Results 201 to 210 of about 18,250,723 (243)

GATA-3 controls self-renewal in stressed HSCs

Nature Immunology, 2013
The transcription factor GATA-3 is expressed in quiescent hematopoietic stem cells (HSCs) with long-term repopulating ability. Stress-mediated activation of HSCs promotes localization of GATA-3 to the nucleus in a manner dependent on the mitogen-activated protein kinase p38α and restricts self-renewal.
Toshimi, Yoshida, Katia, Georgopoulos
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The Function Role of GATA-3 in Th1 and Th2 Differentiation

Immunologic Research, 2003
GATA-3 plays a central role in regulating Th1 and Th2 cell differentiation. Upon interleukin (IL)-4 binding to its receptor, GATA-3 is induced through the action of Stat6. GATA-3 regulates Th2 cytokine expression not only at the transcription level, such as directly binding to the promoters of the IL-5 and IL-13 gene, but also by the involvement in the
Meixia, Zhou, Wenjun, Ouyang
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Linking GATA-3 and interleukin-13: implications in asthma

Inflammation Research, 2013
Asthma is one of the serious global health problems and cause of huge mortality and morbidity. It is characterized by persistent airway inflammation, airway hyperresponsiveness, increased IgE levels and mucus hypersecretion. Asthma is mediated by dominant Th2 immune response, causing enhanced expression of Th2 cytokines. These cytokines are responsible
Sheikh, Rayees, Fayaz, Malik, Syed Imran, Bukhari, Gurdarshan, Singh   +3 more
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GATA-3 as a Marker of Hormone Response in Breast Cancer

Journal of Surgical Research, 2009
GATA-3 is a transcription factor that orchestrates gene expression profiles during embryogenesis of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 has recently been identified as a key player of luminal cell differentiation in the mammary gland ...
Sandy H, Fang, Yizhen, Chen, Ronald J, Weigel   +2 more
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Regulation of Aquaporin-2 Gene Transcription by GATA-3

Biochemical and Biophysical Research Communications, 1997
To evaluate the functional role of GATA motifs in the 5'-flanking region of a kidney-specific AQP-2 water channel gene, we sought to isolate a GATA factor(s) expressed in collecting ducts and determined the role on the AQP-2 promoter. Two cDNAs encoding GATA factors were isolated from rat kidney, whose sequences were highly homologous with human GATA-2
S, Uchida, Y, Matsumura, T, Rai, S, Sasaki, F, Marumo   +4 more
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Stilbenoids from Vitis amurensis Bind to the GATA-3 DNA-Binding Domain and Inhibit the Transcription by GATA-3

Journal of Natural Products
GATA-3 serves as a key transcription factor driving Th2 cell differentiation and allergic cytokine production. Identifying the natural modulators of GATA-3 could provide therapeutic opportunities for the regulation of allergic responses. This study aimed to identify Vitis amurensis-derived natural products with strong GATA-3 inhibition and to elucidate
Habin Yu, Abdul Bari Shah, Hyunjin Moon, Minhee Kang, Hyeonjun Lee, Hyunsoo Kim, Kyeong Seon Lee, Youngjoo Byun, Yong Woo Jung, Ki Yong Lee, Young Ho Jeon   +10 more
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T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3

Journal of Immunological Methods, 2003
The differentiation of naive T-helper (Th) cells towards Th1 or Th2 cells is regulated by the transcription factors T-box expressed in T-cells (T-bet) and GATA-binding protein-3 (GATA-3). In the present study, the gene expression of T-bet and GATA-3 was measured by semi-quantitive reverse transcription polymerase chain reaction (RT-PCR) in Th1 and Th2 ...
Habiba, Chakir, Haiping, Wang, David E, Lefebvre, John, Webb, Fraser W, Scott   +4 more
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Usefulness of GATA-3 as a marker of seminal epithelium in prostate biopsies

Actas Urológicas Españolas (English Edition), 2017
The incidental presence of seminal vesicle epithelium in prostate needle biopsies is generally recognisable through routine microscopy. However, the biopsy can sometimes be erroneously interpreted as malignant due to its architectural and cytological characteristics, and immunohistochemistry can be useful for correctly identifying the biopsy.
J A, Ortiz-Rey, D, Chantada-de la Fuente, M Á, Peteiro-Cancelo, C, Gómez-de María, M P, San Miguel-Fraile   +4 more
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Expression of GATA-3 in epidermis and hair follicle: Relationship to p63

Biochemical and Biophysical Research Communications, 2007
The epidermis is a multi-layered stratified epithelium continuously renewed by differentiating keratinocytes that develops by the action of p63, a member of the p53 family. The TP63 contains two promoters, resulting in the expression of different proteins, containing (TAp63) or not (DeltaNp63) an amino-terminal transactivation domain, which ...
Chikh A., Sayan E., Thibaut S., Lena A. M., Di Giorgi S., Bernard B. A., MELINO, GENNARO, CANDI, ELEONORA   +7 more
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Overexpression of GATA-3 Protects against the Development of Hypersensitivity Pneumonitis

American Journal of Respiratory and Critical Care Medicine, 2007
Abstract Rationale Hypersensitivity pneumonitis (HP) is mediated by a Th1 immune response. Transcription factor GATA binding protein-3 (GATA-3) is believed to be a key regulator of Th2 differentiation and thus might play regulatory roles in the pathogenesis of hypersensitivity pneumonitis (HP).
Yosuke, Matsuno, Yukio, Ishii, Keigyou, Yoh, Yuko, Morishima, Norihiro, Haraguchi, Norihiro, Kikuchi, Takashi, Iizuka, Takumi, Kiwamoto, Shinsuke, Homma, Akihiro, Nomura, Tohru, Sakamoto, Morio, Ohtsuka, Nobuyuki, Hizawa, Satoru, Takahashi   +13 more
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