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Gastrointestinal Stromal Tumors and Neuroendocrine Tumors
Seminars in Oncology Nursing, 2009Patients with rare gastrointestinal (GI) malignancies can exhibit unique objective and subjective manifestations. This article is a primer for the fundamental understanding of some of these diseases, namely gastrointestinal stromal tumors (GIST) and gastroenteropancreatic neuroendocrine tumors (NET) and therapeutic strategies.Epidemiologic data ...
Carolyn, Grande, Daniel G, Haller
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GASTROINTESTINAL STROMAL TUMOR
2010Gastrointestinal stromal tumor, i.e., GIST is by far the most common mesenchymal tumor of the gastrointestinal tract. GIST has received special clinical attention, because it is one of the first solid tumors treated with tyrosine kinase inhibitors as targeted oncological therapy.
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Gastrointestinal stromal tumor (GIST)
Current Treatment Options in Gastroenterology, 2006Gastrointestinal stromal tumors (GISTs), the most common nonepithelial neoplasms of the gastrointestinal (GI) tract, occur most commonly in the stomach. These neoplasms were previously classified as smooth muscle tumors, but it has become apparent that they represent distinct clinicopathologic entities.
Mitchell L, Schubert, Robert, Moghimi
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Gastrointestinal stromal tumor of the prostate
Urology, 2005We present a unique case of an atypical prostate tumor in a 49-year-old man with acute urinary retention. Digital rectal examination revealed a large prostate with a parenchymal mass on the left side. Radiologic imaging showed a 14.2 x 9.6 x 14.0-cm prostatic mass and multiple liver metastases.
Frank, Van der Aa +7 more
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Management of Gastrointestinal Stromal Tumors
Surgical Clinics of North America, 2008A gastrointestinal stromal tumor (GIST) is a rare mesenchymal malignancy of the gastrointestinal (GI) tract. Malignant GISTs were first defined as a separate entity from a collection of nonepithelial malignancies of the GI tract in the 1980s and 1990s based on pathologic and clinical behavior. The discovery of activating KIT mutations as a near-uniform
Matthew T, Hueman, Richard D, Schulick
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Pediatric Gastrointestinal Stromal Tumors
Hematology/Oncology Clinics of North America, 2009Gastrointestinal stromal tumors (GISTs) rarely occur in pediatric patients, but increased recognition of adult GIST has led to better awareness of the existence of this entity in the pediatric population. GIST occurring in pediatric patients has a unique biology and clinical behavior and warrants discussion as an independent entity.
Alberto S, Pappo, Katherine A, Janeway
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Management of Gastrointestinal Stromal Tumors
Surgical Clinics of North America, 2017Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal tract. The stomach is the most common site of origin. Management of GISTs changed after the introduction of molecularly targeted therapies. Although the only potentially curative treatment of resectable primary GISTs is surgery, recurrence is common.
Emily Z, Keung, Chandrajit P, Raut
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Management of Gastrointestinal Stromal Tumors
Surgical Clinics of North America, 2016Gastrointestinal stromal tumors had the reputation for poor outcomes because of their lack of response to nonsurgical interventions. The discovery of gain-of-function mutations involving receptor tyrosine kinase growth factor receptors altered the biological understanding and management.
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Gastrointestinal stromal tumors and leiomyosarcomas
Journal of Surgical Oncology, 2008AbstractOnly recently has gastrointestinal stromal tumor (GIST) been recognized as the most frequent GI mesenchymal neoplasm. Prior to the use of KIT staining, most GI stromal tumors were identified as leiomyosarcoma (LMS). For primary GIST, surgery remains the principal treatment and adjuvant imatinib may improve outcomes.
Steven C, Katz, Ronald P, DeMatteo
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Pediatric Gastrointestinal Stromal Tumor
Journal of Pediatric Gastroenterology and Nutrition, 2023Łukasz Dembiński +3 more
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