Results 201 to 210 of about 54,955 (220)

Liver Cirrhosis Caused by Food-Borne Zoonotic Fasciola gigantica in Cattle in Bangladesh: Pathology and Immunological Orchestra. [PDF]

open access: yesImmun Inflamm Dis
Ali MH   +11 more
europepmc   +1 more source

Breast Cancer Metastases to Atypical Locations: Clinical Insights From Four Cases. [PDF]

open access: yesCureus
Fazaldad NM   +4 more
europepmc   +1 more source
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GATA-3 controls self-renewal in stressed HSCs

Nature Immunology, 2013
The transcription factor GATA-3 is expressed in quiescent hematopoietic stem cells (HSCs) with long-term repopulating ability. Stress-mediated activation of HSCs promotes localization of GATA-3 to the nucleus in a manner dependent on the mitogen-activated protein kinase p38α and restricts self-renewal.
Toshimi, Yoshida, Katia, Georgopoulos
openaire   +2 more sources

Differential expression of GATA-3 in urothelial carcinoma variants

Human Pathology, 2014
GATA binding protein 3 (GATA-3) is a novel immunohistochemical marker for urothelial carcinoma (UC); however, few studies have investigated GATA-3's role as a marker for UC variants. We used immunohistochemistry to assess GATA-3 expression in different UC variants, including micropapillary (n = 46), sarcomatoid (n = 43), small cell carcinoma (n = 22 ...
Yu, Liang   +5 more
openaire   +2 more sources

Role of GATA-3 in Allergic Diseases

Current Molecular Medicine, 2008
GATA-3 is a transcription factor that is specifically expressed in T helper 2 (Th2) cells and plays a critical role in the differentiation of Th2 cells from uncommitted CD4+ lymphocytes. In addition GATA-3 is essential for the gene expression of the cytokines IL-4, IL-5 and IL-13 that mediate allergic inflammation.
openaire   +2 more sources

Defective GATA-3 expression in Th2 LCR-deficient mice

Biochemical and Biophysical Research Communications, 2011
Th2 cell differentiation is critically influenced by transcription factor GATA-3 and by various cis-acting elements including enhancers, silencers and a locus control region (LCR) in the Th2 cytokine locus. Th2 LCR-deficient Th2 cells completely lost the expression of GATA-3 and the phosphorylation of STAT6.
Soo Seok, Hwang   +2 more
openaire   +2 more sources

Linking GATA-3 and interleukin-13: implications in asthma

Inflammation Research, 2013
Asthma is one of the serious global health problems and cause of huge mortality and morbidity. It is characterized by persistent airway inflammation, airway hyperresponsiveness, increased IgE levels and mucus hypersecretion. Asthma is mediated by dominant Th2 immune response, causing enhanced expression of Th2 cytokines. These cytokines are responsible
Sheikh, Rayees   +3 more
openaire   +2 more sources

Regulation of Aquaporin-2 Gene Transcription by GATA-3

Biochemical and Biophysical Research Communications, 1997
To evaluate the functional role of GATA motifs in the 5'-flanking region of a kidney-specific AQP-2 water channel gene, we sought to isolate a GATA factor(s) expressed in collecting ducts and determined the role on the AQP-2 promoter. Two cDNAs encoding GATA factors were isolated from rat kidney, whose sequences were highly homologous with human GATA-2
S, Uchida   +4 more
openaire   +2 more sources

Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites

Development, 2000
ABSTRACT It is now widely accepted that hemopoietic cells born intraembryonically are the best candidates for the seeding of definitive hemopoietic organs. To further understand the mechanisms involved in the generation of definitive hemopoietic stem cells, we analysed the expression of the hemopoietic-related transcription factors Lmo2 ...
A, Manaia   +6 more
openaire   +2 more sources

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