as raw composition
Mohamed Awad Abd Allah, Ghada Khiralla, Hesham Elhariry   +2 more
doaj   +1 more source

Effects of in vitro digestion and fecal fermentation on physico-chemical properties and metabolic behavior of polysaccharides from Clitocybe squamulosa

Food Chemistry: X, 2023
The aim of this study was to establish a human digestion model in vitro to explore the degradation characteristics of a novel high-purity polysaccharide from Clitocybe squamulosa (CSFP2).
Xueran Geng, Dongdong Guo, Tergun Bau, Jiayu Lei, Lijing Xu, Yanfen Cheng, Cuiping Feng, Junlong Meng, Mingchang Chang   +8 more
doaj   +1 more source