Results 61 to 70 of about 106,101 (300)

Gastric gastrointestinal stromal tumor with osseous differentiation and stromal calcification: A case report and review of literature

SAGE Open Medical Case Reports, 2017
Gastrointestinal stromal tumors are the most common primary mesenchymal tumors of the gastrointestinal tract accounting for 0.1%–3.0% of all gastrointestinal malignancies.
Haneen Al-Maghrabi MD, Abdelrazak Meliti MD   +1 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Orai1 mediates tumor-promoting store-operated Ca entry in human gastrointestinal stromal tumors via c-KIT and the extracellular signal–regulated kinase pathway

Tumor Biology, 2017
Gastrointestinal stromal tumors originate from interstitial cells of Cajal, the pacemaker cells of the gut. Ca 2+ regulates the pacemaker activity of interstitial cells of Cajal.
Lei Wang, Jiaqi Hao, Yijian Zhang, Ziyi Yang, Yang Cao, Wei Lu, Yijun Shu, Lin Jiang, Yunping Hu, Wenjie Lv, Yingbin Liu, Ping Dong   +11 more
doaj   +1 more source

Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma. [PDF]

, 2017
Intratumoral heterogeneity (ITH) is a prominent feature of kidney cancer. It is not known whether it has utility in finding associations between protein expression and clinical parameters. We used ITH that is detected by immunohistochemistry (IHC) to aid
Devarajan, Karthik, Dulaimi, Essel, Jiang, Wei, O\u27Neill, Raymond, Parsons, Theodore, Peiper, Stephen C., Solomides, Charalambos C., Testa, Joseph R., Uzzo, Robert, Wang, Qiong, Yang, Haifeng   +10 more
core   +3 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells [PDF]

, 2016
Indexación: Web of ScienceTumor angiogenesis is widely recognized as one of the hallmarks of cancer. Consequently, during the last decades the development and testing of commercial angiogenic inhibitors has been a central focus for both basic and ...
Carrasco-Avino, G, Corvalan, AH, Owen, GI, Pinto, MP, Sotomayor, P   +4 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Extra-Gastrointestinal Stromal Tumor of Prostate

Balkan Medical Journal, 2017
Background: Extra-gastrointestinal stromal tumor is defined as a mesenchymal neoplasm arising from soft tissues outside the gastrointestinal tract. Prostatic extra-gastrointestinal stromal tumor has rarely been noted.
Demet Etit, Haldun Kar, Neşe Ekinci, Ahmet Emre Yenipazar, Fulya Çakalağaoğlu   +4 more
doaj   +1 more source

Retreatment with anti-EGFR based therapies in metastatic colorectal cancer: impact of intervening time interval and prior anti-EGFR response. [PDF]

, 2015
BackgroundThis retrospective study aims to investigate the activity of retreatment with anti-EGFR-based therapies in order to explore the concept of clonal evolution by evaluating the impact of prior activity and intervening time interval.MethodsEighty ...
Eng, C, Falchook, GS, Fu, S, Garrett, C, George, GC, Hess, K, Hong, DS, Janku, F, Karp, D, Kopetz, S, Kurzrock, R, Liu, X, Meric-Bernstam, F, Naing, A, Overman, MJ, Piha-Paul, SA, Raghav, K, Subbiah, V, Tsimberidou, AM, Wheler, JJ, Zinner, R   +20 more
core   +2 more sources