Results 41 to 50 of about 1,620,741 (300)

Mutations in ALK and TSC1 in a gastrointestinal stromal tumor: a case report

BMC Surgery, 2021
Background Gastrointestinal stromal tumors rarely occur in children, but when they do, their biological behavior and histopathological patterns differ from those of adults.
Qingzhi Song, Guan Li, Zhuofei Li, Sheng Ao, Jianing Hou, Guoqing Lv   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A duodenal gastrointestinal stromal tumor mimicking a pancreatic neuroendocrine tumor: a case report

Journal of Medical Case Reports, 2022
Background Duodenal gastrointestinal stromal tumors are rare. If tumor growth is extraluminal and involves the head of the pancreas, the diagnosis of a duodenal gastrointestinal stromal tumor is difficult.
Masashi Inoue, Ichiro Ohmori, Atsuhiro Watanabe, Ryujiro Kajikawa, Ryotaro Kajiwara, Hiroyuki Sawada, Kazuaki Miyamoto, Masahiro Ikeda, Kazuhiro Toyota, Seiji Sadamoto, Tadateru Takahashi   +10 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Anagrelide for Gastrointestinal Stromal Tumor [PDF]

Clinical Cancer Research, 2019
Abstract Purpose: Gastrointestinal stromal tumor (GIST) is a common type of soft-tissue sarcoma. Imatinib, an inhibitor of KIT, platelet-derived growth factor receptor alpha (PDGFRA), and a few other tyrosine kinases, is highly effective for GIST, but advanced GISTs frequently progress on ...
Cervera Alejandra, Murumägi Astrid, Kulesskiy Evgeny, Sihto Harri, Joensuu Heikki, Mpindi John-Patrick, Icay Katherine, Wennerberg Krister, Varjosalo Markku, Kallioniemi Olli, Tynninen Olli, Pulkka Olli-Pekka, Laakkonen Pirjo, Lehtonen Rainer, Keskitalo Salla, Hautaniemi Sampsa, Cervera Alejandra, Murumägi Astrid, Kulesskiy Evgeny, Sihto Harri, Joensuu Heikki, Mpindi John-Patrick, Icay Katherine, Wennerberg Krister, Varjosalo Markku, Kallioniemi Olli, Tynninen Olli, Pulkka Olli-Pekka, Laakkonen Pirjo, Lehtonen Rainer, Keskitalo Salla, Hautaniemi Sampsa   +31 more
openaire   +3 more sources

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Orai1 mediates tumor-promoting store-operated Ca entry in human gastrointestinal stromal tumors via c-KIT and the extracellular signal–regulated kinase pathway

Tumor Biology, 2017
Gastrointestinal stromal tumors originate from interstitial cells of Cajal, the pacemaker cells of the gut. Ca 2+ regulates the pacemaker activity of interstitial cells of Cajal.
Lei Wang, Jiaqi Hao, Yijian Zhang, Ziyi Yang, Yang Cao, Wei Lu, Yijun Shu, Lin Jiang, Yunping Hu, Wenjie Lv, Yingbin Liu, Ping Dong   +11 more
doaj   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Laparoscopic resection for large gastric gastrointestinal stromal tumor (GIST): intermediate follow-up results

, 2017
Laparoscopic wedge resection has become a widely accepted treatment for small gastrointestinal stromal tumor (GIST) of the stomach. However, its feasibility as treatment for large gastric GIST is not known.
林明燦;楊卿堯;賴逸儒;陳炯年, Hsiao, Chih-Yang;Yang, Ching-Yao;Lai, I-Rue;Chen, Chiung-Nien;Lin, Ming-Tsan   +1 more
core   +1 more source

Gastric gastrointestinal stromal tumor with osseous differentiation and stromal calcification: A case report and review of literature

SAGE Open Medical Case Reports, 2017
Gastrointestinal stromal tumors are the most common primary mesenchymal tumors of the gastrointestinal tract accounting for 0.1%–3.0% of all gastrointestinal malignancies.
Haneen Al-Maghrabi MD, Abdelrazak Meliti MD   +1 more
doaj   +1 more source