Results 51 to 60 of about 1,620,741 (300)

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source

Synchronous Primary Adenocarcinoma and Gastrointestinal Stromal Tumor in the Stomach

, 2014
Gastrointestinal stromal tümörler (GİST) ve adenokanserler farklı hücre tiplerinden köken alan birbirinden farklı neoplasm tipleridir. Midede GİST ve adenokanser birlikteliği oldukça nadirdir ve literatürde sadece olgu sunumları şeklindedir. Olgumuzda 76
Bilge Can, Gökhan Selçuk Özbalcı, Bülent Koca, Koray Topgül, Tuğrul Kesicioğlu, İlhan Karabıçak, Hamza Çınar   +6 more
core   +1 more source

Role of human tissue kallikrein in gastrointestinal stromal tumour invasion [PDF]

, 2010
Background: Human tissue kallikrein (hK1) generates vasodilator kinins from kininogen and promotes angiogenesis by kinin-dependent and kinin-independent mechanisms.
Sharman, JA, Mangialardi, GMVU, Sharman, J.A., J A Sharman, Pignatelli, M., Campagnolo, P., H. Zadeh M, P Dominek, Spinetti G, Kränkel, N, Madeddu, P, Kränkel N, H-Zadeh, M., Emanueli, C., M Pignatelli, Spinetti, G., M Chilosi, H-Zadeh, M, A Caporali, Campagnolo P, Dominek, P., Pignatelli M, P Madeddu, Mangialardi G, M H-Zadeh, Emanueli C, N Kränkel, Caporali, A, Pignatelli, M, Spinetti, G, Madeddu, P., Chilosi, M., Mangialardi, G, Emanueli, C, Dominek, PK, Kraenkel, N, Sharman, J A, G Mangialardi, Caporali A, Dominek P, Sharman JA, Madeddu, PR, Mangialardi, G., CHILOSI, Marco, P Campagnolo, Chilosi, M, G Spinetti, Campagnolo, P, Madeddu P., Kränkel, N., C Emanueli, Caporali, A., Caporali, A; id_orcid, Dominek, P   +53 more
core   +1 more source

Gastrointestinal stromal tumors

Saudi Medical Journal, 2019
To evaluate the clinical presentations and immunohistochemical (IHC) properties of gastrointestinal stromal tumors (GISTs) and to compare them to internationally published data.Thirty-six patients diagnosed with GISTs between January 1997 and December 2015 were retrospectively studied in 2 tertiary hospitals.
Alghamdi, Hanan M., Amr, Samir S., Shawarby, Mohamed A., Sheikh, Salwa S., Alsayyah, Ahmed A., Alamri, Ali M., Ismail, Mona H., Almarhabi, Ahmed, Alrefaee, Munir A., Ahmed, Muhammad I.   +9 more
openaire   +2 more sources

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

Advanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang   +6 more
wiley   +1 more source

DeepLNM: A Multimodal Model for Predicting Lymph Node Metastasis in Colorectal Cancer

Advanced Science, EarlyView.
Traditional diagnosis may miss positive LNM cases, and pathologists face a workload; therefore, we develop DeepLNM, a multimodal model that predicts lymph node metastasis in colorectal cancer from H&E WSIs, CT images, and text. DeepLNM is robust across internal, external, and prospective cohorts and, in a user study, improves diagnostic accuracy while ...
Zhengyu Zhang, Chengyu Lu, Zhen Wang, Zhijian Cen, Yangshu Zhou, Danyi Li, Qi Xie, Bingbing Li, Shujing Guo, Zhijun Gan, Er‐ran Zhu, Jinbang Li, Aihetaimu Aimaier, Rui Mao, Weihao Qiu, Chenglong Zhao, Ying Tan, Xiaolin Liu, Huiting Ma, Tiansu Geng, Peiyue Wu, Huijun Du, Yu Wang, Yueping Liu, Li Liang   +24 more
wiley   +1 more source

Ghrelin and gastrointestinal stromal tumors

World Journal of Gastroenterology, 2017
Ghrelin, as a kind of multifunctional protein polypeptide, is mainly produced in the fundus of the stomach and can promote occurrence and development of many tumors, including gastrointestinal tumors, which has been proved by the relevant researches.
Zhu, Chang-Zhen, Liu, Dong, Kang, Wei-Ming, Yu, Jian-Chun, Ma, Zhi-Qiang, Ye, Xin, Li, Kang   +6 more
openaire   +2 more sources

Rectal Gastrointestinal Stromal Tumors

Cureus, 2023
Rectal gastrointestinal stromal tumors (GISTs) are rare types of tumors, but the incidence is increasing, and we now know more about the pathogenesis and management of rectal GIST. The main goal is to resect the tumor with negative microscopic margins. With the development of neoadjuvant Imatinib therapy, preoperative reduction in tumor size has become
Dawara, Shahed A, Naureen, Sameera, Keloth, Tasnim R   +2 more
openaire   +2 more sources

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

Surgical Treatment of Gastric Gastrointestinal Stromal Tumors: Analysis of 92 Operated Patients

, 2011
Aim: To review and evaluate the clinicopathological factors predictive of recurrence after surgical resection for gastrointestinal stromal tumor ( GIST) of the stomach.
LAI, I-RUE;CHEN, CHIUNG-NIEN;LIN, MING-TSAN;LEE, PO-HUANG, 賴逸儒;陳炯年;林明燦;李伯皇   +1 more
core   +1 more source